Recent advances in the repair of degenerative intervertebral disc for preclinical applications
The intervertebral disc (IVD) is a load-bearing, avascular tissue that cushions pressure and increases flexibility in the spine. Under the influence of obesity, injury, and reduced nutrient supply, it develops pathological changes such as fibular annulus (AF) injury, disc herniation, and inflammatio...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1259731/full |
| _version_ | 1797676732802662400 |
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| author | Yijian Ying Kaiwen Cai Xiongxiong Cai Kai Zhang Rongzhang Qiu Guoqiang Jiang Kefeng Luo |
| author_facet | Yijian Ying Kaiwen Cai Xiongxiong Cai Kai Zhang Rongzhang Qiu Guoqiang Jiang Kefeng Luo |
| author_sort | Yijian Ying |
| collection | DOAJ |
| description | The intervertebral disc (IVD) is a load-bearing, avascular tissue that cushions pressure and increases flexibility in the spine. Under the influence of obesity, injury, and reduced nutrient supply, it develops pathological changes such as fibular annulus (AF) injury, disc herniation, and inflammation, eventually leading to intervertebral disc degeneration (IDD). Lower back pain (LBP) caused by IDD is a severe chronic disorder that severely affects patients’ quality of life and has a substantial socioeconomic impact. Patients may consider surgical treatment after conservative treatment has failed. However, the broken AF cannot be repaired after surgery, and the incidence of re-protrusion and reoccurring pain is high, possibly leading to a degeneration of the adjacent vertebrae. Therefore, effective treatment strategies must be explored to repair and prevent IDD. This paper systematically reviews recent advances in repairing IVD, describes its advantages and shortcomings, and explores the future direction of repair technology. |
| first_indexed | 2024-03-11T22:34:36Z |
| format | Article |
| id | doaj.art-231a13ab2ead4bd794a46541e45a0cff |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-03-11T22:34:36Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-231a13ab2ead4bd794a46541e45a0cff2023-09-22T17:49:57ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852023-09-011110.3389/fbioe.2023.12597311259731Recent advances in the repair of degenerative intervertebral disc for preclinical applicationsYijian Ying0Kaiwen Cai1Xiongxiong Cai2Kai Zhang3Rongzhang Qiu4Guoqiang Jiang5Kefeng Luo6Health Science Center, Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaHealth Science Center, Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaHealth Science Center, Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaDepartment of Orthopaedics, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, ChinaThe intervertebral disc (IVD) is a load-bearing, avascular tissue that cushions pressure and increases flexibility in the spine. Under the influence of obesity, injury, and reduced nutrient supply, it develops pathological changes such as fibular annulus (AF) injury, disc herniation, and inflammation, eventually leading to intervertebral disc degeneration (IDD). Lower back pain (LBP) caused by IDD is a severe chronic disorder that severely affects patients’ quality of life and has a substantial socioeconomic impact. Patients may consider surgical treatment after conservative treatment has failed. However, the broken AF cannot be repaired after surgery, and the incidence of re-protrusion and reoccurring pain is high, possibly leading to a degeneration of the adjacent vertebrae. Therefore, effective treatment strategies must be explored to repair and prevent IDD. This paper systematically reviews recent advances in repairing IVD, describes its advantages and shortcomings, and explores the future direction of repair technology.https://www.frontiersin.org/articles/10.3389/fbioe.2023.1259731/fullintervertebral discfibrous annulusdegenerationrepairtissue engineeringbiomaterials |
| spellingShingle | Yijian Ying Kaiwen Cai Xiongxiong Cai Kai Zhang Rongzhang Qiu Guoqiang Jiang Kefeng Luo Recent advances in the repair of degenerative intervertebral disc for preclinical applications Frontiers in Bioengineering and Biotechnology intervertebral disc fibrous annulus degeneration repair tissue engineering biomaterials |
| title | Recent advances in the repair of degenerative intervertebral disc for preclinical applications |
| title_full | Recent advances in the repair of degenerative intervertebral disc for preclinical applications |
| title_fullStr | Recent advances in the repair of degenerative intervertebral disc for preclinical applications |
| title_full_unstemmed | Recent advances in the repair of degenerative intervertebral disc for preclinical applications |
| title_short | Recent advances in the repair of degenerative intervertebral disc for preclinical applications |
| title_sort | recent advances in the repair of degenerative intervertebral disc for preclinical applications |
| topic | intervertebral disc fibrous annulus degeneration repair tissue engineering biomaterials |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2023.1259731/full |
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