Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice.

Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice.

Rift Valley fever (RVF) in humans is usually mild, but, in a subset of cases, can progress to severe hepatic and neurological disease. Rodent models of RVF generally develop acute severe clinical disease. Here, we inoculated humanized NSG-SGM3 mice with Rift Valley fever virus (RVFV) to investigate...

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Bibliographic Details
Main Authors: Jessica R Spengler, Anita K McElroy, Jessica R Harmon, JoAnn D Coleman-McCray, Stephen R Welch, James G Keck, Stuart T Nichol, Christina F Spiropoulou
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6054394?pdf=render

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