Evaluation of antiepileptic activity of the methanol extract of Trachyspermum ammi (L.)
This study aims to investigate the effect of a methanol extract of Trachyspermum ammi (L.) as an antiepileptic agent. Tests were conducted with a single- and multiple-dosing schedule of Trachyspermum ammi (L.), using a strychnine-induced seizure model for epilepsy. Twenty-one animals were divide...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2013-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641303815R.pdf |
| _version_ | 1818481544312913920 |
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| author | Rajput Muhammad Ali Khan Rafeeq A. Feroz Zeeshan |
| author_facet | Rajput Muhammad Ali Khan Rafeeq A. Feroz Zeeshan |
| author_sort | Rajput Muhammad Ali |
| collection | DOAJ |
| description | This study aims to investigate the effect of a methanol extract of Trachyspermum ammi (L.) as an antiepileptic agent. Tests were conducted with a single- and multiple-dosing schedule of Trachyspermum ammi (L.), using a strychnine-induced seizure model for epilepsy. Twenty-one animals were divided into three groups; control (vehicle), standard (diazepam) and test (Trachyspermum ammi (L.) extract). Trachyspermum ammi (L.) demonstrated antiepileptic effects, since there was a highly significant delay in the onset of convulsions as compared to the control, whereas the percentage of animals that survived or ignored seizure was also greater compared to the control. However, the duration of convulsions was significantly increased with both Trachyspermum ammi (L.) and diazepam as compared to the control. The methanol extract of Trachyspermum ammi (L.) showed antiepileptic activity, which may be due to the presence of thymol. |
| first_indexed | 2024-12-10T11:36:24Z |
| format | Article |
| id | doaj.art-233b485132b34c0fa79fad27fe83d680 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-12-10T11:36:24Z |
| publishDate | 2013-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-233b485132b34c0fa79fad27fe83d6802022-12-22T01:50:25ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392013-01-0165381581910.2298/ABS1303815REvaluation of antiepileptic activity of the methanol extract of Trachyspermum ammi (L.)Rajput Muhammad AliKhan Rafeeq A.Feroz ZeeshanThis study aims to investigate the effect of a methanol extract of Trachyspermum ammi (L.) as an antiepileptic agent. Tests were conducted with a single- and multiple-dosing schedule of Trachyspermum ammi (L.), using a strychnine-induced seizure model for epilepsy. Twenty-one animals were divided into three groups; control (vehicle), standard (diazepam) and test (Trachyspermum ammi (L.) extract). Trachyspermum ammi (L.) demonstrated antiepileptic effects, since there was a highly significant delay in the onset of convulsions as compared to the control, whereas the percentage of animals that survived or ignored seizure was also greater compared to the control. However, the duration of convulsions was significantly increased with both Trachyspermum ammi (L.) and diazepam as compared to the control. The methanol extract of Trachyspermum ammi (L.) showed antiepileptic activity, which may be due to the presence of thymol.http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641303815R.pdfTrachyspermum ammi (L.)strychninethymolbenzodiazepinesantiepileptic |
| spellingShingle | Rajput Muhammad Ali Khan Rafeeq A. Feroz Zeeshan Evaluation of antiepileptic activity of the methanol extract of Trachyspermum ammi (L.) Archives of Biological Sciences Trachyspermum ammi (L.) strychnine thymol benzodiazepines antiepileptic |
| title | Evaluation of antiepileptic activity of the methanol extract of Trachyspermum ammi (L.) |
| title_full | Evaluation of antiepileptic activity of the methanol extract of Trachyspermum ammi (L.) |
| title_fullStr | Evaluation of antiepileptic activity of the methanol extract of Trachyspermum ammi (L.) |
| title_full_unstemmed | Evaluation of antiepileptic activity of the methanol extract of Trachyspermum ammi (L.) |
| title_short | Evaluation of antiepileptic activity of the methanol extract of Trachyspermum ammi (L.) |
| title_sort | evaluation of antiepileptic activity of the methanol extract of trachyspermum ammi l |
| topic | Trachyspermum ammi (L.) strychnine thymol benzodiazepines antiepileptic |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641303815R.pdf |
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