Effect of intravenous lidocaine on postoperative atrial fibrillation, IL-6 and IL-10 in patients undergoing cardiac surgery
Objective To investigate the effect of intravenous lidocaine on postoperative atrial fibrillation, IL-6 and IL-10 levels in patients undergoing cardiac surgery. Methods Sixty patients scheduled for cardiac surgery requiring cardiopulmonary bypass, were randomly divided into two groups based on compu...
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| Format: | Article |
| Language: | zho |
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Editorial Office of Journal of New Medicine
2022-09-01
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| Series: | Xin yixue |
| Subjects: | |
| Online Access: | https://www.xinyixue.cn/fileup/0253-9802/PDF/1664415703941-306535349.pdf |
| _version_ | 1828722515301629952 |
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| author | Li Qiongzhen, Wu Dehua, Tan Gang, Wu Jingxiang, Xu Meiying |
| author_facet | Li Qiongzhen, Wu Dehua, Tan Gang, Wu Jingxiang, Xu Meiying |
| author_sort | Li Qiongzhen, Wu Dehua, Tan Gang, Wu Jingxiang, Xu Meiying |
| collection | DOAJ |
| description | Objective To investigate the effect of intravenous lidocaine on postoperative atrial fibrillation, IL-6 and IL-10 levels in patients undergoing cardiac surgery. Methods Sixty patients scheduled for cardiac surgery requiring cardiopulmonary bypass, were randomly divided into two groups based on computer-generated randomized assignments： lidocaine group （Group L, n = 30） and control group （Group C, n = 30）. Patients in Group L received three-phase intravenous lidocaine infusion regimen as follows： upon induction of general anesthesia, a bolus of intravenous lidocaine 1.5 mg/kg was given over a minimum of 5 min; subsequently, lidocaine 2.3 mg/（kg·h） was infused for the first 3 h; lidocaine was then reduced to 0.8 mg/（kg·h） and discontinued 24 h postoperatively. Patients in Group C received intravenous saline infusion. The bolus amounts and infusion rates were identical to those in Group L. Blood samples were collected before, at the end of surgery and 24 h after surgery for measurement of IL-6 and IL-10 levels. The episode of new onset of atrial fibrillation and the development of cardiovascular events after surgery were recorded. Results Compared with preoperative levels, serum IL-6 and IL-10 levels at the end of surgery and 24 h after surgery were significantly higher （all P < 0.01）. Compared with Group C, serum IL-6 and IL-10 levels at the end of surgery and 24 h after surgery were significantly lower in Group L （P < 0.05 or P < 0.01）. In Group C, postoperative extubation time was （15.9±3.6） h, significantly longer than （12.2±4.7） h in Group L （P < 0.01）. Compared with Group C, the incidence of postoperative atrial fibrillation tended to decline in Group L（10% vs. 24%, P > 0.05）. Conclusions Perioperative intravenous infusion of lidocaine could decrease postoperative serum IL-6 and IL-10 levels, shorten tracheal extubation time and lower the risk of postoperative atrial fibrillation. |
| first_indexed | 2024-04-12T05:40:41Z |
| format | Article |
| id | doaj.art-23185396fb95406b87b1e3a17cf30d66 |
| institution | Directory Open Access Journal |
| issn | 0253-9802 |
| language | zho |
| last_indexed | 2024-04-12T05:40:41Z |
| publishDate | 2022-09-01 |
| publisher | Editorial Office of Journal of New Medicine |
| record_format | Article |
| series | Xin yixue |
