Hsp70, in Combination with IL-15 and PD-1 Blocker, Interferes with The Induction of Cytotoxic NK Cells in Relapsed Acute Myeloid Leukemia Patients

Hsp70, in Combination with IL-15 and PD-1 Blocker, Interferes with The Induction of Cytotoxic NK Cells in Relapsed Acute Myeloid Leukemia Patients

Objective: Natural killer (NK) cells are critical immune cells for acute myeloid leukemia (AML) targeting. However,little is known about the relationship between using checkpoint inhibitors and heat shock protein 70 (Hsp70) as NK cellactivators to control AML. Therefore, the study aims to find the b...

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Bibliographic Details
Main Authors: Javad Firouzi, Abbas Hajifathali, Masoumeh Azimi, Neda Parvini, Fatemeh Ghaemi, Niloufar Shayan Asl, Amir Abbas Hedayati Asl, Majid Safa, Marzieh Ebrahimi
Format: Article
Language:English
Published: Royan Institute (ACECR), Tehran 2023-02-01
Series:Cell Journal
Subjects:
acute myeloid leukemia
hsp70
immunotherapy
natural killer cells
pd-1
Online Access:https://www.celljournal.org/article_701725_40707905f9259e7c8f3cfe586f473723.pdf

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