Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings
Aim: investigate the possible anti-psoriatic effect of ivermectin in mice based on observational and histopathological outcomes and biomarkers. Methods: Sixty male Swiss Albino Mice were divided into six groups (Groups I–VI); each group contained ten mice with shaved dorsal skin. The clini...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Pensoft Publishers
2024-02-01
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| Series: | Pharmacia |
| Online Access: | https://pharmacia.pensoft.net/article/114753/download/pdf/ |
| _version_ | 1797300138851434496 |
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| author | Sally Ayad Almudaris Fouad Kadhim Gatea |
| author_facet | Sally Ayad Almudaris Fouad Kadhim Gatea |
| author_sort | Sally Ayad Almudaris |
| collection | DOAJ |
| description | Aim: investigate the possible anti-psoriatic effect of ivermectin in mice based on observational and histopathological outcomes and biomarkers. Methods: Sixty male Swiss Albino Mice were divided into six groups (Groups I–VI); each group contained ten mice with shaved dorsal skin. The clinical, pathological, and laboratory effects were measured. Results: Topical Ivermectin significantly decreased vascular endothelial growth factor levels. At the same time, the combination of ivermectin plus Clobetasol showed a more significant reduction in tumor necrosis factor-alpha (TNF-α) and Interleukin-17 (IL-17) levels. Regarding the Interleukin-10 (IL-10) level, the Ivermectin and Ivermectin/Clobetasol combination groups showed a significant increase in IL-10. Conclusion: Topical Ivermectin’s anti-psoriasis activity increases IL-10 levels and could be used efficiently to alleviate psoriatic symptoms. Its combination treatment with Clobetasol holds promise for the management of psoriasis. |
| first_indexed | 2024-03-07T23:02:55Z |
| format | Article |
| id | doaj.art-232a3efa3af846d19fa5ccbb72b276f8 |
| institution | Directory Open Access Journal |
| issn | 2603-557X |
| language | English |
| last_indexed | 2024-03-07T23:02:55Z |
| publishDate | 2024-02-01 |
| publisher | Pensoft Publishers |
| record_format | Article |
| series | Pharmacia |
| spelling | doaj.art-232a3efa3af846d19fa5ccbb72b276f82024-02-22T10:40:59ZengPensoft PublishersPharmacia2603-557X2024-02-017111410.3897/pharmacia.71.e114753114753Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findingsSally Ayad Almudaris0Fouad Kadhim Gatea1Al-Nahrain UniversityAl-Nahrain UniversityAim: investigate the possible anti-psoriatic effect of ivermectin in mice based on observational and histopathological outcomes and biomarkers. Methods: Sixty male Swiss Albino Mice were divided into six groups (Groups I–VI); each group contained ten mice with shaved dorsal skin. The clinical, pathological, and laboratory effects were measured. Results: Topical Ivermectin significantly decreased vascular endothelial growth factor levels. At the same time, the combination of ivermectin plus Clobetasol showed a more significant reduction in tumor necrosis factor-alpha (TNF-α) and Interleukin-17 (IL-17) levels. Regarding the Interleukin-10 (IL-10) level, the Ivermectin and Ivermectin/Clobetasol combination groups showed a significant increase in IL-10. Conclusion: Topical Ivermectin’s anti-psoriasis activity increases IL-10 levels and could be used efficiently to alleviate psoriatic symptoms. Its combination treatment with Clobetasol holds promise for the management of psoriasis.https://pharmacia.pensoft.net/article/114753/download/pdf/ |
| spellingShingle | Sally Ayad Almudaris Fouad Kadhim Gatea Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings Pharmacia |
| title | Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings |
| title_full | Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings |
| title_fullStr | Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings |
| title_full_unstemmed | Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings |
| title_short | Effects of topical Ivermectin on imiquimod-induced Psoriasis in mouse model – Novel findings |
| title_sort | effects of topical ivermectin on imiquimod induced psoriasis in mouse model novel findings |
| url | https://pharmacia.pensoft.net/article/114753/download/pdf/ |
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