Highly efficient method for the synthesis of substituted benzimidazoles using sodium metabisulfite adsorbed on silica gel
A simple efficient and economical method is established to synthesize N-substituted Benzimidazole derivatives in moderate to excellent yield using Sodium metabisulfite adsorbed on silica gel in ethanol. The method is important as most of the reactions are completed at ambient temperature with easy p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715622001229 |
| _version_ | 1811294604538937344 |
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| author | Manoj Kumar Sushil K. Pandey Neha Chaudhary Anand Mishra Deepshikha Gupta |
| author_facet | Manoj Kumar Sushil K. Pandey Neha Chaudhary Anand Mishra Deepshikha Gupta |
| author_sort | Manoj Kumar |
| collection | DOAJ |
| description | A simple efficient and economical method is established to synthesize N-substituted Benzimidazole derivatives in moderate to excellent yield using Sodium metabisulfite adsorbed on silica gel in ethanol. The method is important as most of the reactions are completed at ambient temperature with easy product isolation as reaction mass can be directly used for column purification after the removal of solvent. Clean reaction products were obtained in good to excellent yields. |
| first_indexed | 2024-04-13T05:19:54Z |
| format | Article |
| id | doaj.art-23358955c5a7462bbbf4df6ddc1572bf |
| institution | Directory Open Access Journal |
| issn | 2211-7156 |
| language | English |
| last_indexed | 2024-04-13T05:19:54Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj.art-23358955c5a7462bbbf4df6ddc1572bf2022-12-22T03:00:46ZengElsevierResults in Chemistry2211-71562022-01-014100403Highly efficient method for the synthesis of substituted benzimidazoles using sodium metabisulfite adsorbed on silica gelManoj Kumar0Sushil K. Pandey1Neha Chaudhary2Anand Mishra3Deepshikha Gupta4Amity Institute of Applied Sciences, Amity University, Sector-125, Noida 201301, India; Jubilant Biosys Limited, 15A, Knowledge Park II, Greater Noida 201310, IndiaJubilant Biosys Limited, 15A, Knowledge Park II, Greater Noida 201310, IndiaAmity Institute of Applied Sciences, Amity University, Sector-125, Noida 201301, IndiaJubilant Biosys Limited, 15A, Knowledge Park II, Greater Noida 201310, IndiaAmity Institute of Applied Sciences, Amity University, Sector-125, Noida 201301, India; Corresponding author.A simple efficient and economical method is established to synthesize N-substituted Benzimidazole derivatives in moderate to excellent yield using Sodium metabisulfite adsorbed on silica gel in ethanol. The method is important as most of the reactions are completed at ambient temperature with easy product isolation as reaction mass can be directly used for column purification after the removal of solvent. Clean reaction products were obtained in good to excellent yields.http://www.sciencedirect.com/science/article/pii/S2211715622001229BenzimidazolesSilica gelSodium metabisulfite |
| spellingShingle | Manoj Kumar Sushil K. Pandey Neha Chaudhary Anand Mishra Deepshikha Gupta Highly efficient method for the synthesis of substituted benzimidazoles using sodium metabisulfite adsorbed on silica gel Results in Chemistry Benzimidazoles Silica gel Sodium metabisulfite |
| title | Highly efficient method for the synthesis of substituted benzimidazoles using sodium metabisulfite adsorbed on silica gel |
| title_full | Highly efficient method for the synthesis of substituted benzimidazoles using sodium metabisulfite adsorbed on silica gel |
| title_fullStr | Highly efficient method for the synthesis of substituted benzimidazoles using sodium metabisulfite adsorbed on silica gel |
| title_full_unstemmed | Highly efficient method for the synthesis of substituted benzimidazoles using sodium metabisulfite adsorbed on silica gel |
| title_short | Highly efficient method for the synthesis of substituted benzimidazoles using sodium metabisulfite adsorbed on silica gel |
| title_sort | highly efficient method for the synthesis of substituted benzimidazoles using sodium metabisulfite adsorbed on silica gel |
| topic | Benzimidazoles Silica gel Sodium metabisulfite |
| url | http://www.sciencedirect.com/science/article/pii/S2211715622001229 |
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