Aryl Urea Based Scaffolds for Multitarget Drug Discovery in Anticancer Immunotherapies

Aryl Urea Based Scaffolds for Multitarget Drug Discovery in Anticancer Immunotherapies

Twenty-one styryl and phenethyl aryl ureas have been synthetized and biologically evaluated as multitarget inhibitors of Vascular endothelial growth factor receptor-2 VEGFR-2 and programmed death-ligand-1 (PD-L1) proteins in order to overcome resistance phenomena offered by cancer. The antiprolifera...

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Bibliographic Details
Main Authors: Celia Martín-Beltrán, Raquel Gil-Edo, Germán Hernández-Ribelles, Raül Agut, Pilar Marí-Mezquita, Miguel Carda, Eva Falomir
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Pharmaceuticals
Subjects:
styryl aryl urea
phenethyl aryl urea
PD-L1
VEGFR-2
c-Myc
multitarget inhibitors
Online Access:https://www.mdpi.com/1424-8247/14/4/337

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