Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case series
Hypoparathyroidism is a rare endocrine disorder characterized by hypocalcemia and hyperphosphatemia, due to absent or inappropriately low serum parathyroid hormone (PTH) levels. The chronic postoperative hypoparathyroidism accounts approximately 75% of patients; the genetic, autoimmune or idiopathic...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Endocrinology Research Centre
2021-07-01
|
| Series: | Ожирение и метаболизм |
| Subjects: | |
| Online Access: | https://www.omet-endojournals.ru/jour/article/view/12729 |
| _version_ | 1797204586094657536 |
|---|---|
| author | E. V. Kovaleva A. K. Eremkina N. G. Mokrysheva |
| author_facet | E. V. Kovaleva A. K. Eremkina N. G. Mokrysheva |
| author_sort | E. V. Kovaleva |
| collection | DOAJ |
| description | Hypoparathyroidism is a rare endocrine disorder characterized by hypocalcemia and hyperphosphatemia, due to absent or inappropriately low serum parathyroid hormone (PTH) levels. The chronic postoperative hypoparathyroidism accounts approximately 75% of patients; the genetic, autoimmune or idiopathic forms are significantly less common. Today, chronic hypoparathyroidism remains the last major endocrine deficiency, for which hormonal replacement therapy has not found widespread use. Achieving the target levels of phosphorus-calcium metabolism is an important factor of the disease control, required for the prevention of short- and long-term complications. The standard therapy with active metabolites/analogues of vitamin D (alfacalcidol, calcitriol) and calcium supplements does not always allow to achieve the target treatment goals. Despite high doses of calcium and active vitamin D, some patients suffer from unstable calcium levels and associated symptoms.The measurement of serum calcium and phosphorus in the early morning hours remains the main laboratory tests for such patients, but in sometimes this diagnostic approach does not really reflect the true picture.The presented clinical cases describe the changes of both hyper- and hypocalcemia within one day in patients with chronic postsurgical hypoparathyroidism managed by standard therapy. |
| first_indexed | 2024-03-08T09:12:57Z |
| format | Article |
| id | doaj.art-2301d939c1344a98982c1e24d3a72ad5 |
| institution | Directory Open Access Journal |
| issn | 2071-8713 2306-5524 |
| language | English |
| last_indexed | 2024-04-24T08:37:35Z |
| publishDate | 2021-07-01 |
| publisher | Endocrinology Research Centre |
| record_format | Article |
| series | Ожирение и метаболизм |
| spelling | doaj.art-2301d939c1344a98982c1e24d3a72ad52024-04-16T16:16:13ZengEndocrinology Research CentreОжирение и метаболизм2071-87132306-55242021-07-0118217517910.14341/omet1272910874Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case seriesE. V. Kovaleva0A. K. Eremkina1N. G. Mokrysheva2Endocrinology Research Centre, Moscow, RussiaEndocrinology Research Centre, Moscow, RussiaEndocrinology Research Centre, Moscow, RussiaHypoparathyroidism is a rare endocrine disorder characterized by hypocalcemia and hyperphosphatemia, due to absent or inappropriately low serum parathyroid hormone (PTH) levels. The chronic postoperative hypoparathyroidism accounts approximately 75% of patients; the genetic, autoimmune or idiopathic forms are significantly less common. Today, chronic hypoparathyroidism remains the last major endocrine deficiency, for which hormonal replacement therapy has not found widespread use. Achieving the target levels of phosphorus-calcium metabolism is an important factor of the disease control, required for the prevention of short- and long-term complications. The standard therapy with active metabolites/analogues of vitamin D (alfacalcidol, calcitriol) and calcium supplements does not always allow to achieve the target treatment goals. Despite high doses of calcium and active vitamin D, some patients suffer from unstable calcium levels and associated symptoms.The measurement of serum calcium and phosphorus in the early morning hours remains the main laboratory tests for such patients, but in sometimes this diagnostic approach does not really reflect the true picture.The presented clinical cases describe the changes of both hyper- and hypocalcemia within one day in patients with chronic postsurgical hypoparathyroidism managed by standard therapy.https://www.omet-endojournals.ru/jour/article/view/12729сalciumhypoparathyroidismdaily profilehypercalcemiaalfacalcidol |
| spellingShingle | E. V. Kovaleva A. K. Eremkina N. G. Mokrysheva Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case series Ожирение и метаболизм сalcium hypoparathyroidism daily profile hypercalcemia alfacalcidol |
| title | Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case series |
| title_full | Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case series |
| title_fullStr | Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case series |
| title_full_unstemmed | Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case series |
| title_short | Daily calcium profile in diagnosis of hypo- and hypercalcemia in patients with chronic hypoparathyroidism. clinical case series |
| title_sort | daily calcium profile in diagnosis of hypo and hypercalcemia in patients with chronic hypoparathyroidism clinical case series |
| topic | сalcium hypoparathyroidism daily profile hypercalcemia alfacalcidol |
| url | https://www.omet-endojournals.ru/jour/article/view/12729 |
| work_keys_str_mv | AT evkovaleva dailycalciumprofileindiagnosisofhypoandhypercalcemiainpatientswithchronichypoparathyroidismclinicalcaseseries AT akeremkina dailycalciumprofileindiagnosisofhypoandhypercalcemiainpatientswithchronichypoparathyroidismclinicalcaseseries AT ngmokrysheva dailycalciumprofileindiagnosisofhypoandhypercalcemiainpatientswithchronichypoparathyroidismclinicalcaseseries |