Extracellular Vesicle-Derived miR-105-5p Promotes Malignant Phenotypes of Esophageal Squamous Cell Carcinoma by Targeting SPARCL1 via FAK/AKT Signaling Pathway

Extracellular Vesicle-Derived miR-105-5p Promotes Malignant Phenotypes of Esophageal Squamous Cell Carcinoma by Targeting SPARCL1 via FAK/AKT Signaling Pathway

Objective: Esophageal squamous cell carcinoma (ESCC) presents high morbidity and mortality. It was demonstrated that blood-derived vesicles can facilitate ESCC development and transmit regulating signals. However, the molecular mechanism of vesicle miRNA secreted by tumor cells affecting ESCC progre...

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Bibliographic Details
Main Authors: Binjun He, Kang Zhang, Xiaoliang Han, Chao Su, Jiaming Zhao, Guoxia Wang, Guzong Wang, Liuya Zhang, Wenbin Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Genetics
Subjects:
EVs
miR-105-5p
SPARCL1
ESCC
FAK/AKT
proliferation
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2022.819699/full

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