A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy
Duchenne muscular dystrophy (DMD) is a muscular disease characterized by progressive muscle degeneration. Life expectancy is between 30 and 50 years, and death is correlated with cardiac or respiratory complications. Currently, there is no cure, so there is a great interest in new pharmacological ta...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/6/1380 |
| _version_ | 1797531495528660992 |
|---|---|
| author | Elisa Domi Malvina Hoxha Emanuela Prendi Bruno Zappacosta |
| author_facet | Elisa Domi Malvina Hoxha Emanuela Prendi Bruno Zappacosta |
| author_sort | Elisa Domi |
| collection | DOAJ |
| description | Duchenne muscular dystrophy (DMD) is a muscular disease characterized by progressive muscle degeneration. Life expectancy is between 30 and 50 years, and death is correlated with cardiac or respiratory complications. Currently, there is no cure, so there is a great interest in new pharmacological targets. Sirtuin1 (SIRT1) seems to be a potential target for DMD. In muscle tissue, SIRT1 exerts anti-inflammatory and antioxidant effects. The aim of this study is to summarize all the findings of in vivo and in vitro literature studies about the potential role of SIRT1 in DMD. A systematic literature search was performed according to PRISMA guidelines. Twenty-three articles satisfied the eligibility criteria. It emerged that SIRT1 inhibition led to muscle fragility, while conversely its activation improved muscle function. Additionally, resveratrol, a SIRT1 activator, has brought beneficial effects to the skeletal, cardiac and respiratory muscles by exerting anti-inflammatory activity that leads to reduced myofiber wasting. |
| first_indexed | 2024-03-10T10:44:36Z |
| format | Article |
| id | doaj.art-2310c8140fe5474c9e5f871636a7d0d7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T10:44:36Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-2310c8140fe5474c9e5f871636a7d0d72023-11-21T22:39:55ZengMDPI AGCells2073-44092021-06-01106138010.3390/cells10061380A Systematic Review on the Role of SIRT1 in Duchenne Muscular DystrophyElisa Domi0Malvina Hoxha1Emanuela Prendi2Bruno Zappacosta3Department for Chemical-Toxicological and Pharmacological Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, Rruga Dritan Hoxha, Tirana 1000, AlbaniaDepartment for Chemical-Toxicological and Pharmacological Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, Rruga Dritan Hoxha, Tirana 1000, AlbaniaDepartment of Biomedical Sciences, Faculty of Medicine, Catholic University Our Lady of Good Counsel, Rruga Dritan Hoxha, Tirana 1000, AlbaniaDepartment for Chemical-Toxicological and Pharmacological Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, Rruga Dritan Hoxha, Tirana 1000, AlbaniaDuchenne muscular dystrophy (DMD) is a muscular disease characterized by progressive muscle degeneration. Life expectancy is between 30 and 50 years, and death is correlated with cardiac or respiratory complications. Currently, there is no cure, so there is a great interest in new pharmacological targets. Sirtuin1 (SIRT1) seems to be a potential target for DMD. In muscle tissue, SIRT1 exerts anti-inflammatory and antioxidant effects. The aim of this study is to summarize all the findings of in vivo and in vitro literature studies about the potential role of SIRT1 in DMD. A systematic literature search was performed according to PRISMA guidelines. Twenty-three articles satisfied the eligibility criteria. It emerged that SIRT1 inhibition led to muscle fragility, while conversely its activation improved muscle function. Additionally, resveratrol, a SIRT1 activator, has brought beneficial effects to the skeletal, cardiac and respiratory muscles by exerting anti-inflammatory activity that leads to reduced myofiber wasting.https://www.mdpi.com/2073-4409/10/6/1380Duchenne muscular dystrophysirtuin1inflammation |
| spellingShingle | Elisa Domi Malvina Hoxha Emanuela Prendi Bruno Zappacosta A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy Cells Duchenne muscular dystrophy sirtuin1 inflammation |
| title | A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy |
| title_full | A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy |
| title_fullStr | A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy |
| title_full_unstemmed | A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy |
| title_short | A Systematic Review on the Role of SIRT1 in Duchenne Muscular Dystrophy |
| title_sort | systematic review on the role of sirt1 in duchenne muscular dystrophy |
| topic | Duchenne muscular dystrophy sirtuin1 inflammation |
| url | https://www.mdpi.com/2073-4409/10/6/1380 |
| work_keys_str_mv | AT elisadomi asystematicreviewontheroleofsirt1induchennemusculardystrophy AT malvinahoxha asystematicreviewontheroleofsirt1induchennemusculardystrophy AT emanuelaprendi asystematicreviewontheroleofsirt1induchennemusculardystrophy AT brunozappacosta asystematicreviewontheroleofsirt1induchennemusculardystrophy AT elisadomi systematicreviewontheroleofsirt1induchennemusculardystrophy AT malvinahoxha systematicreviewontheroleofsirt1induchennemusculardystrophy AT emanuelaprendi systematicreviewontheroleofsirt1induchennemusculardystrophy AT brunozappacosta systematicreviewontheroleofsirt1induchennemusculardystrophy |