Cancer-Associated Fibroblasts in Cholangiocarcinoma: Current Knowledge and Possible Implications for Therapy

Cancer-Associated Fibroblasts in Cholangiocarcinoma: Current Knowledge and Possible Implications for Therapy

Cholangiocarcinoma (CCA) is an aggressive neoplasia with an increasing incidence and mortality. It is characterized by a strong desmoplastic stroma surrounding cancer cells. Cancer-associated fibroblasts (CAFs) are the main cell type of CCA stroma and they have an important role in modulating cancer...

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Bibliographic Details
Main Authors: Michele Montori, Chiara Scorzoni, Maria Eva Argenziano, Daniele Balducci, Federico De Blasio, Francesco Martini, Tiziana Buono, Antonio Benedetti, Marco Marzioni, Luca Maroni
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Journal of Clinical Medicine
Subjects:
CAF
cancer-associated fibroblast
cholangiocarcinoma
desmoplasia
α-SMA
stroma
Online Access:https://www.mdpi.com/2077-0383/11/21/6498

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