Mitochondrial Peroxiredoxin-IIF (PRXIIF) Activity and Function during Seed Aging
Mitochondria play a major role in energy metabolism, particularly in cell respiration, cellular metabolism, and signal transduction, and are also involved in other processes, such as cell signaling, cell cycle control, cell growth, differentiation and apoptosis. Programmed cell death is associated w...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/7/1226 |
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| author | Ewelina A. Klupczyńska Karl-Josef Dietz Arleta Małecka Ewelina Ratajczak |
| author_facet | Ewelina A. Klupczyńska Karl-Josef Dietz Arleta Małecka Ewelina Ratajczak |
| author_sort | Ewelina A. Klupczyńska |
| collection | DOAJ |
| description | Mitochondria play a major role in energy metabolism, particularly in cell respiration, cellular metabolism, and signal transduction, and are also involved in other processes, such as cell signaling, cell cycle control, cell growth, differentiation and apoptosis. Programmed cell death is associated with the production of reactive oxygen species (ROS) and a concomitant decrease in antioxidant capacity, which, in turn, determines the aging of living organisms and organs and thus also seeds. During the aging process, cell redox homeostasis is disrupted, and these changes decrease the viability of stored seeds. Mitochondrial peroxiredoxin-IIF (PRXIIF), a thiol peroxidase, has a significant role in protecting the cell and sensing oxidative stress that occurs during the disturbance of redox homeostasis. Thioredoxins (TRXs), which function as redox transmitters and switch protein function in mitochondria, can regulate respiratory metabolism. TRXs serve as electron donors to PRXIIF, as shown in Arabidopsis. In contrast, sulfiredoxin (SRX) can regenerate mitochondrial PRXIIF once hyperoxidized to sulfinic acid. To protect against oxidative stress, another type of thiol peroxidases, glutathione peroxidase-like protein (GPXL), is important and receives electrons from the TRX system. They remove peroxides produced in the mitochondrial matrix. However, the TRX/PRX and TRX/GPXL systems are not well understood in mitochondria. Knowledge of both systems is important because these systems play an important role in stress sensing, response and acclimation, including redox imbalance and generation of ROS and reactive nitrogen species (RNS). The TRX/PRX and TRX/GPXL systems are important for maintaining cellular ROS homeostasis and maintaining redox homeostasis under stress conditions. This minireview focuses on the functions of PRXIIF discovered in plant cells approximately 20 years ago and addresses the question of how PRXIIF affects seed viability maintenance and aging. Increasing evidence suggests that the mitochondrial PRXIIF plays a major role in metabolic processes in seeds, which was not previously known. |
| first_indexed | 2024-03-09T03:46:10Z |
| format | Article |
| id | doaj.art-23311dffa8034dfb98953b9f9b830a0d |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T03:46:10Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-23311dffa8034dfb98953b9f9b830a0d2023-12-03T14:33:21ZengMDPI AGAntioxidants2076-39212022-06-01117122610.3390/antiox11071226Mitochondrial Peroxiredoxin-IIF (PRXIIF) Activity and Function during Seed AgingEwelina A. Klupczyńska0Karl-Josef Dietz1Arleta Małecka2Ewelina Ratajczak3Institute of Dendrology, Polish Academy of Sciences, 62-035 Kórnik, PolandBiochemistry and Physiology of Plants, Faculty of Biology, Bielefeld University, 33615 Bielefeld, GermanyLaboratory of Biotechnology, Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, 61-614 Poznan, PolandInstitute of Dendrology, Polish Academy of Sciences, 62-035 Kórnik, PolandMitochondria play a major role in energy metabolism, particularly in cell respiration, cellular metabolism, and signal transduction, and are also involved in other processes, such as cell signaling, cell cycle control, cell growth, differentiation and apoptosis. Programmed cell death is associated with the production of reactive oxygen species (ROS) and a concomitant decrease in antioxidant capacity, which, in turn, determines the aging of living organisms and organs and thus also seeds. During the aging process, cell redox homeostasis is disrupted, and these changes decrease the viability of stored seeds. Mitochondrial peroxiredoxin-IIF (PRXIIF), a thiol peroxidase, has a significant role in protecting the cell and sensing oxidative stress that occurs during the disturbance of redox homeostasis. Thioredoxins (TRXs), which function as redox transmitters and switch protein function in mitochondria, can regulate respiratory metabolism. TRXs serve as electron donors to PRXIIF, as shown in Arabidopsis. In contrast, sulfiredoxin (SRX) can regenerate mitochondrial PRXIIF once hyperoxidized to sulfinic acid. To protect against oxidative stress, another type of thiol peroxidases, glutathione peroxidase-like protein (GPXL), is important and receives electrons from the TRX system. They remove peroxides produced in the mitochondrial matrix. However, the TRX/PRX and TRX/GPXL systems are not well understood in mitochondria. Knowledge of both systems is important because these systems play an important role in stress sensing, response and acclimation, including redox imbalance and generation of ROS and reactive nitrogen species (RNS). The TRX/PRX and TRX/GPXL systems are important for maintaining cellular ROS homeostasis and maintaining redox homeostasis under stress conditions. This minireview focuses on the functions of PRXIIF discovered in plant cells approximately 20 years ago and addresses the question of how PRXIIF affects seed viability maintenance and aging. Increasing evidence suggests that the mitochondrial PRXIIF plays a major role in metabolic processes in seeds, which was not previously known.https://www.mdpi.com/2076-3921/11/7/1226seed agingperoxiredoxin-IIFthioredoxinredox regulation |
| spellingShingle | Ewelina A. Klupczyńska Karl-Josef Dietz Arleta Małecka Ewelina Ratajczak Mitochondrial Peroxiredoxin-IIF (PRXIIF) Activity and Function during Seed Aging Antioxidants seed aging peroxiredoxin-IIF thioredoxin redox regulation |
| title | Mitochondrial Peroxiredoxin-IIF (PRXIIF) Activity and Function during Seed Aging |
| title_full | Mitochondrial Peroxiredoxin-IIF (PRXIIF) Activity and Function during Seed Aging |
| title_fullStr | Mitochondrial Peroxiredoxin-IIF (PRXIIF) Activity and Function during Seed Aging |
| title_full_unstemmed | Mitochondrial Peroxiredoxin-IIF (PRXIIF) Activity and Function during Seed Aging |
| title_short | Mitochondrial Peroxiredoxin-IIF (PRXIIF) Activity and Function during Seed Aging |
| title_sort | mitochondrial peroxiredoxin iif prxiif activity and function during seed aging |
| topic | seed aging peroxiredoxin-IIF thioredoxin redox regulation |
| url | https://www.mdpi.com/2076-3921/11/7/1226 |
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