Association between Ambient Particulate Air Pollution and Soluble Biomarkers of Endothelial Function: A Meta-Analysis
Background: The burden of cardiovascular diseases caused by ambient particulate air pollution is universal. An increasing number of studies have investigated the potential effects of exposure to particulate air pollution on endothelial function, which is one of the important mechanisms for the onset...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Toxics |
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| Online Access: | https://www.mdpi.com/2305-6304/12/1/76 |
| _version_ | 1797342430258790400 |
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| author | Kai Wang Lei Lei Ge Li Yang Lan Wanzhou Wang Jiaqi Zhu Qisijing Liu Lihua Ren Shaowei Wu |
| author_facet | Kai Wang Lei Lei Ge Li Yang Lan Wanzhou Wang Jiaqi Zhu Qisijing Liu Lihua Ren Shaowei Wu |
| author_sort | Kai Wang |
| collection | DOAJ |
| description | Background: The burden of cardiovascular diseases caused by ambient particulate air pollution is universal. An increasing number of studies have investigated the potential effects of exposure to particulate air pollution on endothelial function, which is one of the important mechanisms for the onset and development of cardiovascular disease. However, no previous study has conducted a summary analysis of the potential effects of particulate air pollution on endothelial function. Objectives: To summarize the evidence for the potential effects of short-term exposure to ambient particulate air pollution on endothelial function based on existing studies. Methods: A systematic literature search on the relationship between ambient particulate air pollution and biomarkers of endothelial function including endothelin-1 (ET-1), E-selectin, intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) was conducted in PubMed, Scopus, EMBASE, and Web of Science up to 20 May 2023. Subsequently, a meta-analysis was conducted using a random effects model. Results: A total of 18 studies were included in this meta-analysis. A 10 μg/m<sup>3</sup> increase in short-term exposure to ambient PM<sub>2.5</sub> was associated with a 1.55% (95% CI: 0.89%, 2.22%) increase in ICAM-1 and a 1.97% (95% CI: 0.86%, 3.08%) increase in VCAM-1. The associations of ET-1 (0.22%, 95% CI: −4.94%, 5.65%) and E-selectin (3.21%, 95% CI: −0.90% 7.49%) with short-term exposure to ambient PM<sub>2.5</sub> were statistically insignificant. Conclusion: Short-term exposure to ambient PM<sub>2.5</sub> pollution may significantly increase the levels of typical markers of endothelial function, including ICAM-1 and VCAM-1, suggesting potential endothelial dysfunction following ambient air pollution exposure. |
| first_indexed | 2024-03-08T10:33:10Z |
| format | Article |
| id | doaj.art-232f9f9104ad4e62ac329558218162e5 |
| institution | Directory Open Access Journal |
| issn | 2305-6304 |
| language | English |
| last_indexed | 2024-03-08T10:33:10Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxics |
| spelling | doaj.art-232f9f9104ad4e62ac329558218162e52024-01-26T18:41:35ZengMDPI AGToxics2305-63042024-01-011217610.3390/toxics12010076Association between Ambient Particulate Air Pollution and Soluble Biomarkers of Endothelial Function: A Meta-AnalysisKai Wang0Lei Lei1Ge Li2Yang Lan3Wanzhou Wang4Jiaqi Zhu5Qisijing Liu6Lihua Ren7Shaowei Wu8Department of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaDepartment of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaResearch Institute of Public Health, School of Medicine, Nankai University, Tianjin 300071, ChinaSchool of Nursing, Peking University, Beijing 100191, ChinaDepartment of Occupational and Environmental Health, School of Public Health, Xi’an Jiaotong University Health Science Center, Xi’an 710061, ChinaBackground: The burden of cardiovascular diseases caused by ambient particulate air pollution is universal. An increasing number of studies have investigated the potential effects of exposure to particulate air pollution on endothelial function, which is one of the important mechanisms for the onset and development of cardiovascular disease. However, no previous study has conducted a summary analysis of the potential effects of particulate air pollution on endothelial function. Objectives: To summarize the evidence for the potential effects of short-term exposure to ambient particulate air pollution on endothelial function based on existing studies. Methods: A systematic literature search on the relationship between ambient particulate air pollution and biomarkers of endothelial function including endothelin-1 (ET-1), E-selectin, intercellular cell adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) was conducted in PubMed, Scopus, EMBASE, and Web of Science up to 20 May 2023. Subsequently, a meta-analysis was conducted using a random effects model. Results: A total of 18 studies were included in this meta-analysis. A 10 μg/m<sup>3</sup> increase in short-term exposure to ambient PM<sub>2.5</sub> was associated with a 1.55% (95% CI: 0.89%, 2.22%) increase in ICAM-1 and a 1.97% (95% CI: 0.86%, 3.08%) increase in VCAM-1. The associations of ET-1 (0.22%, 95% CI: −4.94%, 5.65%) and E-selectin (3.21%, 95% CI: −0.90% 7.49%) with short-term exposure to ambient PM<sub>2.5</sub> were statistically insignificant. Conclusion: Short-term exposure to ambient PM<sub>2.5</sub> pollution may significantly increase the levels of typical markers of endothelial function, including ICAM-1 and VCAM-1, suggesting potential endothelial dysfunction following ambient air pollution exposure.https://www.mdpi.com/2305-6304/12/1/76ambient air pollutionendothelial functionintercellular adhesion molecule-1vascular cell adhesion molecule-1endothelin-1E-selectin |
| spellingShingle | Kai Wang Lei Lei Ge Li Yang Lan Wanzhou Wang Jiaqi Zhu Qisijing Liu Lihua Ren Shaowei Wu Association between Ambient Particulate Air Pollution and Soluble Biomarkers of Endothelial Function: A Meta-Analysis Toxics ambient air pollution endothelial function intercellular adhesion molecule-1 vascular cell adhesion molecule-1 endothelin-1 E-selectin |
| title | Association between Ambient Particulate Air Pollution and Soluble Biomarkers of Endothelial Function: A Meta-Analysis |
| title_full | Association between Ambient Particulate Air Pollution and Soluble Biomarkers of Endothelial Function: A Meta-Analysis |
| title_fullStr | Association between Ambient Particulate Air Pollution and Soluble Biomarkers of Endothelial Function: A Meta-Analysis |
| title_full_unstemmed | Association between Ambient Particulate Air Pollution and Soluble Biomarkers of Endothelial Function: A Meta-Analysis |
| title_short | Association between Ambient Particulate Air Pollution and Soluble Biomarkers of Endothelial Function: A Meta-Analysis |
| title_sort | association between ambient particulate air pollution and soluble biomarkers of endothelial function a meta analysis |
| topic | ambient air pollution endothelial function intercellular adhesion molecule-1 vascular cell adhesion molecule-1 endothelin-1 E-selectin |
| url | https://www.mdpi.com/2305-6304/12/1/76 |
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