Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation
Ting Song Lim,1 ShaoRong Liew,1 Xiang Jie Tee,1 Ian Chong,1 Fui Jun Lo,1 Meng Jun Ho,1 KuokTjun Ong,1 Maurizio Cavallini2 1Clique Clinic, Petaling Jaya, Selangor, Malaysia; 2Dermatology and Dermatosurgery Department, CDI Centro Diagnostico Italiano, Milan, ItalyCorrespondence: Ting Song Lim, Clique...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2024-02-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/polynucleotides-hpt-for-asian-skin-regeneration-and-rejuvenation-peer-reviewed-fulltext-article-CCID |
| _version_ | 1827351449474957312 |
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| author | Lim TS Liew S Tee XJ Chong I Lo FJ Ho MJ Ong K Cavallini M |
| author_facet | Lim TS Liew S Tee XJ Chong I Lo FJ Ho MJ Ong K Cavallini M |
| author_sort | Lim TS |
| collection | DOAJ |
| description | Ting Song Lim,1 ShaoRong Liew,1 Xiang Jie Tee,1 Ian Chong,1 Fui Jun Lo,1 Meng Jun Ho,1 KuokTjun Ong,1 Maurizio Cavallini2 1Clique Clinic, Petaling Jaya, Selangor, Malaysia; 2Dermatology and Dermatosurgery Department, CDI Centro Diagnostico Italiano, Milan, ItalyCorrespondence: Ting Song Lim, Clique Clinic, 4, Jalan 19/36, Seksyen 19, Petaling Jaya, Selangor, 46300, Malaysia, Email drlim@cliqueclinic.comIntroduction: Even lightly compromised skin may impact self-esteem and social behaviour. After intradermal infiltration, natural-origin Polynucleotides High Purification Technology (PN HPT) promote new collagen and extracellular matrix production, translating into a physiological correction of the ageing skin. The study aimed to explore the benefits of intradermal PN HPT on the four perceptual skin quality categories “Skin Tone Evenness”, “Skin Surface Evenness”, “Skin Firmness”, and “Skin Glow” in a representative sample of 30 Asian subjects (mean age 40.2± 11.4 years old).Methods: Study protocol: three intradermal injections of a PN HPT-based Class III CE-marked medical device at T0 (baseline assessment and first treatment session), T1 (four weeks after baseline), and T2 (eight weeks after baseline), with efficacy and safety evaluations at T1, T2, T3 (four months after baseline) and T4 (six months after baseline). Quantitative and qualitative assessments: 3D skin analysis system QuantifiCare and Global Aesthetic Improvement Scale (GAIS, Investigator and Patient subscales).Results: PN HPT treatment led to a meaningful and statistically significant improvement of the skin surface, firmness, pigmentation, and radiance, with no early- or late-onset adverse events and benefits persisting up to the sixth-month visit in all subjects. At T4, 33% and 43% of treated subjects felt “Much Improved” and “Very Much Improved” (optimal result); 56% and 44% of treated subjects felt “Satisfied” or “Very Satisfied”. At T4, the mean Investigator GAIS scores were 3.33 out of 5.0 for the “Skin Tone Evenness” skin quality perceptual category, 3.46 for the “Skin Surface Evenness” category, 3.61 for “Skin Firmness”, and 3.45 per for the radiance determinant of the “Skin Glow” category.Conclusion: Intradermal treatment with the PN HPT-based medical device led to a meaningful improvement of the skin surface, firmness, pigmentation, and radiance with complete safety. The aesthetic benefits persisted up to the sixth-month visit in all subjects.Keywords: emergent perceptual skin quality categories, EPCs, GAIS, global aesthetic improvement scale, polynucleotides HPT, PN HPT, QuantifiCare, skin quality |
| first_indexed | 2024-03-08T02:04:31Z |
| format | Article |
| id | doaj.art-23037627240241cc8ed824dac4dcfdc0 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-03-08T02:04:31Z |
