Clinical outcomes of radio‐hyperthermo‐chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched‐pair cohort study
Abstract Regional hyperthermia is considered to enhance the antitumor effects of chemotherapy and radiotherapy. In this study, we confirmed the efficacy of concomitant radiotherapy, hyperthermia, and chemotherapy (RHC) for neoadjuvant treatment of malignant soft tissue sarcoma (STS). From 1994 to 20...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-04-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1366 |
| _version_ | 1827153873844830208 |
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| author | Hisaki Aiba Satoshi Yamada Jun Mizutani Norio Yamamoto Hideki Okamoto Katsuhiro Hayashi Hiroaki Kimura Akihiko Takeuchi Shinji Miwa Akira Kawai Kenichi Yoshimura Hiroyuki Tsuchiya Takanobu Otsuka |
| author_facet | Hisaki Aiba Satoshi Yamada Jun Mizutani Norio Yamamoto Hideki Okamoto Katsuhiro Hayashi Hiroaki Kimura Akihiko Takeuchi Shinji Miwa Akira Kawai Kenichi Yoshimura Hiroyuki Tsuchiya Takanobu Otsuka |
| author_sort | Hisaki Aiba |
| collection | DOAJ |
| description | Abstract Regional hyperthermia is considered to enhance the antitumor effects of chemotherapy and radiotherapy. In this study, we confirmed the efficacy of concomitant radiotherapy, hyperthermia, and chemotherapy (RHC) for neoadjuvant treatment of malignant soft tissue sarcoma (STS). From 1994 to 2013, we performed RHC in 150 patients. This study was limited to 60 patients using the following exclusion criteria: salvage for recurrence or unplanned excision, trunk location, metastasis at initiation, non‐STS, and no definitive surgery. As a control group, we collected data from 11,031 patients in the Bone and Soft Tissue Tumor Registry in Japan (BSTT). We performed multivariate logistic regression analysis, and propensity scores were created for comparisons between groups. The primary outcome of this study was to compare oncologic outcomes (5‐year local control rate [LC] and overall survival rate [OS]). In the RHC group, two local recurrences (3.3%) occurred, and no patients underwent amputation. Margins of definitive surgery were not identical between groups [wide margins (60.0% vs. 85.3%), marginal margins (28.3% vs. 10.5%), and intralesional margins (7.4% vs. 4.2%), RHC and BSTT groups, respectively, P < 0.001]. After adjustment, the difference in OS was not significant between groups (HR = 1.26, P = 0.532); however, a statistically significant difference in LC was observed (HR = 4.82, P = 0.037). RHC resulted in a high LC at 5 years compared to the BSTT group, and amputation was averted in the RHC group, despite the wider margins in the BSTT group. This indicates that less invasive surgery might be achieved with effective neoadjuvant therapy. |
| first_indexed | 2025-03-20T22:28:41Z |
| format | Article |
| id | doaj.art-230435ddb1024d11a0ee0bb487b232cd |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2025-03-20T22:28:41Z |
| publishDate | 2018-04-01 |
| publisher | Wiley |
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| series | Cancer Medicine |
| spelling | doaj.art-230435ddb1024d11a0ee0bb487b232cd2024-08-08T05:41:07ZengWileyCancer Medicine2045-76342018-04-01741560157110.1002/cam4.1366Clinical outcomes of radio‐hyperthermo‐chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched‐pair cohort studyHisaki Aiba0Satoshi Yamada1Jun Mizutani2Norio Yamamoto3Hideki Okamoto4Katsuhiro Hayashi5Hiroaki Kimura6Akihiko Takeuchi7Shinji Miwa8Akira Kawai9Kenichi Yoshimura10Hiroyuki Tsuchiya11Takanobu Otsuka12Department of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi JapanDepartment of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi JapanDepartment of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi JapanDepartment of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa JapanDepartment of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi JapanDepartment of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa JapanDepartment of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa JapanDepartment of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa JapanDepartment of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi JapanDepartment of Musculoskeletal Oncology National Cancer Center Hospital Tokyo JapanDepartment of Biostatistics Innovative Clinical Research Center Kanazawa University Kanazawa Ishikawa JapanDepartment of Orthopedic Surgery Graduate School of Medical Sciences Kanazawa University Kanazawa Ishikawa JapanDepartment of Orthopedic Surgery Nagoya City University Graduate School of Medical Sciences Nagoya Aichi JapanAbstract Regional hyperthermia is considered to enhance the antitumor effects of chemotherapy and radiotherapy. In this study, we confirmed the efficacy of concomitant radiotherapy, hyperthermia, and chemotherapy (RHC) for neoadjuvant treatment of malignant soft tissue sarcoma (STS). From 1994 to 2013, we performed RHC in 150 patients. This study was limited to 60 patients using the following exclusion criteria: salvage for recurrence or unplanned excision, trunk location, metastasis at initiation, non‐STS, and no definitive surgery. As a control group, we collected data from 11,031 patients in the Bone and Soft Tissue Tumor Registry in Japan (BSTT). We performed multivariate logistic regression analysis, and propensity scores were created for comparisons between groups. The primary outcome of this study was to compare oncologic outcomes (5‐year local control rate [LC] and overall survival rate [OS]). In the RHC group, two local recurrences (3.3%) occurred, and no patients underwent amputation. Margins of definitive surgery were not identical between groups [wide margins (60.0% vs. 85.3%), marginal margins (28.3% vs. 10.5%), and intralesional margins (7.4% vs. 4.2%), RHC and BSTT groups, respectively, P < 0.001]. After adjustment, the difference in OS was not significant between groups (HR = 1.26, P = 0.532); however, a statistically significant difference in LC was observed (HR = 4.82, P = 0.037). RHC resulted in a high LC at 5 years compared to the BSTT group, and amputation was averted in the RHC group, despite the wider margins in the BSTT group. This indicates that less invasive surgery might be achieved with effective neoadjuvant therapy.https://doi.org/10.1002/cam4.1366hyperthermia sarcomaneoadjuvant chemotherapyradiotherapysoft tissue sarcomasoft tissue sarcoma‐chemotherapy |
| spellingShingle | Hisaki Aiba Satoshi Yamada Jun Mizutani Norio Yamamoto Hideki Okamoto Katsuhiro Hayashi Hiroaki Kimura Akihiko Takeuchi Shinji Miwa Akira Kawai Kenichi Yoshimura Hiroyuki Tsuchiya Takanobu Otsuka Clinical outcomes of radio‐hyperthermo‐chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched‐pair cohort study Cancer Medicine hyperthermia sarcoma neoadjuvant chemotherapy radiotherapy soft tissue sarcoma soft tissue sarcoma‐chemotherapy |
| title | Clinical outcomes of radio‐hyperthermo‐chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched‐pair cohort study |
| title_full | Clinical outcomes of radio‐hyperthermo‐chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched‐pair cohort study |
| title_fullStr | Clinical outcomes of radio‐hyperthermo‐chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched‐pair cohort study |
| title_full_unstemmed | Clinical outcomes of radio‐hyperthermo‐chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched‐pair cohort study |
| title_short | Clinical outcomes of radio‐hyperthermo‐chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in Japan: a retrospective matched‐pair cohort study |
| title_sort | clinical outcomes of radio hyperthermo chemotherapy for soft tissue sarcoma compared to a soft tissue sarcoma registry in japan a retrospective matched pair cohort study |
| topic | hyperthermia sarcoma neoadjuvant chemotherapy radiotherapy soft tissue sarcoma soft tissue sarcoma‐chemotherapy |
| url | https://doi.org/10.1002/cam4.1366 |
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