Nanobody-based CAR T cells targeting intracellular tumor antigens

Nanobody-based CAR T cells targeting intracellular tumor antigens

Chimeric antigen receptor (CAR) T-cell immunotherapy has become one of the research hotspots in the treatment of malignant tumors nowadays. However, the available tumor surface antigens are limited in number. Most tumor-associated antigens are intracellular molecules that can’t be targeted by conven...

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Bibliographic Details
Main Authors: Haixia Li, Dani Zhong, Huiguan Luo, Wei Shi, Shenxia Xie, Hangbiao Qiang, Lichen Zhu, Li Gao, Jun Liu, Shuyang Sun, Ziqiang Ding, Xiaomei Yang, Xiaoling Lu
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
CAR T-cell therapy
Nanobody
TCR-like antibody
Intracellular tumor antigen
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222013087

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