| publishDate | 2024-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-23037627240241cc8ed824dac4dcfdc02024-02-13T19:43:10ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152024-02-01Volume 1741743190430Polynucleotides HPT for Asian Skin Regeneration and RejuvenationLim TSLiew STee XJChong ILo FJHo MJOng KCavallini MTing Song Lim,1 ShaoRong Liew,1 Xiang Jie Tee,1 Ian Chong,1 Fui Jun Lo,1 Meng Jun Ho,1 KuokTjun Ong,1 Maurizio Cavallini2 1Clique Clinic, Petaling Jaya, Selangor, Malaysia; 2Dermatology and Dermatosurgery Department, CDI Centro Diagnostico Italiano, Milan, ItalyCorrespondence: Ting Song Lim, Clique Clinic, 4, Jalan 19/36, Seksyen 19, Petaling Jaya, Selangor, 46300, Malaysia, Email drlim@cliqueclinic.comIntroduction: Even lightly compromised skin may impact self-esteem and social behaviour. After intradermal infiltration, natural-origin Polynucleotides High Purification Technology (PN HPT) promote new collagen and extracellular matrix production, translating into a physiological correction of the ageing skin. The study aimed to explore the benefits of intradermal PN HPT on the four perceptual skin quality categories “Skin Tone Evenness”, “Skin Surface Evenness”, “Skin Firmness”, and “Skin Glow” in a representative sample of 30 Asian subjects (mean age 40.2± 11.4 years old).Methods: Study protocol: three intradermal injections of a PN HPT-based Class III CE-marked medical device at T0 (baseline assessment and first treatment session), T1 (four weeks after baseline), and T2 (eight weeks after baseline), with efficacy and safety evaluations at T1, T2, T3 (four months after baseline) and T4 (six months after baseline). Quantitative and qualitative assessments: 3D skin analysis system QuantifiCare and Global Aesthetic Improvement Scale (GAIS, Investigator and Patient subscales).Results: PN HPT treatment led to a meaningful and statistically significant improvement of the skin surface, firmness, pigmentation, and radiance, with no early- or late-onset adverse events and benefits persisting up to the sixth-month visit in all subjects. At T4, 33% and 43% of treated subjects felt “Much Improved” and “Very Much Improved” (optimal result); 56% and 44% of treated subjects felt “Satisfied” or “Very Satisfied”. At T4, the mean Investigator GAIS scores were 3.33 out of 5.0 for the “Skin Tone Evenness” skin quality perceptual category, 3.46 for the “Skin Surface Evenness” category, 3.61 for “Skin Firmness”, and 3.45 per for the radiance determinant of the “Skin Glow” category.Conclusion: Intradermal treatment with the PN HPT-based medical device led to a meaningful improvement of the skin surface, firmness, pigmentation, and radiance with complete safety. The aesthetic benefits persisted up to the sixth-month visit in all subjects.Keywords: emergent perceptual skin quality categories, EPCs, GAIS, global aesthetic improvement scale, polynucleotides HPT, PN HPT, QuantifiCare, skin qualityhttps://www.dovepress.com/polynucleotides-hpt-for-asian-skin-regeneration-and-rejuvenation-peer-reviewed-fulltext-article-CCIDemergent perceptual skin quality categoriesepcsgaisglobal aesthetic improvement scalepolynucleotides hptpn hptquantificareskin quality. |
| spellingShingle | Lim TS Liew S Tee XJ Chong I Lo FJ Ho MJ Ong K Cavallini M Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation Clinical, Cosmetic and Investigational Dermatology emergent perceptual skin quality categories epcs gais global aesthetic improvement scale polynucleotides hpt pn hpt quantificare skin quality. |
| title | Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation |
| title_full | Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation |
| title_fullStr | Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation |
| title_full_unstemmed | Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation |
| title_short | Polynucleotides HPT for Asian Skin Regeneration and Rejuvenation |
| title_sort | polynucleotides hpt for asian skin regeneration and rejuvenation |
| topic | emergent perceptual skin quality categories epcs gais global aesthetic improvement scale polynucleotides hpt pn hpt quantificare skin quality. |
| url | https://www.dovepress.com/polynucleotides-hpt-for-asian-skin-regeneration-and-rejuvenation-peer-reviewed-fulltext-article-CCID |
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