Effects of human serun albumin in some biological properties of rhodium(II) complexes
The affinities for human albumin (HSA) of five rhodium(II) complexes of general formula [Rh2(bridge)4] (bridge = acetate, propionate, butyrate, trifluoroacetate and trifluoroacetamidate) were determined by spectrophotometry. In the case of the alkylcarboxylates, an inverse correlation of affinity wi...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Química
2000-01-01
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| Series: | Journal of the Brazilian Chemical Society |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532000000500003 |
| _version_ | 1811234807039918080 |
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| author | Espósito Breno P. Oliveira Elisabeth de Zyngier Szulim B. Najjar Renato |
| author_facet | Espósito Breno P. Oliveira Elisabeth de Zyngier Szulim B. Najjar Renato |
| author_sort | Espósito Breno P. |
| collection | DOAJ |
| description | The affinities for human albumin (HSA) of five rhodium(II) complexes of general formula [Rh2(bridge)4] (bridge = acetate, propionate, butyrate, trifluoroacetate and trifluoroacetamidate) were determined by spectrophotometry. In the case of the alkylcarboxylates, an inverse correlation of affinity with their liposolubilities was observed. Diffusion of the free or protein-bound complexes into Ehrlich cells in vitro seems to be primarily governed by the hydrophobic character of the complex. The complex [Rh2(tfc)4] exhibited affinity towards the protein (K = 214.1) as well as cell partition both in the absence (32.1%) and presence (48.6%) of HSA. The compound HSA: [Rh2(tfc)4] has had its antitumoral action in tumor-bearing Balb-c mice investigated, showing that HSA can be a drug reservoir for the rhodium complex. |
| first_indexed | 2024-04-12T11:42:35Z |
| format | Article |
| id | doaj.art-22fedd7310204a33881d4b0c1334fdea |
| institution | Directory Open Access Journal |
| issn | 0103-5053 |
| language | English |
| last_indexed | 2024-04-12T11:42:35Z |
| publishDate | 2000-01-01 |
| publisher | Sociedade Brasileira de Química |
| record_format | Article |
| series | Journal of the Brazilian Chemical Society |
| spelling | doaj.art-22fedd7310204a33881d4b0c1334fdea2022-12-22T03:34:33ZengSociedade Brasileira de QuímicaJournal of the Brazilian Chemical Society0103-50532000-01-01115447452Effects of human serun albumin in some biological properties of rhodium(II) complexesEspósito Breno P.Oliveira Elisabeth deZyngier Szulim B.Najjar RenatoThe affinities for human albumin (HSA) of five rhodium(II) complexes of general formula [Rh2(bridge)4] (bridge = acetate, propionate, butyrate, trifluoroacetate and trifluoroacetamidate) were determined by spectrophotometry. In the case of the alkylcarboxylates, an inverse correlation of affinity with their liposolubilities was observed. Diffusion of the free or protein-bound complexes into Ehrlich cells in vitro seems to be primarily governed by the hydrophobic character of the complex. The complex [Rh2(tfc)4] exhibited affinity towards the protein (K = 214.1) as well as cell partition both in the absence (32.1%) and presence (48.6%) of HSA. The compound HSA: [Rh2(tfc)4] has had its antitumoral action in tumor-bearing Balb-c mice investigated, showing that HSA can be a drug reservoir for the rhodium complex.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532000000500003rhodiumhuman serum albuminbinding constantantitumor |
| spellingShingle | Espósito Breno P. Oliveira Elisabeth de Zyngier Szulim B. Najjar Renato Effects of human serun albumin in some biological properties of rhodium(II) complexes Journal of the Brazilian Chemical Society rhodium human serum albumin binding constant antitumor |
| title | Effects of human serun albumin in some biological properties of rhodium(II) complexes |
| title_full | Effects of human serun albumin in some biological properties of rhodium(II) complexes |
| title_fullStr | Effects of human serun albumin in some biological properties of rhodium(II) complexes |
| title_full_unstemmed | Effects of human serun albumin in some biological properties of rhodium(II) complexes |
| title_short | Effects of human serun albumin in some biological properties of rhodium(II) complexes |
| title_sort | effects of human serun albumin in some biological properties of rhodium ii complexes |
| topic | rhodium human serum albumin binding constant antitumor |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532000000500003 |
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