Clofazimine, but Not Isoniazid or Rifampicin, Augments Platelet Activation in vitro

Clofazimine, but Not Isoniazid or Rifampicin, Augments Platelet Activation in vitro

Although the inclusion of the cationic amphiphilic, anti-mycobacterial agent, clofazimine, in the chemotherapeutic regimens of patients with multidrug-resistant tuberculosis (TB) has contributed to improved outcomes, concerns remain about the cardiotoxic potential of this agent. Accordingly, the cur...

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Bibliographic Details
Main Authors: Ronald Anderson, Annette J. Theron, Jan G. Nel, Chrisna Durandt, Moloko C. Cholo, Charles Feldman, Gregory R. Tintinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
adenosine 5′-diphosphate
clofazimine
isoniazid
neutrophils
platelets
P-selectin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01335/full

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