NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism
Nicotinamide adenine dinucleotide (NAD+) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD+ precursors or inhibition of NAD+-depleting enzymes can promote mitochondrial...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2022-09-01
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| Series: | Animal Nutrition |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405654522000774 |
| _version_ | 1828379489957052416 |
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| author | Zhongxiang Ren Yetong Xu Tiejun Li Weizhong Sun Zhiru Tang Yongsheng Wang Kaifeng Zhou Jigang Li Qi Ding Kaiyang Liang Liuting Wu Yulong Yin Zhihong Sun |
| author_facet | Zhongxiang Ren Yetong Xu Tiejun Li Weizhong Sun Zhiru Tang Yongsheng Wang Kaifeng Zhou Jigang Li Qi Ding Kaiyang Liang Liuting Wu Yulong Yin Zhihong Sun |
| author_sort | Zhongxiang Ren |
| collection | DOAJ |
| description | Nicotinamide adenine dinucleotide (NAD+) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD+ precursors or inhibition of NAD+-depleting enzymes can promote mitochondrial oxidative phosphorylation and improve host energy utilization efficiency. In addition, increasing evidence indicates that the gut microbiota plays a pivotal role in host metabolism. Theoretically, there should be a close correlation among NAD+, gut microbiota, and host metabolism; however, the information is limited. In this review, we summarize the metabolic process of NAD+ and its impact on host metabolism, the link between gut microbiota and host metabolism, as well as the potential effects of NAD+ on microbial metabolism, providing a new perspective on the interaction between gut microbiota and host metabolism. |
| first_indexed | 2024-12-10T03:41:43Z |
| format | Article |
| id | doaj.art-232b756a8fb44414b11ce02bb8c30b9f |
| institution | Directory Open Access Journal |
| issn | 2405-6545 |
| language | English |
| last_indexed | 2024-12-10T03:41:43Z |
| publishDate | 2022-09-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Animal Nutrition |
| spelling | doaj.art-232b756a8fb44414b11ce02bb8c30b9f2022-12-22T02:03:32ZengKeAi Communications Co., Ltd.Animal Nutrition2405-65452022-09-0110360371NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolismZhongxiang Ren0Yetong Xu1Tiejun Li2Weizhong Sun3Zhiru Tang4Yongsheng Wang5Kaifeng Zhou6Jigang Li7Qi Ding8Kaiyang Liang9Liuting Wu10Yulong Yin11Zhihong Sun12Laboratory for Bio-feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, ChinaLaboratory for Bio-feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, ChinaInstitute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, ChinaLaboratory for Bio-feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, ChinaLaboratory for Bio-feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, ChinaNutrition & Health Research Institute, COFCO, Beijing 102209, ChinaShandong Provincial Animal Husbandry General Station, Jinan 250002, ChinaChongqing Academy of Animal Sciences, Chongqing 500153, ChinaLaboratory for Bio-feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, ChinaLaboratory for Bio-feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, ChinaLaboratory for Bio-feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, ChinaInstitute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China; Corresponding authors.Laboratory for Bio-feed and Molecular Nutrition, College of Animal Science and Technology, Southwest University, Chongqing 400715, China; Corresponding authors.Nicotinamide adenine dinucleotide (NAD+) is an enzyme cofactor, co-substrate, and redox factor in all living cells and is necessary for maintaining cell metabolism. It has been shown that appropriate supplementation of NAD+ precursors or inhibition of NAD+-depleting enzymes can promote mitochondrial oxidative phosphorylation and improve host energy utilization efficiency. In addition, increasing evidence indicates that the gut microbiota plays a pivotal role in host metabolism. Theoretically, there should be a close correlation among NAD+, gut microbiota, and host metabolism; however, the information is limited. In this review, we summarize the metabolic process of NAD+ and its impact on host metabolism, the link between gut microbiota and host metabolism, as well as the potential effects of NAD+ on microbial metabolism, providing a new perspective on the interaction between gut microbiota and host metabolism.http://www.sciencedirect.com/science/article/pii/S2405654522000774NAD+Gut microbiotaHost metabolismMetabolic diseases |
| spellingShingle | Zhongxiang Ren Yetong Xu Tiejun Li Weizhong Sun Zhiru Tang Yongsheng Wang Kaifeng Zhou Jigang Li Qi Ding Kaiyang Liang Liuting Wu Yulong Yin Zhihong Sun NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism Animal Nutrition NAD+ Gut microbiota Host metabolism Metabolic diseases |
| title | NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism |
| title_full | NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism |
| title_fullStr | NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism |
| title_full_unstemmed | NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism |
| title_short | NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism |
| title_sort | nad and its possible role in gut microbiota insights on the mechanisms by which gut microbes influence host metabolism |
| topic | NAD+ Gut microbiota Host metabolism Metabolic diseases |
| url | http://www.sciencedirect.com/science/article/pii/S2405654522000774 |
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