Development of an interview-based warfarin nomogram predicting the time spent in the therapeutic INR range: A cost-effective, and non-invasive strategy building from a cross sectional study in a low resource setting
A cross-sectional study was conducted to predict time in therapeutic range (TTR) using clinical history, examination, and socioeconomic data. Study included warfarin-receiving patients from outpatient-clinic. In 203 patients studied, mean warfarin start-dose was 2.55 mg/day and maintenance-dose/week...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Indian Heart Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0019483222000529 |
| _version_ | 1818217051292958720 |
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| author | Aishwarya Anand Rupesh Kumar Ankur Gupta Rajesh Vijayvergiya Saurabh Mehrotra Deepesh Lad Parag Barwad Swati Sharma Amol N. Patil |
| author_facet | Aishwarya Anand Rupesh Kumar Ankur Gupta Rajesh Vijayvergiya Saurabh Mehrotra Deepesh Lad Parag Barwad Swati Sharma Amol N. Patil |
| author_sort | Aishwarya Anand |
| collection | DOAJ |
| description | A cross-sectional study was conducted to predict time in therapeutic range (TTR) using clinical history, examination, and socioeconomic data. Study included warfarin-receiving patients from outpatient-clinic. In 203 patients studied, mean warfarin start-dose was 2.55 mg/day and maintenance-dose/week was 30.79 mg. Body mass index (BMI) (p = 0.03), warfarin maintenance dose/day (p = 0.02), and comorbidity presence (p = 0.04) were significantly associated with TTR. Occupation (p = 0.53), income (p = 0.83), education (p = 0.55), and socioeconomic score (p = 0.73) showed non-significant association with TTR. A TTR predicting nomogram was built from clinical history and examination findings. |
| first_indexed | 2024-12-12T07:01:43Z |
| format | Article |
| id | doaj.art-2316312ed2344235a2c3046633a28ba1 |
| institution | Directory Open Access Journal |
| issn | 0019-4832 |
| language | English |
| last_indexed | 2024-12-12T07:01:43Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Indian Heart Journal |
| spelling | doaj.art-2316312ed2344235a2c3046633a28ba12022-12-22T00:33:50ZengElsevierIndian Heart Journal0019-48322022-05-01743245248Development of an interview-based warfarin nomogram predicting the time spent in the therapeutic INR range: A cost-effective, and non-invasive strategy building from a cross sectional study in a low resource settingAishwarya Anand0Rupesh Kumar1Ankur Gupta2Rajesh Vijayvergiya3Saurabh Mehrotra4Deepesh Lad5Parag Barwad6Swati Sharma7Amol N. Patil8Department of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Cardiothoracic and Vascular Surgery, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India; Co-Corresponding author. Department of Cardiology, PGIMER, Chandigarh, India.Department of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Internal Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Cardiology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, IndiaDepartment of Pharmacology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India; Corresponding author. Department of Pharmacology, PGIMER, Chandigarh, 160012, India.A cross-sectional study was conducted to predict time in therapeutic range (TTR) using clinical history, examination, and socioeconomic data. Study included warfarin-receiving patients from outpatient-clinic. In 203 patients studied, mean warfarin start-dose was 2.55 mg/day and maintenance-dose/week was 30.79 mg. Body mass index (BMI) (p = 0.03), warfarin maintenance dose/day (p = 0.02), and comorbidity presence (p = 0.04) were significantly associated with TTR. Occupation (p = 0.53), income (p = 0.83), education (p = 0.55), and socioeconomic score (p = 0.73) showed non-significant association with TTR. A TTR predicting nomogram was built from clinical history and examination findings.http://www.sciencedirect.com/science/article/pii/S0019483222000529Warfarin nomogramPercent time in therapeutic rangeINR |
| spellingShingle | Aishwarya Anand Rupesh Kumar Ankur Gupta Rajesh Vijayvergiya Saurabh Mehrotra Deepesh Lad Parag Barwad Swati Sharma Amol N. Patil Development of an interview-based warfarin nomogram predicting the time spent in the therapeutic INR range: A cost-effective, and non-invasive strategy building from a cross sectional study in a low resource setting Indian Heart Journal Warfarin nomogram Percent time in therapeutic range INR |
| title | Development of an interview-based warfarin nomogram predicting the time spent in the therapeutic INR range: A cost-effective, and non-invasive strategy building from a cross sectional study in a low resource setting |
| title_full | Development of an interview-based warfarin nomogram predicting the time spent in the therapeutic INR range: A cost-effective, and non-invasive strategy building from a cross sectional study in a low resource setting |
| title_fullStr | Development of an interview-based warfarin nomogram predicting the time spent in the therapeutic INR range: A cost-effective, and non-invasive strategy building from a cross sectional study in a low resource setting |
| title_full_unstemmed | Development of an interview-based warfarin nomogram predicting the time spent in the therapeutic INR range: A cost-effective, and non-invasive strategy building from a cross sectional study in a low resource setting |
| title_short | Development of an interview-based warfarin nomogram predicting the time spent in the therapeutic INR range: A cost-effective, and non-invasive strategy building from a cross sectional study in a low resource setting |
| title_sort | development of an interview based warfarin nomogram predicting the time spent in the therapeutic inr range a cost effective and non invasive strategy building from a cross sectional study in a low resource setting |
| topic | Warfarin nomogram Percent time in therapeutic range INR |
| url | http://www.sciencedirect.com/science/article/pii/S0019483222000529 |
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