Тіе Modern treatment of androgenetic alopecia
Androgenetic alopecia (AGA) is the most common reason for hair loss. Its frequency in Caucasian population is up to 80% in men and 42% in women. Current gold standard for AGA treatment includes minoxidil and/or finasteride. Both drugs have moderate treatment efficacy and can cause significant side e...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
State Scientific Center of Dermatovenereology and Cosmetology
2017-08-01
|
| Series: | Vestnik Dermatologii i Venerologii |
| Subjects: | |
| Online Access: | https://www.vestnikdv.ru/jour/article/view/293 |
| _version_ | 1797707906795175936 |
|---|---|
| author | V. K. Karnaukhov A. A. Lukyanova M. I. Lukashina E. S. Vorobeva I. M. Afanasov |
| author_facet | V. K. Karnaukhov A. A. Lukyanova M. I. Lukashina E. S. Vorobeva I. M. Afanasov |
| author_sort | V. K. Karnaukhov |
| collection | DOAJ |
| description | Androgenetic alopecia (AGA) is the most common reason for hair loss. Its frequency in Caucasian population is up to 80% in men and 42% in women. Current gold standard for AGA treatment includes minoxidil and/or finasteride. Both drugs have moderate treatment efficacy and can cause significant side effects. Minoxidil is the only option for treatment of AGA in women since finasteride has no efficacy. This review considers actual concepts of molecular mechanisms of pathogenesis and current treatment options of AGA with their limitations and shortcomings. Current state and perspectives of novel approaches to AGA treatment, potentially more effective and safe than minoxidil and finasteride, are described. The review discusses growth factors and cytokines, topical 5-alpha-reductase inhibitors, androgen receptor antagonists, prostaglandin analogs and antagonists, Wnt signaling activators and platelet-rich plasma injections. |
| first_indexed | 2024-03-12T06:14:25Z |
| format | Article |
| id | doaj.art-230aa174a8ef4e0fa21efca6bcd3ff2f |
| institution | Directory Open Access Journal |
| issn | 0042-4609 2313-6294 |
| language | English |
| last_indexed | 2024-03-12T06:14:25Z |
| publishDate | 2017-08-01 |
| publisher | State Scientific Center of Dermatovenereology and Cosmetology |
| record_format | Article |
| series | Vestnik Dermatologii i Venerologii |
| spelling | doaj.art-230aa174a8ef4e0fa21efca6bcd3ff2f2023-09-03T02:44:24ZengState Scientific Center of Dermatovenereology and CosmetologyVestnik Dermatologii i Venerologii0042-46092313-62942017-08-0101213010.25208/0042-4609-2017-0-1-21-30292Тіе Modern treatment of androgenetic alopeciaV. K. Karnaukhov0A. A. Lukyanova1M. I. Lukashina2E. S. Vorobeva3I. M. Afanasov4Lomonosov Moscow State UniversityShkola stilistov PersonaFederal State Budget Institution of Sciences Institute of Gene Biology, Russian Academy of Sciences; The Russian National Research Medical University named after N.I. PirogovFederal State Budget Institution of Sciences Institute of Gene Biology, Russian Academy of SciencesOOO ”DzhiJef Grupp”Androgenetic alopecia (AGA) is the most common reason for hair loss. Its frequency in Caucasian population is up to 80% in men and 42% in women. Current gold standard for AGA treatment includes minoxidil and/or finasteride. Both drugs have moderate treatment efficacy and can cause significant side effects. Minoxidil is the only option for treatment of AGA in women since finasteride has no efficacy. This review considers actual concepts of molecular mechanisms of pathogenesis and current treatment options of AGA with their limitations and shortcomings. Current state and perspectives of novel approaches to AGA treatment, potentially more effective and safe than minoxidil and finasteride, are described. The review discusses growth factors and cytokines, topical 5-alpha-reductase inhibitors, androgen receptor antagonists, prostaglandin analogs and antagonists, Wnt signaling activators and platelet-rich plasma injections.https://www.vestnikdv.ru/jour/article/view/293андрогенетическая алопецияминоксидилфинастеридфакторы роста и цитокиныпростагландиныобогащенная тромбоцитами плазмаandrogenetic alopeciaminoxidilfinasteridegrowth factors and cytokinesprostaglandinsplatelet-rich plasmaandrogenetic alopeciaminoxidilfinasteridegrowth factors and cytokinesprostaglandinsplatelet-rich plasma |
| spellingShingle | V. K. Karnaukhov A. A. Lukyanova M. I. Lukashina E. S. Vorobeva I. M. Afanasov Тіе Modern treatment of androgenetic alopecia Vestnik Dermatologii i Venerologii андрогенетическая алопеция миноксидил финастерид факторы роста и цитокины простагландины обогащенная тромбоцитами плазма androgenetic alopecia minoxidil finasteride growth factors and cytokines prostaglandins platelet-rich plasma androgenetic alopecia minoxidil finasteride growth factors and cytokines prostaglandins platelet-rich plasma |
| title | Тіе Modern treatment of androgenetic alopecia |
| title_full | Тіе Modern treatment of androgenetic alopecia |
| title_fullStr | Тіе Modern treatment of androgenetic alopecia |
| title_full_unstemmed | Тіе Modern treatment of androgenetic alopecia |
| title_short | Тіе Modern treatment of androgenetic alopecia |
| title_sort | тіе modern treatment of androgenetic alopecia |
| topic | андрогенетическая алопеция миноксидил финастерид факторы роста и цитокины простагландины обогащенная тромбоцитами плазма androgenetic alopecia minoxidil finasteride growth factors and cytokines prostaglandins platelet-rich plasma androgenetic alopecia minoxidil finasteride growth factors and cytokines prostaglandins platelet-rich plasma |
| url | https://www.vestnikdv.ru/jour/article/view/293 |
| work_keys_str_mv | AT vkkarnaukhov tíemoderntreatmentofandrogeneticalopecia AT aalukyanova tíemoderntreatmentofandrogeneticalopecia AT milukashina tíemoderntreatmentofandrogeneticalopecia AT esvorobeva tíemoderntreatmentofandrogeneticalopecia AT imafanasov tíemoderntreatmentofandrogeneticalopecia |