Simultaneous siRNA targeting of Src and downstream signaling molecules inhibit tumor formation and metastasis of a human model breast cancer cell line.

Simultaneous siRNA targeting of Src and downstream signaling molecules inhibit tumor formation and metastasis of a human model breast cancer cell line.

Src and signaling molecules downstream of Src, including signal transducer and activator of transcription 3 (Stat3) and cMyc, have been implicated in the development, maintenance and/or progression of several types of human cancers, including breast cancer. Here we report the ability of siRNA-mediat...

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Podrobná bibliografie
Hlavní autoři: Jeffrey D Bjorge, Andy S Pang, Melanie Funnell, Ke Yun Chen, Roman Diaz, Anthony M Magliocco, Donald J Fujita
Médium: Článek
Jazyk:English
Vydáno: Public Library of Science (PLoS) 2011-04-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC3082570?pdf=render

Internet

http://europepmc.org/articles/PMC3082570?pdf=render

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