Noggin depletion in adipocytes promotes obesity in mice

Noggin depletion in adipocytes promotes obesity in mice

Objective: Obesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin is largely unknown. The aim of the study was...

Full description

Bibliographic Details
Main Authors:	Ana M. Blázquez-Medela, Medet Jumabay, Prashant Rajbhandari, Tamer Sallam, Yina Guo, Jiayi Yao, Laurent Vergnes, Karen Reue, Li Zhang, Yucheng Yao, Alan M. Fogelman, Peter Tontonoz, Aldons J. Lusis, Xiuju Wu, Kristina I. Boström
Format:	Article
Language:	English
Published:	Elsevier 2019-07-01
Series:	Molecular Metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2212877818311888

Similar Items

ABCC6 deficiency is associated with activation of BMP signaling in liver and kidney
by: Ana M. Blazquez-Medela, et al.
Published: (2015-01-01)

PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity
by: Diana M. Shih, et al.
Published: (2019-01-01)

Progenitor cells from brown adipose tissue undergo neurogenic differentiation
by: Medet Jumabay, et al.
Published: (2022-04-01)

Single cell analysis reveals immune cell–adipocyte crosstalk regulating the transcription of thermogenic adipocytes
by: Prashant Rajbhandari, et al.
Published: (2019-10-01)

Endothelial-Mesenchymal Transition in Vascular Calcification of Ins2Akita/+ Mice.
by: Pierre J Guihard, et al.
Published: (2016-01-01)

Noggin as a regulator of bone remodelling
by: Fatemeh Safari, et al.
Published: (2020-10-01)

Neuroprotective role of Noggin in spinal cord injury
by: Nadia Al-Sammarraie, et al.
Published: (2023-01-01)

Assessment of noggin level in pulmonary arterial hypertension patients
by: Al-Khafaji Khama’al Hussein Abod, et al.
Published: (2018-09-01)

The role of Wnt and Shh signaling systems in noggin-induced tumorigenesis
by: Andrei N. Mardaryev, et al.
Published: (2024-03-01)

Noggin contributes to brain metastatic colonization of lung cancer cells
by: Jung Eun Lee, et al.
Published: (2023-11-01)

Efficient in vitro delivery of Noggin siRNA enhances osteoblastogenesis
by: S. Ghadakzadeh, et al.
Published: (2017-11-01)

Targeted deletion of Tcf7l2 in adipocytes promotes adipocyte hypertrophy and impaired glucose metabolism
by: Gisela Geoghegan, et al.
Published: (2019-06-01)

COVID-19 Infection May Drive EC-like Myofibroblasts towards Myofibroblasts to Contribute to Pulmonary Fibrosis
by: Xiuju Wu, et al.
Published: (2023-07-01)

Contributions of the Endothelium to Vascular Calcification
by: Li Zhang, et al.
Published: (2021-05-01)

Loss of noggin1, a classic embryonic inducer gene, in elasmobranchs
by: Galina V. Ermakova, et al.
Published: (2024-02-01)

Prognostic value of noggin protein expression in patients with resected gastric cancer
by: Sang Hoon Chun, et al.
Published: (2021-05-01)

Thematic review series: Systems Biology Approaches to Metabolic and Cardiovascular Disorders Approaches to lipid metabolism gene identification and characterization in the postgenomic era
by: Karen Reue, et al.
Published: (2006-09-01)

Novel pathway of adipogenesis through cross-talk between adipose tissue macrophages, adipose stem cells and adipocytes: evidence of cell plasticity.
by: Gregorio Chazenbalk, et al.
Published: (2011-03-01)

SOX Transcription Factors in Endothelial Differentiation and Endothelial-Mesenchymal Transitions
by: Yucheng Yao, et al.
Published: (2019-03-01)

Differences in enteric neuronal density in the NSE-Noggin mouse model across institutes
by: Simone L. Schonkeren, et al.
Published: (2024-02-01)

A mathematical model of Noggin and BMP densities in adult neural stem cells
by: Kamila Larripa, et al.
Published: (2017-01-01)

Follistatin promotes adipocyte differentiation, browning, and energy metabolism[S]
by: Melissa Braga, et al.
Published: (2014-03-01)

A thematic review series: systems biology approaches to metabolic and cardiovascular disorders
by: Aldons J. Lusis
Published: (2006-09-01)

Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases.
by: Schwaninger, R, et al.
Published: (2007)

The role of the BMP signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasis.
by: Chiara Secondini, et al.
Published: (2011-01-01)

Enhanced osteogenesis of adipose derived stem cells with Noggin suppression and delivery of BMP-2.
by: Jiabing Fan, et al.
Published: (2013-01-01)

Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN.
by: Petra Seemann, et al.
Published: (2009-11-01)

Noggin Nodding: Head Movement Correlates With Increased Effort in Accelerating Speech Production Tasks
by: Mark Tiede, et al.
Published: (2019-11-01)

Transgenic tomatoes expressing the 6F peptide and ezetimibe prevent diet-induced increases of IFN-β and cholesterol 25-hydroxylase in jejunum
by: Pallavi Mukherjee, et al.
Published: (2017-08-01)

Crosstalk between BMP and Notch Induces Sox2 in Cerebral Endothelial Cells
by: Xiuju Wu, et al.
Published: (2019-06-01)

Shifting osteogenesis in vascular calcification
by: Jiayi Yao, et al.
Published: (2021-05-01)

NOTUM promotes thermogenic capacity and protects against diet-induced obesity in male mice
by: Fangfei Guo, et al.
Published: (2021-08-01)

Ectopic Noggin in a Population of Nfatc1 Lineage Endocardial Progenitors Induces Embryonic Lethality
by: Paige Snider, et al.
Published: (2014-11-01)

The bone morphogenetic protein antagonist noggin protects white matter after perinatal hypoxia–ischemia
by: Maria L.V. Dizon, et al.
Published: (2011-06-01)

Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance.
by: Julia Zimmer, et al.
Published: (2012-01-01)

Two-step regulation by matrix Gla protein in brown adipose cell differentiation
by: Li Zhang, et al.
Published: (2024-02-01)

Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP
by: Li Zhang, et al.
Published: (2017-10-01)

Preconditioning of Human Mesenchymal Stem Cells to Enhance Their Regulation of the Immune Response
by: Saparov, Arman, et al.
Published: (2017)

HRASLS3 is a PPARγ-selective target gene that promotes adipocyte differentiation*
by: Sarah Hummasti, et al.
Published: (2008-12-01)

Intrathecal Noggin administration in rats temporally ameliorates mechanical allodynia induced by a chronic constriction injury
by: Masayuki Hashimoto, et al.
Published: (2016-09-01)