Molecular Basis of S100A1 Activation and Target Regulation Within Physiological Cytosolic Ca2+ Levels

Molecular Basis of S100A1 Activation and Target Regulation Within Physiological Cytosolic Ca2+ Levels

The S100A1 protein regulates cardiomyocyte function through its binding of calcium (Ca2+) and target proteins, including titin, SERCA, and RyR. S100A1 presents two Ca2+ binding domains, a high-affinity canonical EF-hand (cEF) and a low-affinity pseudo EF-hand (pEF), that control S100A1 activation. F...

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Bibliographic Details
Main Authors: Bin Sun, Peter M. Kekenes-Huskey
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
S100A1 protein
calcium affinity
post-translational modification (PTM)
passive tension
molecular dynamics
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2020.00077/full

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