Seizure outcome-related factors in autoimmune encephalitis: A systematic review and meta-analysis
BackgroundIdentifying the predictors for seizure outcome in autoimmune encephalitis (AE) and investigating how to prevent persistent seizures would have major clinical benefits effectively. Thus, we aimed to perform a systematic review and meta-analysis to examine seizure outcome-related factors in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.991043/full |
| _version_ | 1828157119617040384 |
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| author | Peijuan Luo Rui Zhong Qingling Chen Weihong Lin |
| author_facet | Peijuan Luo Rui Zhong Qingling Chen Weihong Lin |
| author_sort | Peijuan Luo |
| collection | DOAJ |
| description | BackgroundIdentifying the predictors for seizure outcome in autoimmune encephalitis (AE) and investigating how to prevent persistent seizures would have major clinical benefits effectively. Thus, we aimed to perform a systematic review and meta-analysis to examine seizure outcome-related factors in AE patients.MethodsPubMed and EMBASE were systematically searched from inception to 10 June 2022 for studies investigating seizure outcome-related factors in AE. The pooled effect estimates, including standardized mean differences (SMDs) and odds ratios (ORs) with 95% confidence intervals (CIs), were calculated to estimate the effect of each included factor on the seizure outcome.ResultsA total of 10 studies were included in the meta-analysis. Our pooled results of this meta-analysis showed that five factors were found to increase the risk of persistent seizures in AE patients, including onset with seizures (OR = 2.106, 95% CI = 1.262–3.514, p = 0.004), status epilepticus (OR = 3.017, 95% CI = 1.995–4.563, p < 0.001), EEG abnormalities (OR = 1.581, 95% CI = 1.016–2.46, p = 0.042), MRI abnormalities (OR = 1.554, 95% CI = 1.044–2.283, p = 0.03), and longer time from clinical onset to immunotherapy (SMD = 1.887, 95% CI = 0.598–3.156, p = 0.004).ConclusionOur meta-analysis indicated that onset with seizures, status epilepticus, EEG abnormalities, MRI abnormalities, and longer time from clinical onset to immunotherapy were risk factors for persistent seizures in AE patients. |
| first_indexed | 2024-04-11T23:22:56Z |
| format | Article |
| id | doaj.art-23193c8b40684dedad854db580ece0a4 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-11T23:22:56Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-23193c8b40684dedad854db580ece0a42022-12-22T03:57:23ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-11-011310.3389/fneur.2022.991043991043Seizure outcome-related factors in autoimmune encephalitis: A systematic review and meta-analysisPeijuan Luo0Rui Zhong1Qingling Chen2Weihong Lin3Department of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaDepartment of Hepatology, Second People's Clinical College of Tianjin Medical University, Tianjin, ChinaDepartment of Neurology, The First Hospital of Jilin University, Changchun, ChinaBackgroundIdentifying the predictors for seizure outcome in autoimmune encephalitis (AE) and investigating how to prevent persistent seizures would have major clinical benefits effectively. Thus, we aimed to perform a systematic review and meta-analysis to examine seizure outcome-related factors in AE patients.MethodsPubMed and EMBASE were systematically searched from inception to 10 June 2022 for studies investigating seizure outcome-related factors in AE. The pooled effect estimates, including standardized mean differences (SMDs) and odds ratios (ORs) with 95% confidence intervals (CIs), were calculated to estimate the effect of each included factor on the seizure outcome.ResultsA total of 10 studies were included in the meta-analysis. Our pooled results of this meta-analysis showed that five factors were found to increase the risk of persistent seizures in AE patients, including onset with seizures (OR = 2.106, 95% CI = 1.262–3.514, p = 0.004), status epilepticus (OR = 3.017, 95% CI = 1.995–4.563, p < 0.001), EEG abnormalities (OR = 1.581, 95% CI = 1.016–2.46, p = 0.042), MRI abnormalities (OR = 1.554, 95% CI = 1.044–2.283, p = 0.03), and longer time from clinical onset to immunotherapy (SMD = 1.887, 95% CI = 0.598–3.156, p = 0.004).ConclusionOur meta-analysis indicated that onset with seizures, status epilepticus, EEG abnormalities, MRI abnormalities, and longer time from clinical onset to immunotherapy were risk factors for persistent seizures in AE patients.https://www.frontiersin.org/articles/10.3389/fneur.2022.991043/fullautoimmune encephalitisseizure outcomepersistent seizuresrisk factorsmeta-analysis |
| spellingShingle | Peijuan Luo Rui Zhong Qingling Chen Weihong Lin Seizure outcome-related factors in autoimmune encephalitis: A systematic review and meta-analysis Frontiers in Neurology autoimmune encephalitis seizure outcome persistent seizures risk factors meta-analysis |
| title | Seizure outcome-related factors in autoimmune encephalitis: A systematic review and meta-analysis |
| title_full | Seizure outcome-related factors in autoimmune encephalitis: A systematic review and meta-analysis |
| title_fullStr | Seizure outcome-related factors in autoimmune encephalitis: A systematic review and meta-analysis |
| title_full_unstemmed | Seizure outcome-related factors in autoimmune encephalitis: A systematic review and meta-analysis |
| title_short | Seizure outcome-related factors in autoimmune encephalitis: A systematic review and meta-analysis |
| title_sort | seizure outcome related factors in autoimmune encephalitis a systematic review and meta analysis |
| topic | autoimmune encephalitis seizure outcome persistent seizures risk factors meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.991043/full |
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