Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer?
Obesity is a complex and multifactorial problem of global importance. Additionally, obesity causes chronic inflammation, upregulates cell growth, disturbs the immune system, and causes genomic instability, increasing the risk of carcinogenesis. Colorectal cancer is one of the most common cancers, an...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/7/2451 |
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| author | Anna Maria Rychter Liliana Łykowska-Szuber Agnieszka Zawada Aleksandra Szymczak-Tomczak Alicja Ewa Ratajczak Kinga Skoracka Michalina Kolan Agnieszka Dobrowolska Iwona Krela-Kaźmierczak |
| author_facet | Anna Maria Rychter Liliana Łykowska-Szuber Agnieszka Zawada Aleksandra Szymczak-Tomczak Alicja Ewa Ratajczak Kinga Skoracka Michalina Kolan Agnieszka Dobrowolska Iwona Krela-Kaźmierczak |
| author_sort | Anna Maria Rychter |
| collection | DOAJ |
| description | Obesity is a complex and multifactorial problem of global importance. Additionally, obesity causes chronic inflammation, upregulates cell growth, disturbs the immune system, and causes genomic instability, increasing the risk of carcinogenesis. Colorectal cancer is one of the most common cancers, and it has become a global problem. In 2018, there were around 1.8 million new cases and around 881,000 deaths worldwide. Another risk factor of colorectal cancer associated with obesity is poor diet. A Western diet, including a high intake of red and processed meat and a low consumption of whole grains, fruits, vegetables, and fiber, may increase the risk of both colorectal cancer and obesity. Moreover, the Western diet is associated with a proinflammatory profile diet, which may also affect chronic low-grade inflammation. In fact, people with obesity often present gut dysbiosis, increased inflammation, and risk of colorectal cancer. In this article, the association between obesity and colorectal cancer is discussed, including the most important mechanisms, such as low-grade chronic inflammation, gut dysbiosis, and poor diet. |
| first_indexed | 2024-03-11T05:33:29Z |
| format | Article |
| id | doaj.art-23102cb23abd45cb999a49a8f3e21cee |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T05:33:29Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-23102cb23abd45cb999a49a8f3e21cee2023-11-17T16:57:18ZengMDPI AGJournal of Clinical Medicine2077-03832023-03-01127245110.3390/jcm12072451Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer?Anna Maria Rychter0Liliana Łykowska-Szuber1Agnieszka Zawada2Aleksandra Szymczak-Tomczak3Alicja Ewa Ratajczak4Kinga Skoracka5Michalina Kolan6Agnieszka Dobrowolska7Iwona Krela-Kaźmierczak8Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, PolandDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, PolandDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, PolandDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, PolandDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, PolandDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, PolandFaculty of Medicine Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, 85-094 Bydgoszcz, PolandDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, PolandDepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, PolandObesity is a complex and multifactorial problem of global importance. Additionally, obesity causes chronic inflammation, upregulates cell growth, disturbs the immune system, and causes genomic instability, increasing the risk of carcinogenesis. Colorectal cancer is one of the most common cancers, and it has become a global problem. In 2018, there were around 1.8 million new cases and around 881,000 deaths worldwide. Another risk factor of colorectal cancer associated with obesity is poor diet. A Western diet, including a high intake of red and processed meat and a low consumption of whole grains, fruits, vegetables, and fiber, may increase the risk of both colorectal cancer and obesity. Moreover, the Western diet is associated with a proinflammatory profile diet, which may also affect chronic low-grade inflammation. In fact, people with obesity often present gut dysbiosis, increased inflammation, and risk of colorectal cancer. In this article, the association between obesity and colorectal cancer is discussed, including the most important mechanisms, such as low-grade chronic inflammation, gut dysbiosis, and poor diet.https://www.mdpi.com/2077-0383/12/7/2451obesityinflammationcolorectal cancerdietgut microbiota |
| spellingShingle | Anna Maria Rychter Liliana Łykowska-Szuber Agnieszka Zawada Aleksandra Szymczak-Tomczak Alicja Ewa Ratajczak Kinga Skoracka Michalina Kolan Agnieszka Dobrowolska Iwona Krela-Kaźmierczak Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer? Journal of Clinical Medicine obesity inflammation colorectal cancer diet gut microbiota |
| title | Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer? |
| title_full | Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer? |
| title_fullStr | Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer? |
| title_full_unstemmed | Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer? |
| title_short | Why Does Obesity as an Inflammatory Condition Predispose to Colorectal Cancer? |
| title_sort | why does obesity as an inflammatory condition predispose to colorectal cancer |
| topic | obesity inflammation colorectal cancer diet gut microbiota |
| url | https://www.mdpi.com/2077-0383/12/7/2451 |
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