Fabry disease, do we think enough about this multisystemic disorder?: A presentation of three cases in a Serbian family
Background. Fabry Disease is a rare, X-chromosomal inherited lysosomal storage disease with a consequent intracellular accumulation of neutral glycosphingolipids in various tissues. This can cause skin and ocular lessions, progressive renal, cardiac or cerebrovascular disorders. If a person in a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Military Health Department, Ministry of Defance, Serbia
2012-01-01
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| Series: | Vojnosanitetski Pregled |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501207620S.pdf |
| _version_ | 1817970880136871936 |
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| author | Sakač Dejan Koraćević Goran Pavlica Tatjana Sekulić Slobodan |
| author_facet | Sakač Dejan Koraćević Goran Pavlica Tatjana Sekulić Slobodan |
| author_sort | Sakač Dejan |
| collection | DOAJ |
| description | Background. Fabry Disease is a rare, X-chromosomal inherited lysosomal storage disease with a consequent intracellular accumulation of neutral glycosphingolipids in various tissues. This can cause skin and ocular lessions, progressive renal, cardiac or cerebrovascular disorders. If a person in a family has Fabry disease, other family members including even extended relatives, may also be at risk. Case report. We presented three cases pointed out various manifestation of Fabry disease, that illustrate a possible cause for otherwise unexplained cardiac hypertrophy and various rhythm and conduction abnormalities. Conclusion. Although most symptoms begin in childhood, various manifestations often lead to misdiagnosis and clinical diagnosis is frequently delayed for many years, even decades. Enzyme replacement therapy has become available, pointing out the importance of early diagnosis so that treatment can be initiated before irreversible organ damage. |
| first_indexed | 2024-04-13T20:39:32Z |
| format | Article |
| id | doaj.art-2319623838804896af1b529e3411145c |
| institution | Directory Open Access Journal |
| issn | 0042-8450 |
| language | English |
| last_indexed | 2024-04-13T20:39:32Z |
| publishDate | 2012-01-01 |
| publisher | Military Health Department, Ministry of Defance, Serbia |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj.art-2319623838804896af1b529e3411145c2022-12-22T02:30:54ZengMilitary Health Department, Ministry of Defance, SerbiaVojnosanitetski Pregled0042-84502012-01-0169762062210.2298/VSP1207620SFabry disease, do we think enough about this multisystemic disorder?: A presentation of three cases in a Serbian familySakač DejanKoraćević GoranPavlica TatjanaSekulić SlobodanBackground. Fabry Disease is a rare, X-chromosomal inherited lysosomal storage disease with a consequent intracellular accumulation of neutral glycosphingolipids in various tissues. This can cause skin and ocular lessions, progressive renal, cardiac or cerebrovascular disorders. If a person in a family has Fabry disease, other family members including even extended relatives, may also be at risk. Case report. We presented three cases pointed out various manifestation of Fabry disease, that illustrate a possible cause for otherwise unexplained cardiac hypertrophy and various rhythm and conduction abnormalities. Conclusion. Although most symptoms begin in childhood, various manifestations often lead to misdiagnosis and clinical diagnosis is frequently delayed for many years, even decades. Enzyme replacement therapy has become available, pointing out the importance of early diagnosis so that treatment can be initiated before irreversible organ damage.http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501207620S.pdfFabry diseasechromosome aberrationsgenetic diseasesinborndiagnosis, differential |
| spellingShingle | Sakač Dejan Koraćević Goran Pavlica Tatjana Sekulić Slobodan Fabry disease, do we think enough about this multisystemic disorder?: A presentation of three cases in a Serbian family Vojnosanitetski Pregled Fabry disease chromosome aberrations genetic diseases inborn diagnosis, differential |
| title | Fabry disease, do we think enough about this multisystemic disorder?: A presentation of three cases in a Serbian family |
| title_full | Fabry disease, do we think enough about this multisystemic disorder?: A presentation of three cases in a Serbian family |
| title_fullStr | Fabry disease, do we think enough about this multisystemic disorder?: A presentation of three cases in a Serbian family |
| title_full_unstemmed | Fabry disease, do we think enough about this multisystemic disorder?: A presentation of three cases in a Serbian family |
| title_short | Fabry disease, do we think enough about this multisystemic disorder?: A presentation of three cases in a Serbian family |
| title_sort | fabry disease do we think enough about this multisystemic disorder a presentation of three cases in a serbian family |
| topic | Fabry disease chromosome aberrations genetic diseases inborn diagnosis, differential |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2012/0042-84501207620S.pdf |
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