Effect of high nitrate vegetable juice supplementation on plasma nitrate and blood pressure in adults: a pilot randomized crossover intervention in healthy volunteers
Beetroot juice (BRJ) has been demonstrated to decrease blood pressure (BP) due to the high inorganic nitrate content. This pilot randomized crossover trial aimed to investigate the effect of two different high nitrate vegetable juices on plasma nitrate concentrations and BP in healthy adults. Eighte...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2022-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679022000349/type/journal_article |
| _version_ | 1811155968776470528 |
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| author | Nour A. Elsahoryi Christopher Cardwell Sarah Gilchrist Jayne V. Woodside |
| author_facet | Nour A. Elsahoryi Christopher Cardwell Sarah Gilchrist Jayne V. Woodside |
| author_sort | Nour A. Elsahoryi |
| collection | DOAJ |
| description | Beetroot juice (BRJ) has been demonstrated to decrease blood pressure (BP) due to the high inorganic nitrate content. This pilot randomized crossover trial aimed to investigate the effect of two different high nitrate vegetable juices on plasma nitrate concentrations and BP in healthy adults. Eighteen healthy volunteers were randomized to receive 115 ml of BRJ or 250 ml of green leafy vegetable juice for 7 d which contained similar amounts of nitrate (340 mg) daily. Blood samples were collected, and clinic BP measured at baseline and at the end of each juice consumption. Daily home BP assessment was conducted 2 h after juice consumption. Nitrate and nitrite concentrations were analysed using a commercially available kit on a Triturus automated ELISA analyser. Hills and Armitage analysis was used for the two-period crossover design and paired sample t-tests were performed to compare within-group changes. Plasma nitrate and nitrite concentrations significantly increased and there was a significant reduction in clinic and home systolic blood pressure (SBP) mean during the BRJ period (P-values 0⋅004 and 0⋅002, respectively). Home diastolic blood pressure (DBP) reduced significantly during green leafy vegetable juice consumption week (P-value 0⋅03). The difference between groups did not reach statistical significance during the formal crossover analysis adjusted for period effects. BRJ and green leafy vegetable juice may reduce SBP or DBP, but there was no statistically significant difference between the two juices, although this was only a pilot study. |
| first_indexed | 2024-04-10T04:42:33Z |
| format | Article |
| id | doaj.art-2304f18c223b43958cc6d428c5807d20 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:42:33Z |
| publishDate | 2022-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-2304f18c223b43958cc6d428c5807d202023-03-09T12:38:45ZengCambridge University PressJournal of Nutritional Science2048-67902022-01-011110.1017/jns.2022.34Effect of high nitrate vegetable juice supplementation on plasma nitrate and blood pressure in adults: a pilot randomized crossover intervention in healthy volunteersNour A. Elsahoryi0https://orcid.org/0000-0003-2029-4045Christopher Cardwell1Sarah Gilchrist2Jayne V. Woodside3Centre for Public Health, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UK Department of Nutrition, Faculty of Pharmacy & Medical Sciences, University of Petra, Amman, JordanCentre for Public Health, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UKCentre for Public Health, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UKCentre for Public Health, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UKBeetroot juice (BRJ) has been demonstrated to decrease blood pressure (BP) due to the high inorganic nitrate content. This pilot randomized crossover trial aimed to investigate the effect of two different high nitrate vegetable juices on plasma nitrate concentrations and BP in healthy adults. Eighteen healthy volunteers were randomized to receive 115 ml of BRJ or 250 ml of green leafy vegetable juice for 7 d which contained similar amounts of nitrate (340 mg) daily. Blood samples were collected, and clinic BP measured at baseline and at the end of each juice consumption. Daily home BP assessment was conducted 2 h after juice consumption. Nitrate and nitrite concentrations were analysed using a commercially available kit on a Triturus automated ELISA analyser. Hills and Armitage analysis was used for the two-period crossover design and paired sample t-tests were performed to compare within-group changes. Plasma nitrate and nitrite concentrations significantly increased and there was a significant reduction in clinic and home systolic blood pressure (SBP) mean during the BRJ period (P-values 0⋅004 and 0⋅002, respectively). Home diastolic blood pressure (DBP) reduced significantly during green leafy vegetable juice consumption week (P-value 0⋅03). The difference between groups did not reach statistical significance during the formal crossover analysis adjusted for period effects. BRJ and green leafy vegetable juice may reduce SBP or DBP, but there was no statistically significant difference between the two juices, although this was only a pilot study.https://www.cambridge.org/core/product/identifier/S2048679022000349/type/journal_articleBeetrootHypertensionNitrateVegetable juice |
| spellingShingle | Nour A. Elsahoryi Christopher Cardwell Sarah Gilchrist Jayne V. Woodside Effect of high nitrate vegetable juice supplementation on plasma nitrate and blood pressure in adults: a pilot randomized crossover intervention in healthy volunteers Journal of Nutritional Science Beetroot Hypertension Nitrate Vegetable juice |
| title | Effect of high nitrate vegetable juice supplementation on plasma nitrate and blood pressure in adults: a pilot randomized crossover intervention in healthy volunteers |
| title_full | Effect of high nitrate vegetable juice supplementation on plasma nitrate and blood pressure in adults: a pilot randomized crossover intervention in healthy volunteers |
| title_fullStr | Effect of high nitrate vegetable juice supplementation on plasma nitrate and blood pressure in adults: a pilot randomized crossover intervention in healthy volunteers |
| title_full_unstemmed | Effect of high nitrate vegetable juice supplementation on plasma nitrate and blood pressure in adults: a pilot randomized crossover intervention in healthy volunteers |
| title_short | Effect of high nitrate vegetable juice supplementation on plasma nitrate and blood pressure in adults: a pilot randomized crossover intervention in healthy volunteers |
| title_sort | effect of high nitrate vegetable juice supplementation on plasma nitrate and blood pressure in adults a pilot randomized crossover intervention in healthy volunteers |
| topic | Beetroot Hypertension Nitrate Vegetable juice |
| url | https://www.cambridge.org/core/product/identifier/S2048679022000349/type/journal_article |
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