Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review
Ovarian germ cell tumors (OGCTs) are rare in adults; indeed, they occur predominantly in children, adolescents, and young adults, and they account for approximately 11% of cancer diagnoses in these groups. Because OGCTs are rare tumors, our current understanding of them is sparse; this is because fe...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/15/11/2990 |
| _version_ | 1797597777461510144 |
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| author | Mariana Tomazini Pinto Gisele Eiras Martins Ana Glenda Santarosa Vieira Janaina Mello Soares Galvão Cristiano de Pádua Souza Carla Renata Pacheco Donato Macedo Luiz Fernando Lopes |
| author_facet | Mariana Tomazini Pinto Gisele Eiras Martins Ana Glenda Santarosa Vieira Janaina Mello Soares Galvão Cristiano de Pádua Souza Carla Renata Pacheco Donato Macedo Luiz Fernando Lopes |
| author_sort | Mariana Tomazini Pinto |
| collection | DOAJ |
| description | Ovarian germ cell tumors (OGCTs) are rare in adults; indeed, they occur predominantly in children, adolescents, and young adults, and they account for approximately 11% of cancer diagnoses in these groups. Because OGCTs are rare tumors, our current understanding of them is sparse; this is because few studies have investigated the molecular basis of pediatric and adult cancers. Here, we review the etiopathogenesis of OGCTs in children and adults, and we address the molecular landscape of these tumors, including integrated genomic analysis, microRNAs, DNA methylation, the molecular implications of treatment resistance, and the development of in vitro and in vivo models. An elucidation of potential molecular alterations may provide a novel field for understanding the pathogenesis, tumorigenesis, diagnostic markers, and genetic peculiarity of the rarity and complexity of OGCTs. |
| first_indexed | 2024-03-11T03:10:15Z |
| format | Article |
| id | doaj.art-23324474c84444ecbe7e479a51fc42b4 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T03:10:15Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-23324474c84444ecbe7e479a51fc42b42023-11-18T07:39:14ZengMDPI AGCancers2072-66942023-05-011511299010.3390/cancers15112990Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A ReviewMariana Tomazini Pinto0Gisele Eiras Martins1Ana Glenda Santarosa Vieira2Janaina Mello Soares Galvão3Cristiano de Pádua Souza4Carla Renata Pacheco Donato Macedo5Luiz Fernando Lopes6Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784400, BrazilBrazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), Barretos 14784400, BrazilBrazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), Barretos 14784400, BrazilMolecular Oncology Research Center, Barretos Cancer Hospital, Barretos 14784400, BrazilMedical Oncology Department, Barretos Cancer Hospital, Barretos 14784400, BrazilBrazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), Barretos 14784400, BrazilBrazilian Childhood Germ Cell Tumor Study Group, The Brazilian Pediatric Oncology Society (SOBOPE), Barretos 14784400, BrazilOvarian germ cell tumors (OGCTs) are rare in adults; indeed, they occur predominantly in children, adolescents, and young adults, and they account for approximately 11% of cancer diagnoses in these groups. Because OGCTs are rare tumors, our current understanding of them is sparse; this is because few studies have investigated the molecular basis of pediatric and adult cancers. Here, we review the etiopathogenesis of OGCTs in children and adults, and we address the molecular landscape of these tumors, including integrated genomic analysis, microRNAs, DNA methylation, the molecular implications of treatment resistance, and the development of in vitro and in vivo models. An elucidation of potential molecular alterations may provide a novel field for understanding the pathogenesis, tumorigenesis, diagnostic markers, and genetic peculiarity of the rarity and complexity of OGCTs.https://www.mdpi.com/2072-6694/15/11/2990ovarian cancergerm cell tumorsgenomicsepigenomicspediatric and adult |
| spellingShingle | Mariana Tomazini Pinto Gisele Eiras Martins Ana Glenda Santarosa Vieira Janaina Mello Soares Galvão Cristiano de Pádua Souza Carla Renata Pacheco Donato Macedo Luiz Fernando Lopes Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review Cancers ovarian cancer germ cell tumors genomics epigenomics pediatric and adult |
| title | Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review |
| title_full | Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review |
| title_fullStr | Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review |
| title_full_unstemmed | Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review |
| title_short | Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review |
| title_sort | molecular biology of pediatric and adult ovarian germ cell tumors a review |
| topic | ovarian cancer germ cell tumors genomics epigenomics pediatric and adult |
| url | https://www.mdpi.com/2072-6694/15/11/2990 |
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