Helicobacter pylori among patients with symptoms of gastroduodenal ulcer disease in rural Uganda
Introduction: To meet key millennium development goals, the rural population needs to be reached for health assessment and service delivery. Gastroduodenal ulcer disease is a common ailment affecting the health of people in Uganda. A cross-sectional study was conducted at Bwera Hospital in Kasese di...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2015-11-01
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| Series: | Infection Ecology & Epidemiology |
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| Online Access: | http://www.infectionecologyandepidemiology.net/index.php/iee/article/view/26785/pdf_35 |
| _version_ | 1830483239154745344 |
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| author | Lawrence Tsongo Jessica Nakavuma Claire Mugasa Edwin Kamalha |
| author_facet | Lawrence Tsongo Jessica Nakavuma Claire Mugasa Edwin Kamalha |
| author_sort | Lawrence Tsongo |
| collection | DOAJ |
| description | Introduction: To meet key millennium development goals, the rural population needs to be reached for health assessment and service delivery. Gastroduodenal ulcer disease is a common ailment affecting the health of people in Uganda. A cross-sectional study was conducted at Bwera Hospital in Kasese district of western Uganda, to establish the prevalence and predisposing factors of Helicobacter pylori among gastroduodenal ulcer disease patients. Methods: A sample of 174 patients with symptoms of gastroduodenal ulcer disease was purposively obtained. Using two laboratory test methods, the prevalence of H. pylori among these patients was determined. A structured questionnaire was administered to participants to establish their demographic background and selected aspects of their lifestyle. Finally, the results obtained by enzyme-linked immunosorbent assay (ELISA) and immunochromatographic rapid test (IRT) were compared. Results: We established the prevalence of H. pylori as 29.9% (52/174) by ELISA and 37.4% (65/174) by IRT. Cigarette smoking, poor sanitation, and lack of formal education were the significant predisposing factors with p-values <0.05. The two tests gave identical results in 87.9% of the patients. Discussion: The prevalence of H. pylori by IRT and ELISA test methods was similar to what has been reported elsewhere in developed countries; but was lower than previously reported in developing countries including Uganda. The previous studies in Uganda were carried out in the urban population and on young children; and some used antibody-detection methods only, therefore leading to different prevalence as a result of difference in study population and methods. |
| first_indexed | 2024-12-21T17:47:42Z |
| format | Article |
| id | doaj.art-23151159f6624b0d8d257abfb98501a4 |
| institution | Directory Open Access Journal |
| issn | 2000-8686 |
| language | English |
| last_indexed | 2024-12-21T17:47:42Z |
| publishDate | 2015-11-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Infection Ecology & Epidemiology |
| spelling | doaj.art-23151159f6624b0d8d257abfb98501a42022-12-21T18:55:26ZengTaylor & Francis GroupInfection Ecology & Epidemiology2000-86862015-11-01501610.3402/iee.v5.2678526785Helicobacter pylori among patients with symptoms of gastroduodenal ulcer disease in rural UgandaLawrence Tsongo0Jessica Nakavuma1Claire Mugasa2Edwin Kamalha3 College of Veterinary Medicine, School of Biosafety, Biosecurity and Biomedical Laboratory Sciences, Makerere University, Kampala, Uganda College of Veterinary Medicine, School of Biosafety, Biosecurity and Biomedical Laboratory Sciences, Makerere University, Kampala, Uganda College of Veterinary Medicine, School of Biosafety, Biosecurity and Biomedical Laboratory Sciences, Makerere University, Kampala, Uganda Faculty of Engineering, Busitema University, Tororo, UgandaIntroduction: To meet key millennium development goals, the rural population needs to be reached for health assessment and service delivery. Gastroduodenal ulcer disease is a common ailment affecting the health of people in Uganda. A cross-sectional study was conducted at Bwera Hospital in Kasese district of western Uganda, to establish the prevalence and predisposing factors of Helicobacter pylori among gastroduodenal ulcer disease patients. Methods: A sample of 174 patients with symptoms of gastroduodenal ulcer disease was purposively obtained. Using two laboratory test methods, the prevalence of H. pylori among these patients was determined. A structured questionnaire was administered to participants to establish their demographic background and selected aspects of their lifestyle. Finally, the results obtained by enzyme-linked immunosorbent assay (ELISA) and immunochromatographic rapid test (IRT) were compared. Results: We established the prevalence of H. pylori as 29.9% (52/174) by ELISA and 37.4% (65/174) by IRT. Cigarette smoking, poor sanitation, and lack of formal education were the significant predisposing factors with p-values <0.05. The two tests gave identical results in 87.9% of the patients. Discussion: The prevalence of H. pylori by IRT and ELISA test methods was similar to what has been reported elsewhere in developed countries; but was lower than previously reported in developing countries including Uganda. The previous studies in Uganda were carried out in the urban population and on young children; and some used antibody-detection methods only, therefore leading to different prevalence as a result of difference in study population and methods.http://www.infectionecologyandepidemiology.net/index.php/iee/article/view/26785/pdf_35Helicobacter pyloripeptic ulcerssymptomsgastroduodenal ulcerchronic gastritissmoking |
| spellingShingle | Lawrence Tsongo Jessica Nakavuma Claire Mugasa Edwin Kamalha Helicobacter pylori among patients with symptoms of gastroduodenal ulcer disease in rural Uganda Infection Ecology & Epidemiology Helicobacter pylori peptic ulcers symptoms gastroduodenal ulcer chronic gastritis smoking |
| title | Helicobacter pylori among patients with symptoms of gastroduodenal ulcer disease in rural Uganda |
| title_full | Helicobacter pylori among patients with symptoms of gastroduodenal ulcer disease in rural Uganda |
| title_fullStr | Helicobacter pylori among patients with symptoms of gastroduodenal ulcer disease in rural Uganda |
| title_full_unstemmed | Helicobacter pylori among patients with symptoms of gastroduodenal ulcer disease in rural Uganda |
| title_short | Helicobacter pylori among patients with symptoms of gastroduodenal ulcer disease in rural Uganda |
| title_sort | helicobacter pylori among patients with symptoms of gastroduodenal ulcer disease in rural uganda |
| topic | Helicobacter pylori peptic ulcers symptoms gastroduodenal ulcer chronic gastritis smoking |
| url | http://www.infectionecologyandepidemiology.net/index.php/iee/article/view/26785/pdf_35 |
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