Cuproptosis-a potential target for the treatment of osteoporosis
Osteoporosis is an age-related disease of bone metabolism marked by reduced bone mineral density and impaired bone strength. The disease causes the bones to weaken and break more easily. Osteoclasts participate in bone resorption more than osteoblasts participate in bone formation, disrupting bone h...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-05-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1135181/full |
| _version_ | 1797833023073288192 |
|---|---|
| author | Dinglin Li Zhonghua Gao Qian Li Xiangjie Liu Hao Liu |
| author_facet | Dinglin Li Zhonghua Gao Qian Li Xiangjie Liu Hao Liu |
| author_sort | Dinglin Li |
| collection | DOAJ |
| description | Osteoporosis is an age-related disease of bone metabolism marked by reduced bone mineral density and impaired bone strength. The disease causes the bones to weaken and break more easily. Osteoclasts participate in bone resorption more than osteoblasts participate in bone formation, disrupting bone homeostasis and leading to osteoporosis. Currently, drug therapy for osteoporosis includes calcium supplements, vitamin D, parathyroid hormone, estrogen, calcitonin, bisphosphates, and other medications. These medications are effective in treating osteoporosis but have side effects. Copper is a necessary trace element in the human body, and studies have shown that it links to the development of osteoporosis. Cuproptosis is a recently proposed new type of cell death. Copper-induced cell death regulates by lipoylated components mediated via mitochondrial ferredoxin 1; that is, copper binds directly to the lipoylated components of the tricarboxylic acid cycle, resulting in lipoylated protein accumulation and subsequent loss of iron-sulfur cluster proteins, leading to proteotoxic stress and eventually cell death. Therapeutic options for tumor disorders include targeting the intracellular toxicity of copper and cuproptosis. The hypoxic environment in bone and the metabolic pathway of glycolysis to provide energy in cells can inhibit cuproptosis, which may promote the survival and proliferation of various cells, including osteoblasts, osteoclasts, effector T cells, and macrophages, thereby mediating the osteoporosis process. As a result, our group tried to explain the relationship between the role of cuproptosis and its essential regulatory genes, as well as the pathological mechanism of osteoporosis and its effects on various cells. This study intends to investigate a new treatment approach for the clinical treatment of osteoporosis that is beneficial to the treatment of osteoporosis. |
| first_indexed | 2024-04-09T14:18:11Z |
| format | Article |
| id | doaj.art-23338f63c317403bb007a7e6a11c41d6 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T14:18:11Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-23338f63c317403bb007a7e6a11c41d62023-05-05T05:48:27ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-05-011410.3389/fendo.2023.11351811135181Cuproptosis-a potential target for the treatment of osteoporosisDinglin Li0Zhonghua Gao1Qian Li2Xiangjie Liu3Hao Liu4Department of Integrated Traditional Chinese and Western Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Geriatrics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Geriatrics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Integrated Traditional Chinese and Western Medicine, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaOsteoporosis is an age-related disease of bone metabolism marked by reduced bone mineral density and impaired bone strength. The disease causes the bones to weaken and break more easily. Osteoclasts participate in bone resorption more than osteoblasts participate in bone formation, disrupting bone homeostasis and leading to osteoporosis. Currently, drug therapy for osteoporosis includes calcium supplements, vitamin D, parathyroid hormone, estrogen, calcitonin, bisphosphates, and other medications. These medications are effective in treating osteoporosis but have side effects. Copper is a necessary trace element in the human body, and studies have shown that it links to the development of osteoporosis. Cuproptosis is a recently proposed new type of cell death. Copper-induced cell death regulates by lipoylated components mediated via mitochondrial ferredoxin 1; that is, copper binds directly to the lipoylated components of the tricarboxylic acid cycle, resulting in lipoylated protein accumulation and subsequent loss of iron-sulfur cluster proteins, leading to proteotoxic stress and eventually cell death. Therapeutic options for tumor disorders include targeting the intracellular toxicity of copper and cuproptosis. The hypoxic environment in bone and the metabolic pathway of glycolysis to provide energy in cells can inhibit cuproptosis, which may promote the survival and proliferation of various cells, including osteoblasts, osteoclasts, effector T cells, and macrophages, thereby mediating the osteoporosis process. As a result, our group tried to explain the relationship between the role of cuproptosis and its essential regulatory genes, as well as the pathological mechanism of osteoporosis and its effects on various cells. This study intends to investigate a new treatment approach for the clinical treatment of osteoporosis that is beneficial to the treatment of osteoporosis.https://www.frontiersin.org/articles/10.3389/fendo.2023.1135181/fullosteoporosiscoppercuproptosiscuproptosis-related genesinflammation |
| spellingShingle | Dinglin Li Zhonghua Gao Qian Li Xiangjie Liu Hao Liu Cuproptosis-a potential target for the treatment of osteoporosis Frontiers in Endocrinology osteoporosis copper cuproptosis cuproptosis-related genes inflammation |
| title | Cuproptosis-a potential target for the treatment of osteoporosis |
| title_full | Cuproptosis-a potential target for the treatment of osteoporosis |
| title_fullStr | Cuproptosis-a potential target for the treatment of osteoporosis |
| title_full_unstemmed | Cuproptosis-a potential target for the treatment of osteoporosis |
| title_short | Cuproptosis-a potential target for the treatment of osteoporosis |
| title_sort | cuproptosis a potential target for the treatment of osteoporosis |
| topic | osteoporosis copper cuproptosis cuproptosis-related genes inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1135181/full |
| work_keys_str_mv | AT dinglinli cuproptosisapotentialtargetforthetreatmentofosteoporosis AT zhonghuagao cuproptosisapotentialtargetforthetreatmentofosteoporosis AT qianli cuproptosisapotentialtargetforthetreatmentofosteoporosis AT xiangjieliu cuproptosisapotentialtargetforthetreatmentofosteoporosis AT haoliu cuproptosisapotentialtargetforthetreatmentofosteoporosis |