Turmeric Extracts as a Protective Natural Compound Against Hepatotoxicity Induced by Lead Nitrate in Male Albino Rat Model
Excessive exposure to lead may damage the liver by increasing oxidative stress, leading to many serious diseases. Dietary antioxidants may protect the liver from damage. Therefore, the effect of ethanolic and aqueous turmeric extracts against lead-induced liver damage was evaluated by estimating liv...
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| Format: | Article |
| Language: | Arabic |
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The Union of Arab Universities
2021-12-01
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| Series: | Arab Universities Journal of Agricultural Sciences |
| Subjects: | |
| Online Access: | https://ajs.journals.ekb.eg/article_211683_a33d38e4defdc0c592499c68e4b78c81.pdf |
| _version_ | 1797269854355456000 |
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| author | Abd el-Fattah Abd el-Fattah Medhat Abozid Kamal Mahmoud |
| author_facet | Abd el-Fattah Abd el-Fattah Medhat Abozid Kamal Mahmoud |
| author_sort | Abd el-Fattah Abd el-Fattah |
| collection | DOAJ |
| description | Excessive exposure to lead may damage the liver by increasing oxidative stress, leading to many serious diseases. Dietary antioxidants may protect the liver from damage. Therefore, the effect of ethanolic and aqueous turmeric extracts against lead-induced liver damage was evaluated by estimating liver function and antioxidant/oxidative stress biomarkers. Forty rats were divided into group (A) served as the control and group (B) was treated with 93 mg/kg b.wt. lead nitrate; while group (C) and group (D) were treated as group B in addition to 400 mg/kg b.wt. of turmeric aqueous and ethanolic extracts, respectively. Group B showed a significant increase in the activities of alanine transaminase by 10 folds, aspartate transaminase by 9 folds, alkaline phosphatase by 3 folds and the level of malondialdehyde by 10 folds, while showed a significant decrease in albumin by 60%, total protein by 54.5%, and superoxide dismutase by 80.5%, catalase by 75% and glutathione by 71.6% in comparison with those of the control group. On the other hand, turmeric treatments (groups C and D) led to a readjustment of levels for such biomarkers. Collectively, these results demonstrate the potential of turmeric extracts (particularly the ethanolic extract) to improve the fatal effect of lead in a rat model. |
| first_indexed | 2024-04-25T01:54:59Z |
| format | Article |
| id | doaj.art-233a89130c5042d69de4a4b225f78ce9 |
| institution | Directory Open Access Journal |
| issn | 1110-2675 2636-3585 |
| language | Arabic |
| last_indexed | 2024-04-25T01:54:59Z |
| publishDate | 2021-12-01 |
| publisher | The Union of Arab Universities |
| record_format | Article |
| series | Arab Universities Journal of Agricultural Sciences |
| spelling | doaj.art-233a89130c5042d69de4a4b225f78ce92024-03-07T17:27:41ZaraThe Union of Arab UniversitiesArab Universities Journal of Agricultural Sciences1110-26752636-35852021-12-0129381382210.21608/ajs.2021.75154.1374211683Turmeric Extracts as a Protective Natural Compound Against Hepatotoxicity Induced by Lead Nitrate in Male Albino Rat ModelAbd el-Fattah Abd el-Fattah0Medhat Abozid1Kamal Mahmoud2Ministry of Health and Population, Cairo, Egypt.Biochemistry department, Faculty of Agriculture, Menoufia University, Shebin El-Kom, Menoufia, Egypt.Biochemistry department, Faculty of Agriculture, Menoufia University, Shebin El-Kom, Menoufia, EgyptExcessive exposure to lead may damage the liver by increasing oxidative stress, leading to many serious diseases. Dietary antioxidants may protect the liver from damage. Therefore, the effect of ethanolic and aqueous turmeric extracts against lead-induced liver damage was evaluated by estimating liver function and antioxidant/oxidative stress biomarkers. Forty rats were divided into group (A) served as the control and group (B) was treated with 93 mg/kg b.wt. lead nitrate; while group (C) and group (D) were treated as group B in addition to 400 mg/kg b.wt. of turmeric aqueous and ethanolic extracts, respectively. Group B showed a significant increase in the activities of alanine transaminase by 10 folds, aspartate transaminase by 9 folds, alkaline phosphatase by 3 folds and the level of malondialdehyde by 10 folds, while showed a significant decrease in albumin by 60%, total protein by 54.5%, and superoxide dismutase by 80.5%, catalase by 75% and glutathione by 71.6% in comparison with those of the control group. On the other hand, turmeric treatments (groups C and D) led to a readjustment of levels for such biomarkers. Collectively, these results demonstrate the potential of turmeric extracts (particularly the ethanolic extract) to improve the fatal effect of lead in a rat model.https://ajs.journals.ekb.eg/article_211683_a33d38e4defdc0c592499c68e4b78c81.pdfturmericlead nitrateliver functionantioxidantextracts |
| spellingShingle | Abd el-Fattah Abd el-Fattah Medhat Abozid Kamal Mahmoud Turmeric Extracts as a Protective Natural Compound Against Hepatotoxicity Induced by Lead Nitrate in Male Albino Rat Model Arab Universities Journal of Agricultural Sciences turmeric lead nitrate liver function antioxidant extracts |
| title | Turmeric Extracts as a Protective Natural Compound Against Hepatotoxicity Induced by Lead Nitrate in Male Albino Rat Model |
| title_full | Turmeric Extracts as a Protective Natural Compound Against Hepatotoxicity Induced by Lead Nitrate in Male Albino Rat Model |
| title_fullStr | Turmeric Extracts as a Protective Natural Compound Against Hepatotoxicity Induced by Lead Nitrate in Male Albino Rat Model |
| title_full_unstemmed | Turmeric Extracts as a Protective Natural Compound Against Hepatotoxicity Induced by Lead Nitrate in Male Albino Rat Model |
| title_short | Turmeric Extracts as a Protective Natural Compound Against Hepatotoxicity Induced by Lead Nitrate in Male Albino Rat Model |
| title_sort | turmeric extracts as a protective natural compound against hepatotoxicity induced by lead nitrate in male albino rat model |
| topic | turmeric lead nitrate liver function antioxidant extracts |
| url | https://ajs.journals.ekb.eg/article_211683_a33d38e4defdc0c592499c68e4b78c81.pdf |
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