Inositol Phosphates and Retroviral Assembly: A Cellular Perspective
Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been made in retroviral research. In this review, th...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-12-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/13/12/2516 |
| _version_ | 1797499886949629952 |
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| author | Clifton L. Ricaña Robert A. Dick |
| author_facet | Clifton L. Ricaña Robert A. Dick |
| author_sort | Clifton L. Ricaña |
| collection | DOAJ |
| description | Understanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been made in retroviral research. In this review, the enzymatic pathways to synthesize and metabolize inositol phosphates (IPs) relevant to retroviral assembly are discussed. The functions of these enzymes and IPs are outlined in the context of the cellular biology important for retroviruses. Lastly, the recent advances in understanding the role of IPs in retroviral biology are surveyed. |
| first_indexed | 2024-03-10T03:53:52Z |
| format | Article |
| id | doaj.art-230ca6c9cef94604bb7effcbe8834eff |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T03:53:52Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-230ca6c9cef94604bb7effcbe8834eff2023-11-23T10:59:01ZengMDPI AGViruses1999-49152021-12-011312251610.3390/v13122516Inositol Phosphates and Retroviral Assembly: A Cellular PerspectiveClifton L. Ricaña0Robert A. Dick1Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USADepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853, USAUnderstanding the molecular mechanisms of retroviral assembly has been a decades-long endeavor. With the recent discovery of inositol hexakisphosphate (IP6) acting as an assembly co-factor for human immunodeficiency virus (HIV), great strides have been made in retroviral research. In this review, the enzymatic pathways to synthesize and metabolize inositol phosphates (IPs) relevant to retroviral assembly are discussed. The functions of these enzymes and IPs are outlined in the context of the cellular biology important for retroviruses. Lastly, the recent advances in understanding the role of IPs in retroviral biology are surveyed.https://www.mdpi.com/1999-4915/13/12/2516HIVlentivirusinositol hexakisphosphateInsP6IP6InsP5 |
| spellingShingle | Clifton L. Ricaña Robert A. Dick Inositol Phosphates and Retroviral Assembly: A Cellular Perspective Viruses HIV lentivirus inositol hexakisphosphate InsP6 IP6 InsP5 |
| title | Inositol Phosphates and Retroviral Assembly: A Cellular Perspective |
| title_full | Inositol Phosphates and Retroviral Assembly: A Cellular Perspective |
| title_fullStr | Inositol Phosphates and Retroviral Assembly: A Cellular Perspective |
| title_full_unstemmed | Inositol Phosphates and Retroviral Assembly: A Cellular Perspective |
| title_short | Inositol Phosphates and Retroviral Assembly: A Cellular Perspective |
| title_sort | inositol phosphates and retroviral assembly a cellular perspective |
| topic | HIV lentivirus inositol hexakisphosphate InsP6 IP6 InsP5 |
| url | https://www.mdpi.com/1999-4915/13/12/2516 |
| work_keys_str_mv | AT cliftonlricana inositolphosphatesandretroviralassemblyacellularperspective AT robertadick inositolphosphatesandretroviralassemblyacellularperspective |