Association of MiR-155 Expression with Prognosis in Resected Stage III Non-small Cell Lung Cancer
Background and objective Despite undergoing curative resection, the 5-year survival rate for stage III non-small cell lung cancer (NSCLC) patients is less than 25%. There is a need for biomarkers for prediction of survival and guiding individual therapy. MiR-155 is one of most commonly upregulated m...
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2014-05-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.3779/j.issn.1009-3419.2014.05.10 |
| _version_ | 1818692347395833856 |
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| author | Yi GAO Shengling FU Wenyang JIANG Binfeng LI Yitao TIAN Xiangning FU |
| author_facet | Yi GAO Shengling FU Wenyang JIANG Binfeng LI Yitao TIAN Xiangning FU |
| author_sort | Yi GAO |
| collection | DOAJ |
| description | Background and objective Despite undergoing curative resection, the 5-year survival rate for stage III non-small cell lung cancer (NSCLC) patients is less than 25%. There is a need for biomarkers for prediction of survival and guiding individual therapy. MiR-155 is one of most commonly upregulated miRNAs in malignancies, and regulates multiple pro-oncogenic pathways. We aimed to investigate the prognostic impact of miR-155 in resected stage III NSCLC patients. Methods Tumor formalin-fixed, paraffin-embedded (FFPE) from 162 resected stage III NSCLC patients were collected. Total RNA including miRNA was extracted, and qRT-PCR was used to determine the expression of miR-155. Results Spearman rank correlation test showed a positive correlation between miR-155 expression and nodal status (r=0.169, P=0.032). MiR-155 expression had a significant prognostic impact in the total cohort (P<0.001), in squamous cell carcinomas (P=0.002) and in adenocarcinomas (P=0.003). In N0-1 subgroup, miR-155 expression did not have a significant prognostic on overall survival in univariate analysis (P=0.319). In N2 subgroup, miR-155 had a negative prognostic effect on OS in univariate analysis (P<0.001). Cox regression analysis revealed that miR-155 expression was unfavorable prognostic factors of OS (RR=2.311, 95%CI: 1.479-3.611, P<0.001). Conclusion High expression of miR-155 represents a valuable marker of poor clinical outcomes in patients with stage III NSCLC. |
| first_indexed | 2024-12-17T12:56:21Z |
| format | Article |
| id | doaj.art-22ff3c3a69914ac4a9241307c60b0be6 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 |
| language | zho |
| last_indexed | 2024-12-17T12:56:21Z |
| publishDate | 2014-05-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-22ff3c3a69914ac4a9241307c60b0be62022-12-21T21:47:28ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34192014-05-0117541742310.3779/j.issn.1009-3419.2014.05.10Association of MiR-155 Expression with Prognosis in Resected
Stage III Non-small Cell Lung CancerYi GAO0Shengling FU1Wenyang JIANG2Binfeng LI3Yitao TIAN4Xiangning FU5Department of Thoracic Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Thoracic Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Thoracic Surgery, Renmin Hospital, Wuhan University, Wuhan 430060, ChinaDepartment of Thoracic Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Thoracic Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, ChinaDepartment of Thoracic Surgery, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, ChinaBackground and objective Despite undergoing curative resection, the 5-year survival rate for stage III non-small cell lung cancer (NSCLC) patients is less than 25%. There is a need for biomarkers for prediction of survival and guiding individual therapy. MiR-155 is one of most commonly upregulated miRNAs in malignancies, and regulates multiple pro-oncogenic pathways. We aimed to investigate the prognostic impact of miR-155 in resected stage III NSCLC patients. Methods Tumor formalin-fixed, paraffin-embedded (FFPE) from 162 resected stage III NSCLC patients were collected. Total RNA including miRNA was extracted, and qRT-PCR was used to determine the expression of miR-155. Results Spearman rank correlation test showed a positive correlation between miR-155 expression and nodal status (r=0.169, P=0.032). MiR-155 expression had a significant prognostic impact in the total cohort (P<0.001), in squamous cell carcinomas (P=0.002) and in adenocarcinomas (P=0.003). In N0-1 subgroup, miR-155 expression did not have a significant prognostic on overall survival in univariate analysis (P=0.319). In N2 subgroup, miR-155 had a negative prognostic effect on OS in univariate analysis (P<0.001). Cox regression analysis revealed that miR-155 expression was unfavorable prognostic factors of OS (RR=2.311, 95%CI: 1.479-3.611, P<0.001). Conclusion High expression of miR-155 represents a valuable marker of poor clinical outcomes in patients with stage III NSCLC.http://dx.doi.org/10.3779/j.issn.1009-3419.2014.05.10Lung neoplasmsMiR-155Prognosis |
| spellingShingle | Yi GAO Shengling FU Wenyang JIANG Binfeng LI Yitao TIAN Xiangning FU Association of MiR-155 Expression with Prognosis in Resected Stage III Non-small Cell Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms MiR-155 Prognosis |
| title | Association of MiR-155 Expression with Prognosis in Resected
Stage III Non-small Cell Lung Cancer |
| title_full | Association of MiR-155 Expression with Prognosis in Resected
Stage III Non-small Cell Lung Cancer |
| title_fullStr | Association of MiR-155 Expression with Prognosis in Resected
Stage III Non-small Cell Lung Cancer |
| title_full_unstemmed | Association of MiR-155 Expression with Prognosis in Resected
Stage III Non-small Cell Lung Cancer |
| title_short | Association of MiR-155 Expression with Prognosis in Resected
Stage III Non-small Cell Lung Cancer |
| title_sort | association of mir 155 expression with prognosis in resected
stage iii non small cell lung cancer |
| topic | Lung neoplasms MiR-155 Prognosis |
| url | http://dx.doi.org/10.3779/j.issn.1009-3419.2014.05.10 |
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