Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity
Abstract The external globus pallidus (GP) firing rate synchronizes the basal ganglia-thalamus-cortex network controlling GABAergic output to different nuclei. In this context, two findings are significant: the activity and GABAergic transmission of the GP modulated by GABA B receptors and the prese...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | Journal of Physiological Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12576-023-00870-8 |
| _version_ | 1827923058082447360 |
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| author | Nelson Villalobos Victor Manuel Magdaleno‐Madrigal |
| author_facet | Nelson Villalobos Victor Manuel Magdaleno‐Madrigal |
| author_sort | Nelson Villalobos |
| collection | DOAJ |
| description | Abstract The external globus pallidus (GP) firing rate synchronizes the basal ganglia-thalamus-cortex network controlling GABAergic output to different nuclei. In this context, two findings are significant: the activity and GABAergic transmission of the GP modulated by GABA B receptors and the presence of the GP-thalamic reticular nucleus (RTn) pathway, the functionality of which is unknown. The functional participation of GABA B receptors through this network in cortical dynamics is feasible because the RTn controls transmission between the thalamus and cortex. To analyze this hypothesis, we used single-unit recordings of RTn neurons and electroencephalograms of the motor cortex (MCx) before and after GP injection of the GABA B agonist baclofen and the antagonist saclofen in anesthetized rats. We found that GABA B agonists increase the spiking rate of the RTn and that this response decreases the spectral density of beta frequency bands in the MCx. Additionally, injections of GABA B antagonists decreased the firing activity of the RTn and reversed the effects in the power spectra of beta frequency bands in the MCx. Our results proved that the GP modulates cortical oscillation dynamics through the GP-RTn network via tonic modulation of RTn activity. |
| first_indexed | 2024-03-13T04:52:11Z |
| format | Article |
| id | doaj.art-2330da04ac234ed29382a42871847c82 |
| institution | Directory Open Access Journal |
| issn | 1880-6562 |
| language | English |
| last_indexed | 2024-03-13T04:52:11Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Physiological Sciences |
| spelling | doaj.art-2330da04ac234ed29382a42871847c822023-06-18T11:08:45ZengBMCJournal of Physiological Sciences1880-65622023-06-0173111410.1186/s12576-023-00870-8Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activityNelson Villalobos0Victor Manuel Magdaleno‐Madrigal1Academia de Fisiología, Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, Colonia Casco de Santo TomásLaboratorio de Neuromodulación Experimental, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente MuñizAbstract The external globus pallidus (GP) firing rate synchronizes the basal ganglia-thalamus-cortex network controlling GABAergic output to different nuclei. In this context, two findings are significant: the activity and GABAergic transmission of the GP modulated by GABA B receptors and the presence of the GP-thalamic reticular nucleus (RTn) pathway, the functionality of which is unknown. The functional participation of GABA B receptors through this network in cortical dynamics is feasible because the RTn controls transmission between the thalamus and cortex. To analyze this hypothesis, we used single-unit recordings of RTn neurons and electroencephalograms of the motor cortex (MCx) before and after GP injection of the GABA B agonist baclofen and the antagonist saclofen in anesthetized rats. We found that GABA B agonists increase the spiking rate of the RTn and that this response decreases the spectral density of beta frequency bands in the MCx. Additionally, injections of GABA B antagonists decreased the firing activity of the RTn and reversed the effects in the power spectra of beta frequency bands in the MCx. Our results proved that the GP modulates cortical oscillation dynamics through the GP-RTn network via tonic modulation of RTn activity.https://doi.org/10.1186/s12576-023-00870-8Globus pallidusThalamic reticular nucleusTonic inhibitionBeta bandDesynchronizationGABA B receptor |
| spellingShingle | Nelson Villalobos Victor Manuel Magdaleno‐Madrigal Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity Journal of Physiological Sciences Globus pallidus Thalamic reticular nucleus Tonic inhibition Beta band Desynchronization GABA B receptor |
| title | Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity |
| title_full | Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity |
| title_fullStr | Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity |
| title_full_unstemmed | Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity |
| title_short | Pallidal GABA B receptors: involvement in cortex beta dynamics and thalamic reticular nucleus activity |
| title_sort | pallidal gaba b receptors involvement in cortex beta dynamics and thalamic reticular nucleus activity |
| topic | Globus pallidus Thalamic reticular nucleus Tonic inhibition Beta band Desynchronization GABA B receptor |
| url | https://doi.org/10.1186/s12576-023-00870-8 |
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