Control of Maternal-to-Zygotic Transition in Human Embryos and Other Animal Species (Especially Mouse): Similarities and Differences
Maternal-to-zygotic transition (MZT) of the control of early post-fertilization development is a key-event conditioning the fate of the future embryo, fetus and newborn. Because of the relative paucity of data concerning human embryos, due to ethical concerns and the poor availability of human embry...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/15/8562 |
| _version_ | 1797432819737165824 |
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| author | Jan Tesarik |
| author_facet | Jan Tesarik |
| author_sort | Jan Tesarik |
| collection | DOAJ |
| description | Maternal-to-zygotic transition (MZT) of the control of early post-fertilization development is a key-event conditioning the fate of the future embryo, fetus and newborn. Because of the relative paucity of data concerning human embryos, due to ethical concerns and the poor availability of human embryos donated for research, most data have to be derived from animal models, among which those obtained using mouse embryos are most prevalent. However, data obtained by studies performed in non-mammalian specie can also provide useful information. For this reason, this review focuses on similarities and differences of MZT control mechanisms in humans and other species, with particular attention to the mouse. A number of molecular pathways controlling MZT in mice and humans are compared, pointing out those that could be at the origin of further focused experimental studies and the development of new diagnostic tools based on the translational medicine principles. Data concerning possible candidate molecules to be included in these studies are identified. |
| first_indexed | 2024-03-09T10:08:19Z |
| format | Article |
| id | doaj.art-233b18e904614a2e876ff27848dfc34f |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T10:08:19Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-233b18e904614a2e876ff27848dfc34f2023-12-01T22:58:07ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-08-012315856210.3390/ijms23158562Control of Maternal-to-Zygotic Transition in Human Embryos and Other Animal Species (Especially Mouse): Similarities and DifferencesJan Tesarik0MARGen Clinic, 18006 Granada, SpainMaternal-to-zygotic transition (MZT) of the control of early post-fertilization development is a key-event conditioning the fate of the future embryo, fetus and newborn. Because of the relative paucity of data concerning human embryos, due to ethical concerns and the poor availability of human embryos donated for research, most data have to be derived from animal models, among which those obtained using mouse embryos are most prevalent. However, data obtained by studies performed in non-mammalian specie can also provide useful information. For this reason, this review focuses on similarities and differences of MZT control mechanisms in humans and other species, with particular attention to the mouse. A number of molecular pathways controlling MZT in mice and humans are compared, pointing out those that could be at the origin of further focused experimental studies and the development of new diagnostic tools based on the translational medicine principles. Data concerning possible candidate molecules to be included in these studies are identified.https://www.mdpi.com/1422-0067/23/15/8562maternal-to-zygotic transitionzygotic gene activationmaternal mRNA decayM-decayZ-decayDNA transcription |
| spellingShingle | Jan Tesarik Control of Maternal-to-Zygotic Transition in Human Embryos and Other Animal Species (Especially Mouse): Similarities and Differences International Journal of Molecular Sciences maternal-to-zygotic transition zygotic gene activation maternal mRNA decay M-decay Z-decay DNA transcription |
| title | Control of Maternal-to-Zygotic Transition in Human Embryos and Other Animal Species (Especially Mouse): Similarities and Differences |
| title_full | Control of Maternal-to-Zygotic Transition in Human Embryos and Other Animal Species (Especially Mouse): Similarities and Differences |
| title_fullStr | Control of Maternal-to-Zygotic Transition in Human Embryos and Other Animal Species (Especially Mouse): Similarities and Differences |
| title_full_unstemmed | Control of Maternal-to-Zygotic Transition in Human Embryos and Other Animal Species (Especially Mouse): Similarities and Differences |
| title_short | Control of Maternal-to-Zygotic Transition in Human Embryos and Other Animal Species (Especially Mouse): Similarities and Differences |
| title_sort | control of maternal to zygotic transition in human embryos and other animal species especially mouse similarities and differences |
| topic | maternal-to-zygotic transition zygotic gene activation maternal mRNA decay M-decay Z-decay DNA transcription |
| url | https://www.mdpi.com/1422-0067/23/15/8562 |
| work_keys_str_mv | AT jantesarik controlofmaternaltozygotictransitioninhumanembryosandotheranimalspeciesespeciallymousesimilaritiesanddifferences |