Vitamin A intake and risk of melanoma: a meta-analysis.
BACKGROUND: Mounting evidence from experimental and animal studies suggests that vitamin A may have a protective effect on melanoma, but the findings on the association of vitamin A intake with risk of melanoma have been inconsistently reported in epidemiologic studies. We attempted to elucidate the...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4105469?pdf=render |
| _version_ | 1818173681449304064 |
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| author | Yun-Ping Zhang Rui-Xue Chu Hui Liu |
| author_facet | Yun-Ping Zhang Rui-Xue Chu Hui Liu |
| author_sort | Yun-Ping Zhang |
| collection | DOAJ |
| description | BACKGROUND: Mounting evidence from experimental and animal studies suggests that vitamin A may have a protective effect on melanoma, but the findings on the association of vitamin A intake with risk of melanoma have been inconsistently reported in epidemiologic studies. We attempted to elucidate the association by performing a meta-analysis. METHODS: Eligible studies were identified by searching PubMed and EMBASE databases, as well as by reviewing the references of retrieved publications. Summary odds ratios (OR) with corresponding 95% confidence interval (CI) were computed with a random-effects model. Study-specific ORs and 95% CIs for the highest vs. lowest categories of vitamin A intake were pooled. RESULTS: A total of 8 case-control studies and 2 prospective studies comprising 3,328 melanoma cases and 233,295 non-case subjects were included. The summary OR for the highest compared with the lowest intake of total vitamin A, retinol and beta-carotene was 0.86 (95% CI = 0.59-1.25), 0.80 (95% CI = 0.69-0.92) and 0.87 (95%CI = 0.62-1.20), respectively. Significant heterogeneity was observed among studies on vitamin A and beta-carotene intake, but not among studies on retinol intake. Subgroup and sensitivity analyses confirmed these findings. There was no indication of publication bias. CONCLUSION: Findings from this meta-analysis suggest that intake of retinol, rather than of total vitamin A or beta-carotene, is significantly associated with reduced risk of melanoma. |
| first_indexed | 2024-12-11T19:32:22Z |
| format | Article |
| id | doaj.art-230c89c0e85e4d8fb508e98dd388b8dd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T19:32:22Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-230c89c0e85e4d8fb508e98dd388b8dd2022-12-22T00:53:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10252710.1371/journal.pone.0102527Vitamin A intake and risk of melanoma: a meta-analysis.Yun-Ping ZhangRui-Xue ChuHui LiuBACKGROUND: Mounting evidence from experimental and animal studies suggests that vitamin A may have a protective effect on melanoma, but the findings on the association of vitamin A intake with risk of melanoma have been inconsistently reported in epidemiologic studies. We attempted to elucidate the association by performing a meta-analysis. METHODS: Eligible studies were identified by searching PubMed and EMBASE databases, as well as by reviewing the references of retrieved publications. Summary odds ratios (OR) with corresponding 95% confidence interval (CI) were computed with a random-effects model. Study-specific ORs and 95% CIs for the highest vs. lowest categories of vitamin A intake were pooled. RESULTS: A total of 8 case-control studies and 2 prospective studies comprising 3,328 melanoma cases and 233,295 non-case subjects were included. The summary OR for the highest compared with the lowest intake of total vitamin A, retinol and beta-carotene was 0.86 (95% CI = 0.59-1.25), 0.80 (95% CI = 0.69-0.92) and 0.87 (95%CI = 0.62-1.20), respectively. Significant heterogeneity was observed among studies on vitamin A and beta-carotene intake, but not among studies on retinol intake. Subgroup and sensitivity analyses confirmed these findings. There was no indication of publication bias. CONCLUSION: Findings from this meta-analysis suggest that intake of retinol, rather than of total vitamin A or beta-carotene, is significantly associated with reduced risk of melanoma.http://europepmc.org/articles/PMC4105469?pdf=render |
| spellingShingle | Yun-Ping Zhang Rui-Xue Chu Hui Liu Vitamin A intake and risk of melanoma: a meta-analysis. PLoS ONE |
| title | Vitamin A intake and risk of melanoma: a meta-analysis. |
| title_full | Vitamin A intake and risk of melanoma: a meta-analysis. |
| title_fullStr | Vitamin A intake and risk of melanoma: a meta-analysis. |
| title_full_unstemmed | Vitamin A intake and risk of melanoma: a meta-analysis. |
| title_short | Vitamin A intake and risk of melanoma: a meta-analysis. |
| title_sort | vitamin a intake and risk of melanoma a meta analysis |
| url | http://europepmc.org/articles/PMC4105469?pdf=render |
| work_keys_str_mv | AT yunpingzhang vitaminaintakeandriskofmelanomaametaanalysis AT ruixuechu vitaminaintakeandriskofmelanomaametaanalysis AT huiliu vitaminaintakeandriskofmelanomaametaanalysis |