Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation

Timing of in utero malaria exposure influences fetal CD4 T cell regulatory versus effector differentiation

Abstract Background In malaria-endemic areas, the first exposure to malaria antigens often occurs in utero when the fetal immune system is poised towards the development of tolerance. Children exposed to placental malaria have an increased risk of clinical malaria in the first few years of life comp...

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Bibliographic Details
Main Authors: Mary Prahl, Prasanna Jagannathan, Tara I. McIntyre, Ann Auma, Lila Farrington, Samuel Wamala, Mayimuna Nalubega, Kenneth Musinguzi, Kate Naluwu, Esther Sikyoma, Rachel Budker, Hilary Vance, Pamela Odorizzi, Patience Nayebare, John Ategeka, Abel Kakuru, Diane V. Havlir, Moses R. Kamya, Grant Dorsey, Margaret E. Feeney
Format: Article
Language:English
Published: BMC 2016-10-01
Series:Malaria Journal
Subjects:
Pregnancy-associated malaria
Fetal immune response
Immune tolerance
CD4 T cells
Dendritic cells
Loop-mediated isothermal amplification
Online Access:http://link.springer.com/article/10.1186/s12936-016-1545-6

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