Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases?
Billions of cells undergo turnover and die via apoptosis throughout our lifetime. A prompt clearance of these apoptotic cells and debris by phagocytic cells, a process known as efferocytosis, is important in maintaining tissue homeostasis. Accordingly, impaired efferocytosis due to the defective cle...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-06-01
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| Series: | Molecular Therapy: Oncolytics |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2372770520300607 |
| _version_ | 1828424277478604800 |
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| author | Danfeng Lin Xiaodiao Kang Lu Shen Sheng Tu Cameron Lenahan Yiding Chen Xiaochen Wang Anwen Shao |
| author_facet | Danfeng Lin Xiaodiao Kang Lu Shen Sheng Tu Cameron Lenahan Yiding Chen Xiaochen Wang Anwen Shao |
| author_sort | Danfeng Lin |
| collection | DOAJ |
| description | Billions of cells undergo turnover and die via apoptosis throughout our lifetime. A prompt clearance of these apoptotic cells and debris by phagocytic cells, a process known as efferocytosis, is important in maintaining tissue homeostasis. Accordingly, impaired efferocytosis due to the defective clearance and disrupted stages can lead to a growing number of inflammation- and immune-related diseases. Although numerous studies have shown the mechanisms of efferocytosis, its role in disorders, such as non-tumor and tumor diseases, remains poorly understood. This review summarizes the processes and signal molecules in efferocytosis, and efferocytosis-related functions in non-tumor (e.g., atherosclerosis, lung diseases) and tumor diseases (e.g., breast cancer, prostate cancer), as well as describes the role of involved cytokines. Of note, there is a dual role of efferocytosis in the abovementioned disorders, and a paradoxical effect among non-tumor and tumor diseases in terms of inflammation resolution, immune response, and disease progression. Briefly, intact efferocytosis and cytokines promote tissue repair, while they contribute to tumor progression via the tumor microenvironment and macrophage politzerization. Additionally, this review provides potential targets associated with TAM (TYRO3, AXL, MERTK) receptors and cytokines, such as tumor necrosis factor α and CXCL5, suggesting potential novel therapeutic ways in treating diseases. |
| first_indexed | 2024-12-10T16:15:34Z |
| format | Article |
| id | doaj.art-230b63e7c2144767aeeadea3ff53016b |
| institution | Directory Open Access Journal |
| issn | 2372-7705 |
| language | English |
| last_indexed | 2024-12-10T16:15:34Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Molecular Therapy: Oncolytics |
| spelling | doaj.art-230b63e7c2144767aeeadea3ff53016b2022-12-22T01:41:58ZengElsevierMolecular Therapy: Oncolytics2372-77052020-06-0117394407Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases?Danfeng Lin0Xiaodiao Kang1Lu Shen2Sheng Tu3Cameron Lenahan4Yiding Chen5Xiaochen Wang6Anwen Shao7Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Orthopedics Surgery, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, ChinaDepartment of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaState Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, ChinaBurrell College of Osteopathic Medicine, Las Cruces, NM, USA; Center for Neuroscience Research, School of Medicine, Loma Linda University, CA, USADepartment of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author: Yiding Chen, Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Breast Surgery, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, China; Corresponding author: Xiaochen Wang, Department of Surgical Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Corresponding author: Anwen Shao, Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.Billions of cells undergo turnover and die via apoptosis throughout our lifetime. A prompt clearance of these apoptotic cells and debris by phagocytic cells, a process known as efferocytosis, is important in maintaining tissue homeostasis. Accordingly, impaired efferocytosis due to the defective clearance and disrupted stages can lead to a growing number of inflammation- and immune-related diseases. Although numerous studies have shown the mechanisms of efferocytosis, its role in disorders, such as non-tumor and tumor diseases, remains poorly understood. This review summarizes the processes and signal molecules in efferocytosis, and efferocytosis-related functions in non-tumor (e.g., atherosclerosis, lung diseases) and tumor diseases (e.g., breast cancer, prostate cancer), as well as describes the role of involved cytokines. Of note, there is a dual role of efferocytosis in the abovementioned disorders, and a paradoxical effect among non-tumor and tumor diseases in terms of inflammation resolution, immune response, and disease progression. Briefly, intact efferocytosis and cytokines promote tissue repair, while they contribute to tumor progression via the tumor microenvironment and macrophage politzerization. Additionally, this review provides potential targets associated with TAM (TYRO3, AXL, MERTK) receptors and cytokines, such as tumor necrosis factor α and CXCL5, suggesting potential novel therapeutic ways in treating diseases.http://www.sciencedirect.com/science/article/pii/S2372770520300607efferocytosisinflammationcytokineatherosclerosislung diseasetumor |
| spellingShingle | Danfeng Lin Xiaodiao Kang Lu Shen Sheng Tu Cameron Lenahan Yiding Chen Xiaochen Wang Anwen Shao Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases? Molecular Therapy: Oncolytics efferocytosis inflammation cytokine atherosclerosis lung disease tumor |
| title | Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases? |
| title_full | Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases? |
| title_fullStr | Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases? |
| title_full_unstemmed | Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases? |
| title_short | Efferocytosis and Its Associated Cytokines: A Light on Non-tumor and Tumor Diseases? |
| title_sort | efferocytosis and its associated cytokines a light on non tumor and tumor diseases |
| topic | efferocytosis inflammation cytokine atherosclerosis lung disease tumor |
| url | http://www.sciencedirect.com/science/article/pii/S2372770520300607 |
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