| spelling | doaj.art-23185396fb95406b87b1e3a17cf30d662022-12-22T03:45:38ZzhoEditorial Office of Journal of New MedicineXin yixue0253-98022022-09-0153966566910.3969/j.issn.0253-9802.2022.09.009Effect of intravenous lidocaine on postoperative atrial fibrillation, IL-6 and IL-10 in patients undergoing cardiac surgeryLi Qiongzhen, Wu Dehua, Tan Gang, Wu Jingxiang, Xu Meiying0△Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200032, ChinaObjective To investigate the effect of intravenous lidocaine on postoperative atrial fibrillation, IL-6 and IL-10 levels in patients undergoing cardiac surgery. Methods Sixty patients scheduled for cardiac surgery requiring cardiopulmonary bypass, were randomly divided into two groups based on computer-generated randomized assignments： lidocaine group （Group L, n = 30） and control group （Group C, n = 30）. Patients in Group L received three-phase intravenous lidocaine infusion regimen as follows： upon induction of general anesthesia, a bolus of intravenous lidocaine 1.5 mg/kg was given over a minimum of 5 min; subsequently, lidocaine 2.3 mg/（kg·h） was infused for the first 3 h; lidocaine was then reduced to 0.8 mg/（kg·h） and discontinued 24 h postoperatively. Patients in Group C received intravenous saline infusion. The bolus amounts and infusion rates were identical to those in Group L. Blood samples were collected before, at the end of surgery and 24 h after surgery for measurement of IL-6 and IL-10 levels. The episode of new onset of atrial fibrillation and the development of cardiovascular events after surgery were recorded. Results Compared with preoperative levels, serum IL-6 and IL-10 levels at the end of surgery and 24 h after surgery were significantly higher （all P < 0.01）. Compared with Group C, serum IL-6 and IL-10 levels at the end of surgery and 24 h after surgery were significantly lower in Group L （P < 0.05 or P < 0.01）. In Group C, postoperative extubation time was （15.9±3.6） h, significantly longer than （12.2±4.7） h in Group L （P < 0.01）. Compared with Group C, the incidence of postoperative atrial fibrillation tended to decline in Group L（10% vs. 24%, P > 0.05）. Conclusions Perioperative intravenous infusion of lidocaine could decrease postoperative serum IL-6 and IL-10 levels, shorten tracheal extubation time and lower the risk of postoperative atrial fibrillation.https://www.xinyixue.cn/fileup/0253-9802/PDF/1664415703941-306535349.pdf|lidocaine|cardiac surgery|cardiopulmonary bypass|atrial fibrillation|interleukin |
| spellingShingle | Li Qiongzhen, Wu Dehua, Tan Gang, Wu Jingxiang, Xu Meiying Effect of intravenous lidocaine on postoperative atrial fibrillation, IL-6 and IL-10 in patients undergoing cardiac surgery Xin yixue |lidocaine|cardiac surgery|cardiopulmonary bypass|atrial fibrillation|interleukin |
| title | Effect of intravenous lidocaine on postoperative atrial fibrillation, IL-6 and IL-10 in patients undergoing cardiac surgery |
| title_full | Effect of intravenous lidocaine on postoperative atrial fibrillation, IL-6 and IL-10 in patients undergoing cardiac surgery |
| title_fullStr | Effect of intravenous lidocaine on postoperative atrial fibrillation, IL-6 and IL-10 in patients undergoing cardiac surgery |
| title_full_unstemmed | Effect of intravenous lidocaine on postoperative atrial fibrillation, IL-6 and IL-10 in patients undergoing cardiac surgery |
| title_short | Effect of intravenous lidocaine on postoperative atrial fibrillation, IL-6 and IL-10 in patients undergoing cardiac surgery |
| title_sort | effect of intravenous lidocaine on postoperative atrial fibrillation il 6 and il 10 in patients undergoing cardiac surgery |
| topic | |lidocaine|cardiac surgery|cardiopulmonary bypass|atrial fibrillation|interleukin |
| url | https://www.xinyixue.cn/fileup/0253-9802/PDF/1664415703941-306535349.pdf |
| work_keys_str_mv | AT liqiongzhenwudehuatangangwujingxiangxumeiying effectofintravenouslidocaineonpostoperativeatrialfibrillationil6andil10inpatientsundergoingcardiacsurgery |