Homocysteine levels and platelet aggregation in patients with cerebral circulatory disorders

AIM: To reveal platelet functional changes manifesting as abnormal rate of platelet aggregation in patients with acute cerebral circulatory disorders (ischemic stroke, transient ischemic attack), to evaluate the effect of homocysteine (Hc) on platelet aggregation, depending on the degree of cerebral...

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Main Authors: Z Sabaliauskiene, P Gribauskas, V Gaigalaite, J Ptašekas, V Ojeraitene, D Kalibatene
Format: Article
Language:Russian
Published: "Consilium Medicum" Publishing house 2013-03-01
Series:Терапевтический архив
Subjects:
Online Access:https://ter-arkhiv.ru/0040-3660/article/view/31239
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author Z Sabaliauskiene
P Gribauskas
V Gaigalaite
J Ptašekas
V Ojeraitene
D Kalibatene
author_facet Z Sabaliauskiene
P Gribauskas
V Gaigalaite
J Ptašekas
V Ojeraitene
D Kalibatene
author_sort Z Sabaliauskiene
collection DOAJ
description AIM: To reveal platelet functional changes manifesting as abnormal rate of platelet aggregation in patients with acute cerebral circulatory disorders (ischemic stroke, transient ischemic attack), to evaluate the effect of homocysteine (Hc) on platelet aggregation, depending on the degree of cerebral blood flow disturbances, patients' gender and age, and to estimate the diagnostic value of their associations/MATERIAL AND METHODS: 50 patients aged 33 to 98 years (mean age, 63.7±2.1 years; 20 men and 30 women) with acute cerebral circulatory disorders (18 with transient ischemic attack and 32 with ischemic stroke) were examined. The diagnosis was verified by the results of computed tomography and other clinical examinations. Adenosine diphosphate-, epinephrine-, and collagen-induced platelet aggregation was assessed in platelet-rich plasma; serum Hc concentrations were also studied/RESULTS: Comparison of platelet aggregation and Hc concentration revealed a statistically significant correlation between platelet aggregation with collagen and elevated Hc levels (r=0.376; p0.05). The levels of Hc were statistically significantly higher as cerebral circulatory disorders progressed/CONCLUSION: There was a statistically significantly relationship between collagen-induced platelet aggregation and Hc concentration. The Hc levels were statistically significantly related to the severity of cerebral circulatory disorders and age.
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spelling doaj.art-231b35cba2e74e10a9f5cc8673f3ffb32022-12-22T00:28:18Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422013-03-01853757928255Homocysteine levels and platelet aggregation in patients with cerebral circulatory disordersZ SabaliauskieneP GribauskasV GaigalaiteJ PtašekasV OjeraiteneD KalibateneAIM: To reveal platelet functional changes manifesting as abnormal rate of platelet aggregation in patients with acute cerebral circulatory disorders (ischemic stroke, transient ischemic attack), to evaluate the effect of homocysteine (Hc) on platelet aggregation, depending on the degree of cerebral blood flow disturbances, patients' gender and age, and to estimate the diagnostic value of their associations/MATERIAL AND METHODS: 50 patients aged 33 to 98 years (mean age, 63.7±2.1 years; 20 men and 30 women) with acute cerebral circulatory disorders (18 with transient ischemic attack and 32 with ischemic stroke) were examined. The diagnosis was verified by the results of computed tomography and other clinical examinations. Adenosine diphosphate-, epinephrine-, and collagen-induced platelet aggregation was assessed in platelet-rich plasma; serum Hc concentrations were also studied/RESULTS: Comparison of platelet aggregation and Hc concentration revealed a statistically significant correlation between platelet aggregation with collagen and elevated Hc levels (r=0.376; p0.05). The levels of Hc were statistically significantly higher as cerebral circulatory disorders progressed/CONCLUSION: There was a statistically significantly relationship between collagen-induced platelet aggregation and Hc concentration. The Hc levels were statistically significantly related to the severity of cerebral circulatory disorders and age.https://ter-arkhiv.ru/0040-3660/article/view/31239homocysteineplatelet aggregationstroke
spellingShingle Z Sabaliauskiene
P Gribauskas
V Gaigalaite
J Ptašekas
V Ojeraitene
D Kalibatene
Homocysteine levels and platelet aggregation in patients with cerebral circulatory disorders
Терапевтический архив
homocysteine
platelet aggregation
stroke
title Homocysteine levels and platelet aggregation in patients with cerebral circulatory disorders
title_full Homocysteine levels and platelet aggregation in patients with cerebral circulatory disorders
title_fullStr Homocysteine levels and platelet aggregation in patients with cerebral circulatory disorders
title_full_unstemmed Homocysteine levels and platelet aggregation in patients with cerebral circulatory disorders
title_short Homocysteine levels and platelet aggregation in patients with cerebral circulatory disorders
title_sort homocysteine levels and platelet aggregation in patients with cerebral circulatory disorders
topic homocysteine
platelet aggregation
stroke
url https://ter-arkhiv.ru/0040-3660/article/view/31239
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AT vgaigalaite homocysteinelevelsandplateletaggregationinpatientswithcerebralcirculatorydisorders
AT jptasekas homocysteinelevelsandplateletaggregationinpatientswithcerebralcirculatorydisorders
AT vojeraitene homocysteinelevelsandplateletaggregationinpatientswithcerebralcirculatorydisorders
AT dkalibatene homocysteinelevelsandplateletaggregationinpatientswithcerebralcirculatorydisorders