Immunopathogenesis of Hepatitis B Infections
Hepatitis B virus (HBV) infections are among the major health problems and leading causes of cirrhosis and hepatocellular carcinoma worldwide. Despite therapeutic advancements, chronic HBV infection is not a curable disease yet. The clinical outcome of hepatitis B infections depend upon the age at i...
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| Format: | Article |
| Language: | English |
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Bilimsel Tip Yayinevi
2019-03-01
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| Series: | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
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| Online Access: | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2019-24-01-001-010.pdf |
| _version_ | 1797919148720783360 |
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| author | Necla Tülek |
| author_facet | Necla Tülek |
| author_sort | Necla Tülek |
| collection | DOAJ |
| description | Hepatitis B virus (HBV) infections are among the major health problems and leading causes of cirrhosis and hepatocellular carcinoma worldwide. Despite therapeutic advancements, chronic HBV infection is not a curable disease yet. The clinical outcome of hepatitis B infections depend upon the age at infection, level of HBV replication, and immune status of the host. While clinical course of the diseases ranges from subclinical hepatitis to anicteric hepatitis, icteric hepatitis, and fulminant hepatitis in acute hepatitis, manifestations range from an asymptomatic inactive state to chronic hepatitis, cirrhosis, and hepatocellular carcinoma in the chronic phase. Hepatitis B virus replicates in the hepatocyte non-cytopathically and most of the clinical syndromes associated with this infection due to immune response. Activation of the immune responses against viral infections is associated with both liver damage and virus elimination. Even though cellular immune response, especially the virus-specific effector CD8+ T cells, are central, several other components of the immune system components contribute to hepatitis B pathogenesis. In patients with chronic hepatitis B, both innate and adaptive immune responses are weak and T cell response is exhausted. Further understanding of the mechanisms of immunopathology would be beneficial in the development of new effective therapeutic strategies |
| first_indexed | 2024-04-10T13:40:59Z |
| format | Article |
| id | doaj.art-231bb575e93e4fddbc077a7e4f242909 |
| institution | Directory Open Access Journal |
| issn | 1300-932X 1300-932X |
| language | English |
| last_indexed | 2024-04-10T13:40:59Z |
| publishDate | 2019-03-01 |
| publisher | Bilimsel Tip Yayinevi |
| record_format | Article |
| series | Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi |
| spelling | doaj.art-231bb575e93e4fddbc077a7e4f2429092023-02-15T16:11:10ZengBilimsel Tip YayineviFlora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi1300-932X1300-932X2019-03-0124111010.5578/flora.68087Immunopathogenesis of Hepatitis B InfectionsNecla Tülek0Department of Medical Microbiology, Faculty of Medicine, University of Atılım, Ankara, TurkeyHepatitis B virus (HBV) infections are among the major health problems and leading causes of cirrhosis and hepatocellular carcinoma worldwide. Despite therapeutic advancements, chronic HBV infection is not a curable disease yet. The clinical outcome of hepatitis B infections depend upon the age at infection, level of HBV replication, and immune status of the host. While clinical course of the diseases ranges from subclinical hepatitis to anicteric hepatitis, icteric hepatitis, and fulminant hepatitis in acute hepatitis, manifestations range from an asymptomatic inactive state to chronic hepatitis, cirrhosis, and hepatocellular carcinoma in the chronic phase. Hepatitis B virus replicates in the hepatocyte non-cytopathically and most of the clinical syndromes associated with this infection due to immune response. Activation of the immune responses against viral infections is associated with both liver damage and virus elimination. Even though cellular immune response, especially the virus-specific effector CD8+ T cells, are central, several other components of the immune system components contribute to hepatitis B pathogenesis. In patients with chronic hepatitis B, both innate and adaptive immune responses are weak and T cell response is exhausted. Further understanding of the mechanisms of immunopathology would be beneficial in the development of new effective therapeutic strategieshttp://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2019-24-01-001-010.pdfHepatitis B virusInnate immunityAdaptive immunityPathogenesis |
| spellingShingle | Necla Tülek Immunopathogenesis of Hepatitis B Infections Flora Infeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi Hepatitis B virus Innate immunity Adaptive immunity Pathogenesis |
| title | Immunopathogenesis of Hepatitis B Infections |
| title_full | Immunopathogenesis of Hepatitis B Infections |
| title_fullStr | Immunopathogenesis of Hepatitis B Infections |
| title_full_unstemmed | Immunopathogenesis of Hepatitis B Infections |
| title_short | Immunopathogenesis of Hepatitis B Infections |
| title_sort | immunopathogenesis of hepatitis b infections |
| topic | Hepatitis B virus Innate immunity Adaptive immunity Pathogenesis |
| url | http://www.floradergisi.org/getFileContent.aspx?op=REDPDF&file_name=2019-24-01-001-010.pdf |
| work_keys_str_mv | AT neclatulek immunopathogenesisofhepatitisbinfections |