Different antiviral effects of IFNα subtypes in a mouse model of HBV infection

Different antiviral effects of IFNα subtypes in a mouse model of HBV infection

Abstract Interferon alpha (IFNα) is commonly used for the treatment of chronic hepatitis B (CHB) patients. There are 13 different IFNα subtypes in humans, but only the subtype IFNα2 is used for clinical treatment. The antiviral activities of all other IFNα subtypes against HBV have not been studied....

Full description

Bibliographic Details
Main Authors:	Jingjiao Song, Sheng Li, Yun Zhou, Jia Liu, Sandra Francois, Mengji Lu, Dongliang Yang, Ulf Dittmer, Kathrin Sutter
Format:	Article
Language:	English
Published:	Nature Portfolio 2017-03-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-017-00469-1

Similar Items

IFNα subtype-specific susceptibility of HBV in the course of chronic infection
by: Xiaohong Xie, et al.
Published: (2022-10-01)

IFNα Subtypes in HIV Infection and Immunity
by: Zehra Karakoese, et al.
Published: (2024-02-01)

Targeted mutations in IFNα2 improve its antiviral activity against various viruses
by: Zehra Karakoese, et al.
Published: (2023-12-01)

Diverse Immunomodulatory Effects of Individual IFNα Subtypes on Virus-Specific CD8+ T Cell Responses
by: Julia Dickow, et al.
Published: (2019-09-01)

Qualitative Differences Between the IFNα subtypes and IFNβ Influence Chronic Mucosal HIV-1 Pathogenesis.
by: Kejun Guo, et al.
Published: (2020-10-01)

Antiviral potential of human IFN-α subtypes against influenza A H3N2 infection in human lung explants reveals subtype-specific activities
by: Aline da Rocha Matos, et al.
Published: (2019-01-01)

Susceptibility of different hepatitis B virus isolates to interferon-alpha in a mouse model based on hydrodynamic injection.
by: Jingjiao Song, et al.
Published: (2014-01-01)

Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral Infection
by: Mara Schwerdtfeger, et al.
Published: (2022-01-01)

DNA immunization with fusion of CTLA-4 to hepatitis B virus (HBV) core protein enhanced Th2 type responses and cleared HBV with an accelerated kinetic.
by: Ying Yin, et al.
Published: (2011-01-01)

Distinct Type I Interferon Subtypes Differentially Stimulate T Cell Responses in HIV-1-Infected Individuals
by: Zehra Karakoese, et al.
Published: (2022-07-01)

Superior antiviral activity of IFNβ in genital HSV-1 infection
by: Yasmin Schmitz, et al.
Published: (2022-10-01)

Antiviral Activity of Porcine IFN-λ3 and IFN-α against Porcine Rotavirus In Vitro
by: Lishuang Deng, et al.
Published: (2022-07-01)

HIV infection does not alter interferon α/β receptor 2 expression on mucosal immune cells.
by: Julia Ickler, et al.
Published: (2020-01-01)

HBV-miR-3 is closely related to HBV replication and strongly predictive of HBeAg seroconversion in PegIFN-α treated patients
by: Zhenyu Xu, et al.
Published: (2024-01-01)

Different Biological Activities of Specific Interferon Alpha Subtypes
by: Kim J. Hasenkrug, et al.
Published: (2019-08-01)

Diverse Anti-Tumor Immune Potential Driven by Individual IFNα Subtypes
by: Anthony C. Buzzai, et al.
Published: (2020-04-01)

Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells
by: Stephanie S. Pavlovich, et al.
Published: (2020-03-01)

Over-expression and single-step purification of human IFN<sub>α8 </sub>and human IFN<sub>α2b </sub>reveals the highest antiviral activity of human IFN<sub>α8</sub>
by: Perez Vladimir, et al.
Published: (2006-10-01)

