CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from Aspergillus nidulans reveals key conformations for activity regulation and function

CryoEM analysis of the essential native UDP-glucose pyrophosphorylase from Aspergillus nidulans reveals key conformations for activity regulation and function

ABSTRACT Invasive aspergillosis is one of the most serious clinical invasive fungal infections, resulting in a high case fatality rate among immunocompromised patients. The disease is caused by saprophytic molds in the genus Aspergillus, including Aspergillus fumigatus, the most significant pathogen...

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Main Authors: Xu Han, Cecilia D'Angelo, Ainara Otamendi, Javier O. Cifuente, Elisa de Astigarraga, Borja Ochoa-Lizarralde, Martin Grininger, Francoise H. Routier, Marcelo E. Guerin, Jana Fuehring, Oier Etxebeste, Sean R. Connell
Format: Article
Language:English
Published: American Society for Microbiology 2023-08-01
Series:mBio
Subjects:
aspergillosis
cell wall biosynthesis
UDP-glucose pyrophosphorylases
enzyme mechanism
enzyme specificity
cryoEM
Online Access:https://journals.asm.org/doi/10.1128/mbio.00414-23

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