Antimicrobial Peptides and Cationic Nanoparticles: A Broad-Spectrum Weapon to Fight Multi-Drug Resistance Not Only in Bacteria
In the last few years, antibiotic resistance and, analogously, anticancer drug resistance have increased considerably, becoming one of the main public health problems. For this reason, it is crucial to find therapeutic strategies able to counteract the onset of multi-drug resistance (MDR). In this r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/11/6108 |
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| author | Giulia E. Valenti Silvana Alfei Debora Caviglia Cinzia Domenicotti Barbara Marengo |
| author_facet | Giulia E. Valenti Silvana Alfei Debora Caviglia Cinzia Domenicotti Barbara Marengo |
| author_sort | Giulia E. Valenti |
| collection | DOAJ |
| description | In the last few years, antibiotic resistance and, analogously, anticancer drug resistance have increased considerably, becoming one of the main public health problems. For this reason, it is crucial to find therapeutic strategies able to counteract the onset of multi-drug resistance (MDR). In this review, a critical overview of the innovative tools available today to fight MDR is reported. In this direction, the use of membrane-disruptive peptides/peptidomimetics (MDPs), such as antimicrobial peptides (AMPs), has received particular attention, due to their high selectivity and to their limited side effects. Moreover, similarities between bacteria and cancer cells are herein reported and the hypothesis of the possible use of AMPs also in anticancer therapies is discussed. However, it is important to take into account the limitations that could negatively impact clinical application and, in particular, the need for an efficient delivery system. In this regard, the use of nanoparticles (NPs) is proposed as a potential strategy to improve therapy; moreover, among polymeric NPs, cationic ones are emerging as promising tools able to fight the onset of MDR both in bacteria and in cancer cells. |
| first_indexed | 2024-03-10T01:14:53Z |
| format | Article |
| id | doaj.art-230e27ac964845a782b476f235fe65a4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T01:14:53Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-230e27ac964845a782b476f235fe65a42023-11-23T14:09:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-012311610810.3390/ijms23116108Antimicrobial Peptides and Cationic Nanoparticles: A Broad-Spectrum Weapon to Fight Multi-Drug Resistance Not Only in BacteriaGiulia E. Valenti0Silvana Alfei1Debora Caviglia2Cinzia Domenicotti3Barbara Marengo4Department of Experimental Medicine (DIMES), General Pathology Section, University of Genoa, 16132 Genoa, ItalyDepartment of Pharmacy, University of Genoa, 16148 Genoa, ItalyDepartment of Surgical Sciences and Integrated Diagnostics (DISC), University of Genoa, Viale Benedetto XV, 6, 16132 Genova, ItalyDepartment of Experimental Medicine (DIMES), General Pathology Section, University of Genoa, 16132 Genoa, ItalyDepartment of Experimental Medicine (DIMES), General Pathology Section, University of Genoa, 16132 Genoa, ItalyIn the last few years, antibiotic resistance and, analogously, anticancer drug resistance have increased considerably, becoming one of the main public health problems. For this reason, it is crucial to find therapeutic strategies able to counteract the onset of multi-drug resistance (MDR). In this review, a critical overview of the innovative tools available today to fight MDR is reported. In this direction, the use of membrane-disruptive peptides/peptidomimetics (MDPs), such as antimicrobial peptides (AMPs), has received particular attention, due to their high selectivity and to their limited side effects. Moreover, similarities between bacteria and cancer cells are herein reported and the hypothesis of the possible use of AMPs also in anticancer therapies is discussed. However, it is important to take into account the limitations that could negatively impact clinical application and, in particular, the need for an efficient delivery system. In this regard, the use of nanoparticles (NPs) is proposed as a potential strategy to improve therapy; moreover, among polymeric NPs, cationic ones are emerging as promising tools able to fight the onset of MDR both in bacteria and in cancer cells.https://www.mdpi.com/1422-0067/23/11/6108multi-drug resistanceantibioticsanticancer drugsantimicrobial peptidescationic nanoparticles |
| spellingShingle | Giulia E. Valenti Silvana Alfei Debora Caviglia Cinzia Domenicotti Barbara Marengo Antimicrobial Peptides and Cationic Nanoparticles: A Broad-Spectrum Weapon to Fight Multi-Drug Resistance Not Only in Bacteria International Journal of Molecular Sciences multi-drug resistance antibiotics anticancer drugs antimicrobial peptides cationic nanoparticles |
| title | Antimicrobial Peptides and Cationic Nanoparticles: A Broad-Spectrum Weapon to Fight Multi-Drug Resistance Not Only in Bacteria |
| title_full | Antimicrobial Peptides and Cationic Nanoparticles: A Broad-Spectrum Weapon to Fight Multi-Drug Resistance Not Only in Bacteria |
| title_fullStr | Antimicrobial Peptides and Cationic Nanoparticles: A Broad-Spectrum Weapon to Fight Multi-Drug Resistance Not Only in Bacteria |
| title_full_unstemmed | Antimicrobial Peptides and Cationic Nanoparticles: A Broad-Spectrum Weapon to Fight Multi-Drug Resistance Not Only in Bacteria |
| title_short | Antimicrobial Peptides and Cationic Nanoparticles: A Broad-Spectrum Weapon to Fight Multi-Drug Resistance Not Only in Bacteria |
| title_sort | antimicrobial peptides and cationic nanoparticles a broad spectrum weapon to fight multi drug resistance not only in bacteria |
| topic | multi-drug resistance antibiotics anticancer drugs antimicrobial peptides cationic nanoparticles |
| url | https://www.mdpi.com/1422-0067/23/11/6108 |
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