Toll-like receptor-mediated innate immunity orchestrates adaptive immune responses in HBV infection
by: Yanqin Du, et al.
Published: (2022-07-01)

The Effect of ICOS Polymorphism Interactions with HBV Mutations on HBV Subtype Infection Outcomes
by: Xiao-Mei Song, et al.
Published: (2018-11-01)

PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response.
by: LanLan Liu, et al.
Published: (2020-01-01)

Interferon-Stimulated Gene 15 Knockout in Mice Impairs IFNα-Mediated Antiviral Activity
by: Chen Li, et al.
Published: (2022-08-01)

PreC and C Regions of Woodchuck Hepatitis Virus Facilitate Persistent Expression of Surface Antigen of Chimeric WHV-HBV Virus in the Hydrodynamic Injection BALB/c Mouse Model
by: Weimin Wu, et al.
Published: (2017-02-01)

Baicalin Induces IFN-α/β and IFN-γ Expressions in Cultured Mouse Pulmonary Microvascular Endothelial Cells
by: Ge HU, et al.
Published: (2012-04-01)

In-vivo Activity of IFN-λ and IFN-α Against Bovine-Viral-Diarrhea Virus in a Mouse Model
by: María Eugenia Quintana, et al.
Published: (2020-02-01)

IFN-I Independent Antiviral Immune Response to Vesicular Stomatitis Virus Challenge in Mouse Brain
by: Anurag R. Mishra, et al.
Published: (2020-06-01)

Immunosuppressive drugs modulate the replication of hepatitis B virus (HBV) in a hydrodynamic injection mouse model.
by: Junzhong Wang, et al.
Published: (2014-01-01)

The relation of polymorphisms in +874 region of IFN-Gama with occult HBV infection
by: Kazemi Arababadi M (PhD), et al.
Published: (2010-03-01)

Chicken DDX1 Acts as an RNA Sensor to Mediate IFN-β Signaling Pathway Activation in Antiviral Innate Immunity
by: Zhenyu Lin, et al.
Published: (2021-09-01)

The epidemiological changes of HCV and HBV infections in the era of new antiviral therapies and the anti-HBV vaccine
by: Cristina Stasi, et al.
Published: (2016-07-01)

Interferon-alpha subtype 11 activates NK cells and enables control of retroviral infection.
by: Kathrin Gibbert, et al.
Published: (2012-01-01)

Inhibition of the HCV core protein on the immune response to HBV surface antigen and on HBV gene expression and replication in vivo.
by: Wenbo Zhu, et al.
Published: (2012-01-01)

Characterization of the Treg Response in the Hepatitis B Virus Hydrodynamic Injection Mouse Model.
by: Kirsten K Dietze, et al.
Published: (2016-01-01)

Antiviral Therapy for Chronic HBV Infection With Persistently Normal Alanine Aminotransferase: Controversy and Consensus
by: Jing Zhou, et al.
Published: (2021-08-01)

Association of HBV DNA replication with antiviral treatment outcomes in the patients with early-stage HBV-related hepatocellular carcinoma undergoing curative resection
by: Jian-Lin Chen, et al.
Published: (2016-03-01)

Increased HBV Coinfection and Decreased IFN-γ-Producing HBV-Specific CD8+ T Cell Numbers During HIV Disease Progression
by: Zhiqiang Zhu, et al.
Published: (2022-03-01)

Persistence of the recombinant genomes of woodchuck hepatitis virus in the mouse model.
by: Danzhen Pan, et al.
Published: (2015-01-01)

Extrahepatic Manifestations of Chronic HBV Infection and the Role of Antiviral Therapy
by: Cesare Mazzaro, et al.
Published: (2022-10-01)

Editorial: Interferon and its antiviral effect in response to HBV infection
by: Hongxiao Song, et al.
Published: (2023-02-01)

Antiviral Treatment of Chronic Hepatitis B Virus (HBV) Infections
by: Erik De Clercq, et al.
Published: (2010-05-01)