Non-invasive brain stimulation and computational models in post-stroke aphasic patients: single session of transcranial magnetic stimulation and transcranial direct current stimulation. A randomized clinical trial
ABSTRACT CONTEXT AND OBJECTIVE: Patients undergoing the same neuromodulation protocol may present different responses. Computational models may help in understanding such differences. The aims of this study were, firstly, to compare the performance of aphasic patients in naming tasks before and aft...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Paulista de Medicina
2017-11-01
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| Series: | São Paulo Medical Journal |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017005015102&lng=en&tlng=en |
| _version_ | 1819243276192972800 |
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| author | Michele Devido dos Santos Vitor Breseghello Cavenaghi Ana Paula Machado Goyano Mac-Kay Vitor Serafim Alexandre Venturi Dennis Quangvinh Truong Yu Huang Paulo Sérgio Boggio Felipe Fregni Marcel Simis Marom Bikson Rubens José Gagliardi |
| author_facet | Michele Devido dos Santos Vitor Breseghello Cavenaghi Ana Paula Machado Goyano Mac-Kay Vitor Serafim Alexandre Venturi Dennis Quangvinh Truong Yu Huang Paulo Sérgio Boggio Felipe Fregni Marcel Simis Marom Bikson Rubens José Gagliardi |
| author_sort | Michele Devido dos Santos |
| collection | DOAJ |
| description | ABSTRACT CONTEXT AND OBJECTIVE: Patients undergoing the same neuromodulation protocol may present different responses. Computational models may help in understanding such differences. The aims of this study were, firstly, to compare the performance of aphasic patients in naming tasks before and after one session of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and sham, and analyze the results between these neuromodulation techniques; and secondly, through computational model on the cortex and surrounding tissues, to assess current flow distribution and responses among patients who received tDCS and presented different levels of results from naming tasks. DESIGN AND SETTING: Prospective, descriptive, qualitative and quantitative, double blind, randomized and placebo-controlled study conducted at Faculdade de Ciências Médicas da Santa Casa de São Paulo. METHODS: Patients with aphasia received one session of tDCS, TMS or sham stimulation. The time taken to name pictures and the response time were evaluated before and after neuromodulation. Selected patients from the first intervention underwent a computational model stimulation procedure that simulated tDCS. RESULTS: The results did not indicate any statistically significant differences from before to after the stimulation.The computational models showed different current flow distributions. CONCLUSIONS: The present study did not show any statistically significant difference between tDCS, TMS and sham stimulation regarding naming tasks. The patients’responses to the computational model showed different patterns of current distribution. |
| first_indexed | 2024-12-23T14:53:07Z |
| format | Article |
| id | doaj.art-232a34488e4a4ee2b57feb8300790699 |
| institution | Directory Open Access Journal |
| issn | 1806-9460 |
| language | English |
| last_indexed | 2024-12-23T14:53:07Z |
| publishDate | 2017-11-01 |
| publisher | Associação Paulista de Medicina |
| record_format | Article |
| series | São Paulo Medical Journal |
| spelling | doaj.art-232a34488e4a4ee2b57feb83007906992022-12-21T17:42:52ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-94602017-11-01010.1590/1516-3180.2016.0194060617S1516-31802017005015102Non-invasive brain stimulation and computational models in post-stroke aphasic patients: single session of transcranial magnetic stimulation and transcranial direct current stimulation. A randomized clinical trialMichele Devido dos SantosVitor Breseghello CavenaghiAna Paula Machado Goyano Mac-KayVitor SerafimAlexandre VenturiDennis Quangvinh TruongYu HuangPaulo Sérgio BoggioFelipe FregniMarcel SimisMarom BiksonRubens José GagliardiABSTRACT CONTEXT AND OBJECTIVE: Patients undergoing the same neuromodulation protocol may present different responses. Computational models may help in understanding such differences. The aims of this study were, firstly, to compare the performance of aphasic patients in naming tasks before and after one session of transcranial direct current stimulation (tDCS), transcranial magnetic stimulation (TMS) and sham, and analyze the results between these neuromodulation techniques; and secondly, through computational model on the cortex and surrounding tissues, to assess current flow distribution and responses among patients who received tDCS and presented different levels of results from naming tasks. DESIGN AND SETTING: Prospective, descriptive, qualitative and quantitative, double blind, randomized and placebo-controlled study conducted at Faculdade de Ciências Médicas da Santa Casa de São Paulo. METHODS: Patients with aphasia received one session of tDCS, TMS or sham stimulation. The time taken to name pictures and the response time were evaluated before and after neuromodulation. Selected patients from the first intervention underwent a computational model stimulation procedure that simulated tDCS. RESULTS: The results did not indicate any statistically significant differences from before to after the stimulation.The computational models showed different current flow distributions. CONCLUSIONS: The present study did not show any statistically significant difference between tDCS, TMS and sham stimulation regarding naming tasks. The patients’responses to the computational model showed different patterns of current distribution.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017005015102&lng=en&tlng=enAphasiaStrokeSpeech disordersTranscranial direct current stimulationTranscranial magnetic stimulation |
| spellingShingle | Michele Devido dos Santos Vitor Breseghello Cavenaghi Ana Paula Machado Goyano Mac-Kay Vitor Serafim Alexandre Venturi Dennis Quangvinh Truong Yu Huang Paulo Sérgio Boggio Felipe Fregni Marcel Simis Marom Bikson Rubens José Gagliardi Non-invasive brain stimulation and computational models in post-stroke aphasic patients: single session of transcranial magnetic stimulation and transcranial direct current stimulation. A randomized clinical trial São Paulo Medical Journal Aphasia Stroke Speech disorders Transcranial direct current stimulation Transcranial magnetic stimulation |
| title | Non-invasive brain stimulation and computational models in post-stroke aphasic patients: single session of transcranial magnetic stimulation and transcranial direct current stimulation. A randomized clinical trial |
| title_full | Non-invasive brain stimulation and computational models in post-stroke aphasic patients: single session of transcranial magnetic stimulation and transcranial direct current stimulation. A randomized clinical trial |
| title_fullStr | Non-invasive brain stimulation and computational models in post-stroke aphasic patients: single session of transcranial magnetic stimulation and transcranial direct current stimulation. A randomized clinical trial |
| title_full_unstemmed | Non-invasive brain stimulation and computational models in post-stroke aphasic patients: single session of transcranial magnetic stimulation and transcranial direct current stimulation. A randomized clinical trial |
| title_short | Non-invasive brain stimulation and computational models in post-stroke aphasic patients: single session of transcranial magnetic stimulation and transcranial direct current stimulation. A randomized clinical trial |
| title_sort | non invasive brain stimulation and computational models in post stroke aphasic patients single session of transcranial magnetic stimulation and transcranial direct current stimulation a randomized clinical trial |
| topic | Aphasia Stroke Speech disorders Transcranial direct current stimulation Transcranial magnetic stimulation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802017005015102&lng=en&tlng=en |
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