| Summary: | <i>Clinacanthus nutans</i> is known to be an anticancer and antiviral agent, and <i>Strobilanthes crispus</i> has proven to be an antidiuretic and antidiabetic agent. However, there is a high possibility that these plants possess multiple beneficial properties, such as antimicrobial and wound healing properties. This study aims to assess the wound healing, antioxidant, and antimicrobial properties of <i>Clinacanthus nutans</i> and <i>Strobilanthes crispus</i>. The <i>Clinacanthus nutans</i> and <i>Strobilanthes crispus</i> leaves were dried, ground, and extracted with ethanol, acetone, and chloroform through cold maceration. In a modified scratch assay with co-incubation of skin fibroblast and Methicillin-resistant <i>Staphylococcus aureus</i>, <i>Clinacanthus nutans</i> and <i>Strobilanthes crispus</i> extracts were assessed for their wound healing potential, and the antimicrobial activities of <i>Clinacanthus nutans</i> and <i>Strobilanthes crispus</i> extracts were performed on a panel of Gram-positive and Gram-negative bacteria on Mueller–Hinton agar based on a disc diffusion assay. To assess for antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH), total phenolic and total flavonoid assays were conducted. In the modified scratch assay, <i>Clinacanthus nutans</i> extracts aided in the wound healing activity while in the presence of MRSA, and <i>Strobilanthes crispus</i> extracts were superior in antimicrobial and wound healing activities. In addition, <i>Strobilanthes crispus</i> extracts were superior to <i>Clinacanthus nutans</i> extracts against <i>Pseudomonas aeruginosa</i> on Mueller–Hinton agar. Acetone-extracted <i>Clinacanthus nutans</i> contained the highest level of antioxidant in comparison with other <i>Clinacanthus nutans</i> extracts.
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