Effects of short-chain per- and polyfluoroalkyl substances (PFAS) on human cytochrome P450 (CYP450) enzymes and human hepatocytes: An in vitro study

Effects of short-chain per- and polyfluoroalkyl substances (PFAS) on human cytochrome P450 (CYP450) enzymes and human hepatocytes: An in vitro study

Short-chain per- and polyfluoroalkyl substances (PFAS) have been developed as alternatives to legacy long-chain PFAS, but they may still pose risks due to their potential to interact with biomolecules. Cytochrome P450 (CYP450) enzymes are essential for xenobiotic metabolism, and disruptions of these...

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Bibliographic Details
Main Authors: Megan E. Solan, Ramon Lavado
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Current Research in Toxicology
Subjects:
Biotransformation
CYP450
CYP1A2
CYP3A4
PFAS
In vitro
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X23000142

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