Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICU
AbstractThe purpose was to investigate how well age-adjusted modified quick Sequential Organ Failure Assessment (qSOFA) scores paired with blood glucose and lactate levels predict the outcomes of septicemic children in the pediatric intensive care unit (PICU). One hundred children who were diagnosed...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2024.2337714 |
| _version_ | 1797216881220780032 |
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| author | Wanyu Jia Xue Zhang Ruiyang Sun Peng Li Daobin Wang Xue Gu Chunlan Song |
| author_facet | Wanyu Jia Xue Zhang Ruiyang Sun Peng Li Daobin Wang Xue Gu Chunlan Song |
| author_sort | Wanyu Jia |
| collection | DOAJ |
| description | AbstractThe purpose was to investigate how well age-adjusted modified quick Sequential Organ Failure Assessment (qSOFA) scores paired with blood glucose and lactate levels predict the outcomes of septicemic children in the pediatric intensive care unit (PICU). One hundred children who were diagnosed with sepsis and septic shock in the PICU of Henan Children’s Hospital were eligible, and other 20 patients in the same hospital at different times were selected as a validation set. Respiratory rate (RR), heart rate (HR), capillary refill time (CRT), and Alert, Voice, Pain, Unresponsive (AVPU) scale were included in the age-adjusted modified qSOFA scoring criteria for scoring. The primary outcome was 28-day all-cause mortality. The predictive values were evaluated by the ROC curve. In the sepsis group, 50 patients were male, and 50 patients were female. The 28-day all-cause mortality rate was 52%. Fifty-one patients with age-adjusted modified qSOFA scores >1. The serum lactate level was 2.4 mmol/L, and the blood glucose level was 9.3 mmol/L. The AUCs for the age-adjusted modified qSOFA score, serum lactate and blood glucose levels for the prediction of 28-day all-cause mortality in children with sepsis were 0.719, 0.719 and 0.737, respectively. The cut-off values were one point, 3.8 mmol/L and 10 mmol/L, respectively. The AUC of the age-adjusted modified qSOFA score for the validation set of was 0.925. When the three indices were combined, the AUC was 0.817, the Hosmer–Lemeshow goodness-of-fit test showed χ2 = 2.428 and p = .965. When children with sepsis are admitted to the ICU, we recommend performing rapid scoring and rapid bedside lactate and glucose testing to determine the early prognosis. |
| first_indexed | 2024-04-24T11:53:00Z |
| format | Article |
| id | doaj.art-2305ac0166454d409569d2e3526b822c |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-04-24T11:53:00Z |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-2305ac0166454d409569d2e3526b822c2024-04-09T06:13:02ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602024-12-0156110.1080/07853890.2024.2337714Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICUWanyu Jia0Xue Zhang1Ruiyang Sun2Peng Li3Daobin Wang4Xue Gu5Chunlan Song6Department of Emergency Medicine, Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, ChinaDepartment of Emergency Medicine, Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, ChinaDepartment of Emergency Medicine, Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, ChinaDepartment of Emergency Medicine, Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, ChinaDepartment of Pediatrics, Zhecheng County People’s Hospital, Shangqiu, ChinaDepartment of Emergency Medicine, Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, ChinaDepartment of Emergency Medicine, Henan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, ChinaAbstractThe purpose was to investigate how well age-adjusted modified quick Sequential Organ Failure Assessment (qSOFA) scores paired with blood glucose and lactate levels predict the outcomes of septicemic children in the pediatric intensive care unit (PICU). One hundred children who were diagnosed with sepsis and septic shock in the PICU of Henan Children’s Hospital were eligible, and other 20 patients in the same hospital at different times were selected as a validation set. Respiratory rate (RR), heart rate (HR), capillary refill time (CRT), and Alert, Voice, Pain, Unresponsive (AVPU) scale were included in the age-adjusted modified qSOFA scoring criteria for scoring. The primary outcome was 28-day all-cause mortality. The predictive values were evaluated by the ROC curve. In the sepsis group, 50 patients were male, and 50 patients were female. The 28-day all-cause mortality rate was 52%. Fifty-one patients with age-adjusted modified qSOFA scores >1. The serum lactate level was 2.4 mmol/L, and the blood glucose level was 9.3 mmol/L. The AUCs for the age-adjusted modified qSOFA score, serum lactate and blood glucose levels for the prediction of 28-day all-cause mortality in children with sepsis were 0.719, 0.719 and 0.737, respectively. The cut-off values were one point, 3.8 mmol/L and 10 mmol/L, respectively. The AUC of the age-adjusted modified qSOFA score for the validation set of was 0.925. When the three indices were combined, the AUC was 0.817, the Hosmer–Lemeshow goodness-of-fit test showed χ2 = 2.428 and p = .965. When children with sepsis are admitted to the ICU, we recommend performing rapid scoring and rapid bedside lactate and glucose testing to determine the early prognosis.https://www.tandfonline.com/doi/10.1080/07853890.2024.2337714Sepsisage-adjusted modified qSOFA28-day all-cause mortalityglucoselactate |
| spellingShingle | Wanyu Jia Xue Zhang Ruiyang Sun Peng Li Daobin Wang Xue Gu Chunlan Song Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICU Annals of Medicine Sepsis age-adjusted modified qSOFA 28-day all-cause mortality glucose lactate |
| title | Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICU |
| title_full | Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICU |
| title_fullStr | Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICU |
| title_full_unstemmed | Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICU |
| title_short | Value of modified qSOFA, glucose and lactate in predicting prognosis in children with sepsis in the PICU |
| title_sort | value of modified qsofa glucose and lactate in predicting prognosis in children with sepsis in the picu |
| topic | Sepsis age-adjusted modified qSOFA 28-day all-cause mortality glucose lactate |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2024.2337714 |
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