A novel pyrrolidine-2,5-dione derivative induced G2/M phase arrest and apoptosis of hepatocellular carcinoma HepG2 cells through inhibiting tubulin polymerization

A novel pyrrolidine-2,5-dione derivative induced G2/M phase arrest and apoptosis of hepatocellular carcinoma HepG2 cells through inhibiting tubulin polymerization

Hepatocellular carcinoma (HCC) is a major global cause of carcinoma-related fatality. The inhibition of tubulin polymerization holds significant potential in the development of cancer drugs. In our study, we synthesized a novel pyrrolidine-2,5-dione derivative (compound 8) that exhibited potent anti...

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Bibliographic Details
Main Authors: Yingying Tian, Ailin Yang, Huiming Huang, Jinxin Xie, Longyan Wang, Dongxiao Liu, Xuejiao Wei, Peng Tan, Pengfei Tu, Dongjun Fu, Zhongdong Hu
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:Arabian Journal of Chemistry
Subjects:
Pyrrolidine-2,5-dione derivative
Hepatocellular carcinoma
Proliferation
G2/M phase arrest
Apoptosis
Tubulin polymerization
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535223010122

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